Prevalence of Hepatitis B Surface Antigen in Northern Nigerian
Blood Donors

Kulkarni, A.G.; Aloowooja, F.O.; Wayo, G.B.

doi:10.1159/000461414

Cited by 4 publications

(2 citation statements)

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“…The HBsAg sero‐prevalence rate of 6.08% in this study of pregnant women indicates intermediate endemicity of HBV infection in Lagos, Nigeria, and corroborates the sero‐prevalence level in blood donors, which has previously been reported to vary between 5.4 and 8.9% in various parts of Nigeria (10–12). This level of carrier state among pregnant women will suggest that there is a high risk of vertical transmission of HBV in Lagos.…”

Section: Discussionsupporting

confidence: 89%

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Rabiu

Akinola

Adewunmi

et al. 2010

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 89%

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Rabiu

Akinola

Adewunmi

et al. 2010

Acta Obstet Gynecol Scand

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“…Carrier rates may differ between tribes in a single country. For example, in Nigeria prevalences range from 2·9% in the Nupe to 21·4% in the Qwari [7]. Infection rates may also differ between villages: in Manduar in The Gambia 62% of children aged 2-4 years are infected, whereas in neighbouring Keneba only 27% are infected [8].…”

Section: Epidemiology Of Hbv Infection In Africamentioning

confidence: 99%

Epidemiology of HBV infection and HBV‐related hepatocellular carcinoma in Africa: natural history and clinical outcome

Kew

2006

ISBT Science Series

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Although data on the prevalence of chronic hepatitis B virus (HBV) infection and the incidence of hepatocellular carcinoma (HCC) in sub-Saharan Africa are incomplete, both conditions are undoubtedly common, and compelling evidence indicates that persistent HBV infection, acquired early in life, is the predominant risk factor for the tumour in the Bantu-speaking African peoples inhabiting the subcontinent.

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ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis

et al. 2020

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ObjectiveHepatitis B virus (HBV) infection is a major public health problem worldwide. Several studies have reported that ABO blood groups may be associated with HBV infection. However, its association is still controversial. We performed a meta-analysis to investigate whether ABO blood groups were associated with HBV infection.DesignSystematic review and meta-analysis.Data sourcesRelevant studies available before 1 December 2019 were identified by searching PubMed, EMBASE, Web of Science, ScienceDirect and the Cochrane Library.Eligibility criteriaAll cross-sectional or cohort studies from which the data of ABO blood group distribution and HBV infection could be extracted.Data extraction and synthesisStudies were identified and extracted by two reviewers independently. Risk ratios (RRs) and 95% CIs were pooled by random-effect models to quantify this association.ResultsThirty-eight eligible articles including 241 868 HBV-infected subjects and 6 487 481 uninfected subjects were included. Overall, the risk of HBV infection had decreased by 8% in subjects with blood group B when compared with non-B blood group (RR=0.92, 95% CI 0.86 to 0.98). In the subgroup analyses, the inverse relationship between blood group B and HBV infection remained stable in higher endemic areas (HBV prevalence ≥5%), Asian people, larger sample size studies (≥2000), general population and blood donors, lower middle income group and studies published before the year 2010. Additionally, subjects with blood group O had a 12% increased risk of HBV infection (RR=1.12, 95% CI 1.01 to 1.24) in higher endemic areas. In the sensitivity analysis, the pooled risk estimates of blood group B and HBV infection were still stable.ConclusionsOur data suggested that the blood group B was associated with a lower risk of HBV infection. More research is needed to clarify the precise role of the ABO blood group in HBV infection to address the global question of HBV infection.

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Prevalence of Hepatitis B Surface Antigen in Northern Nigerian Blood Donors

Abstract: 1,860 serum samples of blood donors from northern Nigeria were tested for the presence of the hepatitis B surface antigen. 8.9% of them were found to be positive. Significant differences in frequency were observed amongst various ethnic groups as well as ABO blood groups.

Cited by 4 publications

References 2 publications

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Epidemiology of HBV infection and HBV‐related hepatocellular carcinoma in Africa: natural history and clinical outcome

ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis

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