Prevalence of Hepatitis B Virus Infection and Associated Factors among HIV Positive Adults Attending ART Clinic at Hawassa Referral Hospital, SNNPR, Ethiopia

Belayneh, Fanuel

doi:10.4236/oalib.1101490

Cited by 12 publications

(25 citation statements)

References 19 publications

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“…A hospital based survey at South Gondar showed 6.1% HBsAg prevalence (Balew, 2014). The HBV/HIV coinfection rate in this study is high is consistent with a study done in sub Saharan Africa (Burnett, 2005), Shashemene (Negero et al, 2011) and at Hawassa (Belayneh, 2015). However, a study done at VCT centers in Addis Ababa showed no significant difference between HBsAg carriages per HIV status (Shimelis, 2008).…”

Section: Discussionsupporting

confidence: 89%

“…A previous history of surgical procedure showed significant association with HBV infection. This result is in line with the results of the studies conducted in Ethiopia at Hawassa (Belayneh, 2015). Individuals with history of multiple life time sexual partners were more likely to show HBsAg positive.…”

Section: Discussionsupporting

confidence: 89%

“…Considering the following assumptions: p = 7.7% (proportion of people infected by HBV) (Belayneh, 2015), Zα/2 is the value of the standard normal distribution corresponding to a significant level of alpha (α) of 0.05, which is 1.96 and desired degree of precision (d) of 3%, the computed sample size was 303 and by adding 10% nonresponse rate, the total sample size computed was 334. Participants were included in the study using systematic sampling technique.…”

Section: Study Design Setting and Participantsmentioning

confidence: 99%

“…The serum was also tested for HBsAg by one step according to the Guangzhou Wondfo Biotech Co., Ltd (Wondfo) instruction. This test has a sensitivity and specificity of 96.2 and 99.3%, respectively (Belayneh, 2015).…”

Section: Study Design Setting and Participantsmentioning

confidence: 99%

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Prevalence of hepatitis B virus, its risk factors and co-infection with human immune deficiency virus among clients of voluntary counseling and testing center in Hosanna, Southern Ethiopia

Asfaw¹,

Abebo²,

Kassahun³

2018

J. Public Health Epidemiol.

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Hepatitis B infection (HBV) infection is a serious public health problem worldwide and its co-infection with human immune deficiency virus (HIV) is common due to shared routes of transmission. An increased mortality due to accelerated hepatic disease progression and the frequent hepatotoxicity caused by antiretroviral therapy are the challenges in the clinical management of HIV. Epidemiological studies on HBV and HBV/HIV co infection are scarce in Ethiopia, particularly at the study area. The aim of this study was to determine the magnitude of HBV, its risk factors and co-infection with HIV among clients of a voluntary counseling and testing (VCT) center in Southern Ethiopia. A facility based crosssectional study was conducted from 1st February 2016 to 15th March among clients of Nigist Eleni Memorial Hospital VCT Center. Data were collected by face-to-face interview and specific formula sheet as well recorded results of laboratory diagnosis of blood sample from each participant. Both descriptive and inferential statistics were used for data analysis. Multivariable logistic regression modeling was done to identify predictors of HBV. Overall, 331 participants were included in the study. The prevalence of HBV was 8.8%, HBV/HIV co-infection was found in 3.6%. Individuals with a history of multiple sexual partner [AOR = 10.3; 95% CI, 3.71-28.83], previous history of invasive procedure [adjusted odds ratio (AOR) = 10.88; 95% CI, 3.84-30.86] and history of surgical procedure [AOR = 9.2; 95% CI, 3.1-27.88] were identified as in dependent predictors of HBV infection. High HBV infection and HBV/HIV co-infection was found in the study. Previous history of surgical procedure, invasive procedure and multiple sexual partners were identified as independent predictor of HBV infection.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Study Design Setting and Participantsmentioning

confidence: 99%

Section: Study Design Setting and Participantsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of hepatitis B virus, its risk factors and co-infection with human immune deficiency virus among clients of voluntary counseling and testing center in Hosanna, Southern Ethiopia

Asfaw¹,

Abebo²,

Kassahun³

2018

J. Public Health Epidemiol.

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“…The most recent study was conducted in 2019. Regarding the included studies on prevalence of HBV, more than of the half of the studies were obtained from Amhara region 22 (36.7%)[19, 28, 30, 35-37, 43, 45, 48, 49, 52, 57, 61, 62, 66-68, 70, 74, 77, 78, 81], Oromia region 12(20%)[31, 33, 40,46,47,55,59,60,63,82,84,86], and Southern Nations, Nationalities and Peoples Region (SNNPR) 9(15%)[29, 42,51,64,65,69,73,75,85]…”

mentioning

confidence: 99%

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Yazie

Girma

2019

Preprint

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Background Hepatitis B virus is one of the major public health concerns globally. It is highly infectious and can be transmitted from one person to the other through vertically or horizontally via contaminated body fluid exposure. Despite the provision of an effective vaccine, it remains a major problem worldwide, particularly in developing countries. Methods Online electronic databases including PubMed, Google Scholar, Science Direct, African Index Medicus, African Journals Online, and WHO Afro Library were searched and published articles from 2010 to June 8, 2019, were considered. Two authors independently screened articles and extracted data. Funnel-Plots and Egger’s test statistics were used to determine the presence of small study effects and publication bias. The pooled prevalence of HBV was analyzed using a random effects model. The possible sources of heterogeneity was analyzed through subgroup analysis, sensitivity analysis, and meta-regression. Results The overall pooled prevalence of HBV was 6% and among subgroups pregnant women, healthcare workers, and HIV positive patients accounted for 5% for each group. Relatively low prevalence (4%) was obtained among blood donors. The Egger’s test statistics (p=0.747) indicated the absence of publication bias. In addition, from the sensitivity analysis, there was no influence on the overall effect while removing a single study at a time. The level of heterogeneity was reduced among pregnant women, HIV positive and studies with unknown sampling techniques. After conducting meta-regression, province, study group, screening method, and quality of papers were identified as sources of heterogeneity. Conclusions The overall pooled prevalence of HBV in Ethiopia was high. Strengthening and scaling up of the scope of the existing vaccination program and implementing novel approaches including screen-and-treat could be implemented to reduce the burden of the disease. Generally, the study can provide current prevalence estimate of HBV that could vital for intervention to tackle the disease.

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Hepatitis viruses in Ethiopia: a systematic review and meta-analysis

et al. 2016

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BackgroundThe existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic review and meta-analysis was to provide a clear and comprehensive estimation of viral hepatitis epidemiology and the potential clinical burdens in Ethiopia.MethodsA comprehensive literature search was carried out from five decades (1968–2015) published studies from biomedical databases; PubMed, Google scholar, Medline and Web of Science.ResultsThe overall pooled prevalence of hepatitis B virus (HBV) was 7.4% (95%CI: 6.5–8.4). The pooled prevalence among subgroups showed 5.2% (95%CI: 3.7–7.4) in human immunodeficiency virus (HIV) infected individuals, 8.0% (95%CI: 5.9–10.7) in community based studies, 8.4% (95%CI: 5.4–12.7) in blood donors, 11.0% (95%CI: 7.5–15.9) in immigrants and 6.9% (95%CI: 5.6–8.5) in other groups. Among study parameters considered during meta-regression analysis, only study years were associated with a decreasing HBV prevalence rate over time. The overall pooled prevalence of anti-hepatitis C virus antibody (anti-HCV) was 3.1% (95%CI: 2.2–4.4). Unlike HBV, the anti-HCV prevalence in HIV infected individuals was higher (5.5%, 95%CI: 3.8–7.8%, p = 0.01) than the prevalence observed in the other subgroup of study population. Although relatively few data were available, hepatitis virus A (HAV), D (HDV) and E (HEV) were also circulated in Ethiopia.ConclusionsThis review indicates that all types of viral hepatitis origins are endemic in Ethiopia. Adapting a recommended diagnostic and treatment algorithm of viral hepatitis in the routine healthcare systems and implementing prevention and control policies in the general population needs an urgent attention.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2090-1) contains supplementary material, which is available to authorized users.

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Prevalence of Hepatitis B Virus Infection and Associated Factors among HIV Positive Adults Attending ART Clinic at Hawassa Referral Hospital, SNNPR, Ethiopia

Cited by 12 publications

References 19 publications

Prevalence of hepatitis B virus, its risk factors and co-infection with human immune deficiency virus among clients of voluntary counseling and testing center in Hosanna, Southern Ethiopia

Prevalence of hepatitis B virus, its risk factors and co-infection with human immune deficiency virus among clients of voluntary counseling and testing center in Hosanna, Southern Ethiopia

An updated systematic review and meta-analysis of the prevalence of hepatitis B virus in Ethiopia

Hepatitis viruses in Ethiopia: a systematic review and meta-analysis

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