Prevalence of hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma in Korea

Park, B. C.; Han, Byung Hoon; Ahn, Sungjin; Lee, S. W.; Lee, D. H.; Lee, Y. N.; Sec, J. H.; Kim, K. W.

doi:10.1111/j.1365-2893.1995.tb00029.x

Cited by 12 publications

(13 citation statements)

References 32 publications

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“…HCV/HDV coinfection may also suppress HBV replication and thus lead to the "anti-HBc alone" serostatus [Liaw et al, 1991b;Fong et al, 1991;Fattovich et al, 1991;Liaw et al, 1992;Sheen et al, 1992;Shih et al, 1993;Francisci et al, 1995;Park et al, 1995;Jilg et al, 1995;Jylberberg and Pol, 1996;Hofer et al, 1998;Opravil et al, 1998]. This assumption is consistent with the frequent coincidence of anti-HBc and HCV markers and is supported by in vitro experiments [Shih et al, 1993].…”

Section: Chronic Infectionsupporting

confidence: 70%

Serological pattern ?anti-HBc alone?: Report on a workshop

et al. 2000

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In areas with low hepatitis B virus (HBV) endemicity such as most parts of Europe and the United States "anti-HBc alone" is found in 10-20% of all individuals with HBV markers, i.e., 1-4% of the population. In about 10% of these individuals HBV DNA is detected by PCR, the proportions varying greatly depending on the population studied, being highest in individuals coinfected with hepatitis C virus (HCV) (above 35%) and HIV (above 85%). A small proportion of individuals with "anti-HBc alone" are in the window phase of an HBV infection or in a stage of late HBV immunity. For the large proportion of these individuals this is not the case and they are thought to have an unresolved HBV-infection or a chronic infection in a late or "low grade" productive state. Currently, limited studies have been performed concerning the clinical aspects of individuals with "anti-HBc alone" and suspected chronic HBV infection. The majority of these individuals seem to be healthy. Some chronic carriers with "anti-HBc alone," however, do present signs of chronic hepatitis. Individuals with "anti-HBc alone" are potentially infectious. This is exemplified by a few case reports of HBV transmission to sexual contacts, perinatal transmission between mother and newborns and in blood recipients. Recommendations are given in relation to both the diagnostic and therapeutic procedures in the individuals with "anti-HBc alone" and in the blood banking and transplantation services.

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Section: Chronic Infectionsupporting

confidence: 70%

Serological pattern ?anti-HBc alone?: Report on a workshop

et al. 2000

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“…No differences were found in summary OR according to type of controls. The crude OR for HBsAg and for anti-HCV-HCV RNA were lower than the adjusted ones in 6 of the 7 studies with secondgeneration anti-HCV/HCV RNA tests that reported OR adjusted for each marker and for demographic variables (Chang et al, 1994;Donato et al, 1997;Hadziyannis et al, 1995;Park et al, 1995;Stroffolini et al, 1992;Sun et al, 1996;.…”

Section: Resultsmentioning

confidence: 94%

“…A total of 32 case-control studies (Bile et al, 1993;Bruix et al, 1989;Cenac et al, 1995;Chang et al, 1994;Chuang et al, 1992;Cordier et al, 1993;Coursaget et al, 1992;Dazza et al, 1993;Di Bisceglie et al, 1991;Donato et al, 1997;Fukuda et al, 1993;Hadziyannis et al, 1995;Kaczynski et al, 1996;Kaklamani et al, 1991;Kew et al, 1997;Nomura et al, 1996;Okuno et al, 1994;Park et al, 1995;Pyong et al, 1994;Saito et al, 1990;Shin et al, 1996;Simonetti et al, 1992;Stroffolini et al, 1992;Sun et al, 1996;Tsai et al, 1996a;Xu et al, 1990;Yang et al, 1996;Yu, M.C. et al, 1997;Yu et al, 1991;Yu, S.-Z.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma

1998

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The aim of the study was to assess whether co‐infection by hepatitis‐B virus (HBV) and hepatitis‐C virus (HCV) is associated with a higher risk of developing hepatocellular carcinoma (HCC) than each infection alone. A meta‐analysis of data published up to June 1997 was performed. HBsAg and anti‐HCV antibodies or HCV RNA (anti‐HCV/HCV RNA) were considered as serological markers of current HBV and HCV infection respectively. A total of 32 case‐control studies were suitable for a quantitative overview. The summary odds ratios (OR) were 13.7 for HBsAg positivity and 11.5 for anti‐HCV/HCV RNA positivity. The OR for anti‐HCV was lower among studies using second‐ or third‐generation anti‐HCV or HCV RNA (OR, 8.2) with respect to studies with first‐generation anti‐HCV test (OR, 19.1). When combining data from the studies with second‐ or third‐generation anti‐HCV or HCV RNA, the OR for HBsAg positivity and anti‐HCV/HCV RNA negativity was 22.5 (95% confidence interval (CI), 19.5–26.0), the OR for anti‐HCV/HCV RNA positivity and HBsAg negativity was 17.3 (95% CI, 13.9–21.6), and the OR for both markers positivity was 165 (95% CI: 81.2–374, based on 191 cases and 8 controls exposed). A synergism was found between HBV and HCV infections, the OR for co‐infection being greater than the sum and lower than the product of those for each infection alone. The interaction was therefore negative according to the multiplicative model, providing epidemiological evidence both of an independent effect and of interference between the 2 viruses in the carcinogenic process. Int. J. Cancer 75:347–354, 1998. © 1998 Wiley‐Liss, Inc.

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“…In Korea, the prevalence of HCV infection ranges from 1.3% to 1.6% and the virus is the agent secondarily responsible following HBV for chronic liver diseases (19, 20). This study is the first report to demonstrate an association between HLA and the susceptibility to HCV infection in the Korean population, who have a single ethnic background.…”

Section: Discussionmentioning

confidence: 99%