Prevalence of Hepatitis C–Related Cirrhosis in Elderly Asian Patients Infected in Childhood

D’Souza, Raymond; Glynn, Michael; Ushiro-Lumb, Inês; Feakins, Roger; Domizio, P.; Mears, L; Alsced, Elspeath; Kumar, Parvar; Sabin, Caroline; Foster, Graham R.

doi:10.1016/s1542-3565(05)00527-6

Cited by 37 publications

(33 citation statements)

References 15 publications

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“…Without taking other variables into account, this was different across races, particularly when histology alone was examined. In accordance with published literature [2][3][4][5], we found the prevalence of histological cirrhosis to be greatest in Hispanics (40%), compared to Caucasians (19%), AA (17%), and As (13%; Table 2). However, some of these differences were less significant.…”

Section: Discussionsupporting

confidence: 91%

“…Based on these estimated measures, fibrosis progression appears to be in part determined by race/ethnicity [2][3][4][5]. In particular, Hispanics have been found to have more significant histological liver disease [2,5], while African Americans have shown lower levels of fibrosis compared to Caucasians [3].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, Hispanics have been found to have more significant histological liver disease [2,5], while African Americans have shown lower levels of fibrosis compared to Caucasians [3]. In the UK, cirrhosis was found to be more common in Asian patients; however, the majority of these patients were from the Indian subcontinent [4]. Little is known of the frequency of histological and clinical cirrhosis in Asians patients with CHC in the US.…”

Section: Introductionmentioning

confidence: 99%

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Histological Versus Clinical Cirrhosis in Chronic Hepatitis C: Does Race/Ethnicity Really Matter?

Kohla

Iwata

et al. 2011

Dig Dis Sci

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological Versus Clinical Cirrhosis in Chronic Hepatitis C: Does Race/Ethnicity Really Matter?

Kohla

Iwata

et al. 2011

Dig Dis Sci

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“…Studies in a cohort infected during plasma donation over 35 years ago and hospital-based cohorts infected for many decades indicate that the incidence of cirrhosis and decompensation or death may increase with age (Fig 1). 8,9 The reassurance from early cohort studies indicating that severe liver disease was probable only in a minority of HCVinfected patients has been replaced by concerns that, with prolonged infection, the proportion developing severe liver disease will increase. The outcome of chronic HBV infection is complex (Fig 2) -most patients are infected in early childhood and initial infection leads to inactive HBeAgpositive disease with high-level viraemia and minimal liver damage.…”

Section: Epidemiology Of Chronic Viral Hepatitismentioning

confidence: 99%

Recent advances in viral hepatitis

Foster

2009

Clinical Medicine

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“…In addition, the basic factors in the progression of chronic HCV include the Asian race, co-infection with HBV and HIV, age over 40 years, male sex, and alcohol abuse [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of liver fibrosis in patients with HIV/chronic hepatitis C co-infection in different ethnic groups

Sarsekeyeva

Кошерова

Azizov

2016

J Infect Dev Ctries

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Introduction: In recent years, the frequency of human immunodeficiency virus (HIV) and hepatitis C (HCV) co-infection has increased, which is due to their common routes of transmission. HIV/chronic HCV co-infection aggravates the development of fibrosis and increases the risk of cirrhosis. The aim of the study was to evaluate the results of liver elastometry in patients of different ethnic groups with HIV/chronic HCV co-infection. Methodology: The study involved 49 Kazakh and 46 Russian patients with HIV/chronic HCV co-infection. The stage of liver fibrosis was assessed by the results of indirect ultrasonic liver elastometry according to the METAVIR scale using FibroScan 502. As an indirect marker of liver fibrosis, level of alanine aminotransferase and aspartate aminotransferase, as well as platelet counts, were determined. Results: Analysis of the results with the evaluation of the dynamics of fibrotic process in 36 months revealed a prevalence of patients with advanced liver fibrosis (F3, F4) among Kazakh compared with Russian patients, accompanied by a significant increase of liver elasticity indices in Kazakhs and Russians (p < 0.05). Significant differences in the indices of transaminases in the patients with later stages of liver fibrosis (F3, F4) were found (p < 0.05). Conclusions: The study of patients with HIV/chronic HCV co-infection revealed differences in the progression of liver fibrosis depending on ethnicity. Results of elastometry and indirect markers of liver fibrosis were used in the comprehensive assessment at different stages of liver fibrosis.

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Prevalence of Hepatitis C–Related Cirrhosis in Elderly Asian Patients Infected in Childhood

Cited by 37 publications

References 15 publications

Histological Versus Clinical Cirrhosis in Chronic Hepatitis C: Does Race/Ethnicity Really Matter?

Histological Versus Clinical Cirrhosis in Chronic Hepatitis C: Does Race/Ethnicity Really Matter?

Recent advances in viral hepatitis

Comparative assessment of liver fibrosis in patients with HIV/chronic hepatitis C co-infection in different ethnic groups

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