Prevalence of hepatitis C virus infection among health-care workers: A 10-year survey

Marconi, Andrea; Candido, Saverio; Talamini, Renato; Libra, Massimo; Nicoletti, Ferdinando; Spandidos, Demetrios Α.; Stivala, Franca; Proietti, Lidia

doi:10.3892/mmr_00000297

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Intriguingly, a case of gastric Malt lymphoma was observed among those with HCV infection (21). As revealed in the previous independent survey of HCWs by Marconi et al , 2010, the molecular analyses performed in such Malt tumor tissue supported the notion that HCV infection was associated with the malignant transformation (20). …”

Section: Hcv Infection As a Risk Factor For Lymphoma Developmentsupporting

confidence: 60%

“…An important result of the study was that in the 10-year survey there were no new infections by HCV in the monitored workers. This result stresses the concept that the correct handling procedures of hazardous biological materials and the use of personal protective equipment lead to a reduction or a total avoidance of the risk of infection due to biohazard materials (20,34). Therefore, these data are in agreement with previous studies demonstrating that the education of workers employed in hospitals or laboratories on the prevention of needle-stick accidents or sharp injuries is able to decrease needle-stick injuries (35–37).…”

Section: Hcv Infection In Health-care Workersmentioning

confidence: 69%

“…In our experience, the above mentioned 10-year study, revealed that one of the HCV-infected HCWs, with a chronic infection history of 25 years, developed a mucosa-associated lymphoid tissue lymphoma (MALT) of the liver (20). Molecular analyses of tumor tissue indicated that immunoglobulin gene combinations were those usually detected among HCV-associated lymphomas (11).…”

Section: Hcv Infection As a Risk Factor For Lymphoma Developmentmentioning

confidence: 97%

“…Our previous studies described the frequency of HCV infection among HCWs and a case of non-Hodgkin lymphoma was diagnosed during the survey (20,21). According to this observation, in the present review, HCV infection among HCWs is analyzed taking into account the association with lymphoma development.…”

Section: Introductionmentioning

confidence: 99%

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The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

Garozzo

Falzone

Rapisarda

et al. 2017

Molecular Medicine Reports

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Health care workers (HCWs) are frequently exposed to different biological agents during their activities and are frequently monitored. Among these infectious agents, human hepatitis C (HCV) can infect HCWs. In this review article, the risk of HCV infection among HCWs is discussed along with extrahepatic HCV-related malignancies, such as non-Hodgkin lymphoma. Accidental contamination, represented by percutaneous and mucocutaneous infections is the main risk factor for such infection. The compliance of the protection procedures, included in the current regulation for HCWs, is the most important issue to reduce the risk of pathogen infections that in turn may produce reduction of infection-associated malignancies.

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Section: Hcv Infection As a Risk Factor For Lymphoma Developmentsupporting

confidence: 60%

Section: Hcv Infection In Health-care Workersmentioning

confidence: 69%

Section: Hcv Infection As a Risk Factor For Lymphoma Developmentmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

Garozzo

Falzone

Rapisarda

et al. 2017

Molecular Medicine Reports

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“…Studies have demonstrated that NAFLD is an important risk factor for the development of primary liver cancer, mostly due to NAFLD-associated cirrhosis (cryptogenic cirrhosis) (9,10). A high prevalence of NAFLDS occurs in hepatitis C virus infections where double antiviral therapy with peginterferon and ribavirin can have a significant impact on the progression of the disease (11,12). Understanding the pathogenesis, biochemical parameters, histological grading and staging, and the management of NAFLD, are vital in clinical practice today.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline

Cioboată

Găman

Traşcă

et al. 2017

Experimental and Therapeutic Medicine

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In this study, we aimed to evaluate the efficacy of pentoxifylline and atorvastatin in the treatment of non-alcoholic fatty liver disease (NAFLD). The study included 98 patients with histologically confirmed NAFLD divided into 2 groups as follows: group I (57 dyslipidemic patients, receiving atorvastatin 20 mg/day and group II (41 non-dyslipidemic patients, treated with pentoxifylline, 800 mg/day). The present study was conducted for a mean of 32.8±3.4 weeks. For all patients, we determined the body mass index, a liver biopsy was performed, and we measured the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), total cholesterol (TC) and triglycerides (TG) at the beginning and at the end of the study period. The NAFLD activity score (NAS) was used to evaluate the liver biopsies for steatosis, fibrosis and necroinflammation. The patients in group I exhibited a considerable reduction in ALT, AST, GGT, TC, AP and TG levels (P<0.0001). Histologically, there were no changes in fibrosis and necroinflammation, although the extent steatosis was reduced. The improvement in the ALT, AST and GGT values (P<0.05) in group II were similar to those in group I; however, no statistically significant decrease was noted in the levels of ALP, TC and TG in this group. Our results thus demonstrated that atorvastatin attenuated steatosis and improved liver function parameters in patients with NAFLD associated with dyslipidemia. Similar results were obtained in the non-dyslipidemic patients administered pentoxifylline.

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Hepatitis C virus infection among transmission-prone medical personnel

Zaaijer

Appelman

Frijstein

2011

Eur J Clin Microbiol Infect Dis

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Hepatitis C virus (HCV)-infected physicians have been reported to infect some of their patients during exposure-prone procedures (EPPs). There is no European consensus on the policy for the prevention of this transmission. To help define an appropriate preventive policy, we determined the prevalence of HCV infection among EPP-performing medical personnel in the Academic Medical Center in Amsterdam, the Netherlands. The prevalence of HCV infection was studied among 729 EPP-performing health care workers. Serum samples, stored after post-hepatitis B virus (HBV) vaccination testing in the years 2000–2009, were tested for HCV antibodies. Repeat reactive samples were confirmed by immunoblot assay and the detection of HCV RNA. The average age of the 729 health care workers was 39 years (range 18–66), suggesting a considerable cumulative occupational exposure to the blood. Nevertheless, only one of the 729 workers (0.14%; 95% confidence interval [CI]: <0.01% to 0.85%) was tested and confirmed to be positive for anti-HCV and positive for HCV RNA, which is comparable to the prevalence of HCV among Amsterdam citizens. Against this background, for the protection of personnel and patients, careful follow-up after needlestick injuries may be sufficient. If a zero-risk approach is desirable and costs are less relevant, the recurrent screening of EPP-performing personnel for HCV is superior to the follow-up of reported occupational exposures.

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Prevalence of hepatitis C virus infection among health-care workers: A 10-year survey

Cited by 8 publications

References 14 publications

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

The risk of HCV infection among health-care workers and its association with extrahepatic manifestations

Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline

Hepatitis C virus infection among transmission-prone medical personnel

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