Prevalence of Hepatitis C Virus Antibody in Beta-Thalassemic Polytransfused Children in a Long-Term Follow-Up

Resti, M.; Azzari, C.; Rossi, M.E.; Vullo, C.; Borgatti, L.; Vierucci, A.

doi:10.1159/000461298

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…In the same group of patients we observed a very high prevalence of positivity for anti-HCV antibodies, higher than that previously reported by other Italian authors (Resti et al, 1991;Cacopardo et al, 1992;Rebulla et al, 1992;Lai et al, 1993). This is probably due to the longer exposure to HCV of our adult patients, since seroconversion was strongly correlated with transfusional age before the availability of HCV diagnostic tests (Borzini et al, 1991).…”

Section: Discussionsupporting

confidence: 58%

“…In recent years, following the identification of hepatitis C virus (HCV) and the introduction of diagnostic tests which detected antibodies against HCV , this virus was recognized as the major cause of post-transfusion hepatitis (Alter, 1990;Miyamura et al, 1990). Very high prevalences of HCV markers, usually exceeding 60%, have been described by several authors (Resti et al, 1991;Cacopardo et al, 1992;Rebulla et al, 1992;Lai et al, 1993) in Italian thalassaemia patients.…”

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confidence: 99%

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Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

et al. 1997

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Summary. The risk of polytransfused patients for hepatitis C virus (HCV) infection is likely to extend to another recently identified member of the Flaviviridae, hepatitis G virus (HGV). We investigated the prevalence of HGV in 40 adult Italian patients with transfusion-dependent thalassaemia and evaluated the clinical significance of HGV infection. HGV-RNA was detected in 9/40 patients (22·5%). HGV infection was significantly associated with HCV viraemia (P ¼ 0·0012), with all patients positive for HGV being also viraemic for HCV. Overall, the clinical picture of patients with HCV/HGV co-infection was not different from that of patients with isolated HCV. However, patients co-infected with both viruses had lower values of alanine-transferase (P ¼ 0·035) and a lower titre of HCV viraemia (P ¼ 0·042) in the absence of other evident factors which could influence the clinical expression of HCV infection. In conclusion, HGV is highly prevalent among Italian polytransfused patients. No evidence of a clinically significant pathogenic role for HGV in liver disease could be found in these patients. In a subset of cases a possible interference of HGV with HCV infection was observed.

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Section: Discussionsupporting

confidence: 58%

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confidence: 99%

Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

et al. 1997

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“…The prevalence of anti-HCV in many populations at risk such as haemophiliacs [10,19], leukaemia patients [18], and drug abusers [10] is very high. Beta-thalassaemic children who are routinely treated with blood transfusion are a population at risk for HCV infection [23] and the risk for developing an acute or chronic hepatitis is very high.…”

Section: Offprint Requests To: a Vieruccimentioning

confidence: 99%

Hepatitis C virus antibodies in a long-term follow-up of beta-thalassaemic children with acute and chronic non-A non-B hepatitis

et al. 1992

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The presence of antibodies toward hepatitis C virus (HCV) was examined in 78 polytransfused beta-thalassaemic children. The anti-HCV status was correlated with acute and chronic non-A non-B (NANB) hepatitis that developed during a follow up of about 13 years. Anti-HCV was present in 83.3% of children with acute NANB hepatitis and in 82.9% of those with chronic NANB hepatitis. The percentage of chronic evolution was 56.7% for acute anti-HCV positive NANB hepatitis and 50.0% for anti-HCV negative NANB hepatitis. The long-term persistence of anti-HCV antibodies did not correlate with chronic evolution of liver infection in thalassaemic patients. Histological features of chronic hepatitis showed little or no difference between HCV associated or non-associated liver disease. The multifactorial liver injury in beta-thalassaemic children explains the high prevalence of cirrhosis (about 30%) observed in these patients with NANB hepatitis. On the other hand, independent of liver disease, some patients never seroconverted during the follow up in spite of the high number of transfusions suggesting the existence of "non-responders".

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“…The cloning of an NANB hepatitis agent, HCV, and the development of an assay to detect antibodies against its major gene products has enabled the precise incidence of transfusion-transmitted hepatitis C to be evaluated. First-generation tests gave a high incidence of anti-HCV antibodies in polytransfused patients: those re ceiving chronic RBC transfusions had a reported inci dence of 63 [30], 55 [31], 40 [32] (thalassemia patients), 20 [33] and 38% [34] (hemodialyzed patients). The detection of anti-HCV was more accurate with the introduction of a more sensitive and specific second-generation test and a higher incidence of anti-HCV was reported in the same…”

Section: Discussionmentioning

confidence: 99%

Frozen Blood and Transfusion-Transmitted Hepatitis C Virus

Norol¹,

Bachir²,

Bernaudin³

et al. 1993

Vox Sanguinis

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The purpose of the present study was to evaluate the impact of frozen red cell transfusion on the transmission of hepatitis C virus (HCV) before the introduction of blood donor screening. Anti-HCV antibodies were detected in 59 patients with sickle-cell disease who required chronic transfusions and had exclusively received frozen red blood cells (RBC). The files were reviewed for clinical signs of chronic hepatitis C. Anti-HCV antibodies were detected in 2 adult patients; both also had clinical evidence of HCV infection. No other patient showed signs of acute or chronic HCV hepatitis. In a control group of 28 patients who had received nonfrozen RBC transfusions, the prevalence of anti-HCV antibodies was 25%. So, our study seems to indicate that the use of frozen RBC had reduced the risk of HCV contamination.

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Prevalence of Hepatitis C Virus Antibody in Beta-Thalassemic Polytransfused Children in a Long-Term Follow-Up

Cited by 9 publications

References 7 publications

Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

Hepatitis C virus antibodies in a long-term follow-up of beta-thalassaemic children with acute and chronic non-A non-B hepatitis

Frozen Blood and Transfusion-Transmitted Hepatitis C Virus

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