Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

Sadeghi, Farzin; Salehi‐Vaziri, Mostafa; Almasi‐Hashiani, Amir; Gholami-Fesharaki, Mohammad; Pakzad, Reza; Alavian, Seyed Moayed

doi:10.5812/hepatmon.35558

Cited by 31 publications

(26 citation statements)

References 102 publications

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“…Several recent studies have provided good evidence on genotype distribution and epidemiology of HCV in the Middle East region (57)(58)(59). However, determination of HCV seroprevalence rates among blood donors in the Middle East region could be helpful to develop prevention and control strategies more effectively.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Ghaderi-Zefrehi

Sharafi

Sadeghi

et al. 2017

Iran Red Crescent Med J

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Context: Hepatitis C virus (HCV) has been the main cause of post transfusion hepatitis. Long-term hepatitis can ultimately result in cirrhosis and hepatocellular carcinoma. Viral hepatitis, especially HCV infection, is a major health concern in the Middle East. The current study carried out a systematic search concerning HCV seroprevalence among blood donors in Middle Eastern countries. Evidence Acquisition: Articles were identified through searching databases including PubMed, Scopus, and Web of Science. We reviewed systematically all studies reporting HCV seroprevalence among blood donors in Middle Eastern countries. Results: A total of 5662 relevant records were identified by the electronic search, of which a total of 47 studies were identified as eligible papers that were meta-analyzed for the pooled seroprevalence of HCV among blood donors. Overall, HCV seroprevalence among blood donors in Middle Eastern countries was estimated 0.88% (95%CI = 0.79% -0.97%). The highest pooled HCV seroprevalence rate was related to Egypt (5.76% [95%CI = 3.30% -8.22%]), Libya (1.56% [95%CI = 0.99% -2.13%]), and Yemen (1.09% [95%CI = 0.69% -1.50%]) while the lowest pooled seroprevalence rate was in Iran and Israel with the rates of 0.14% (95%CI = 0.12% -0.17%) and 0.16% (95%CI = 0.06% -0.25%), respectively. Results of annual HCV seroprevalence suggest that there is a decrease in seroprevalence rate of HCV over time among blood donors in Egypt, Iran, Oman, Lebanon, Libya, and Saudi Arabia. Conclusions: Our results showed that the trend of HCV seroprevalence over time among Middle Eastern blood donors was decreasing. It suggests that recent safety measures implemented in Middle Eastern countries have been effective.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Ghaderi-Zefrehi

Sharafi

Sadeghi

et al. 2017

Iran Red Crescent Med J

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“…As previously described, genotype distribution does not show high variability among the three macro‐areas: genotype 1 (G1) seems to be equally distributed among them (70.0% in Central Europe, 68.1% in Eastern Europe, and 55.1% in Western Europe), like genotype 3 (G3) (29.0% in Western Europe, 26.6% in Eastern Europe, and 21.0% in Central Europe). Genotype 2 (G2), instead, seems to be most common in Western Europe (8.9%), while genotype 4 (G4) is essentially present in Central and Western Europe (4.9% and 5.8%, respectively) …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review

Petruzziello

Loquercio

Sabatino

et al. 2019

Clinical Laboratory Analysis

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BackgroundHepatitis C virus (HCV) infection is a global health problem especially for its increasing level of mortality. Detailed knowledge of HCV genotypes prevalence has clinical relevance since the efficacy of therapies is impacted by genotypes and subtypes distribution. Moreover, HCV exhibits a great genetic variability regionally.To date, there are no published studies assessing HCV genotypes distribution in specific countries of the Mediterranean basin. The aim of this study was to review data published from 2000 to 2017 with the purpose to estimate genotypes distribution of HCV infection in nine European countries all located in the Mediterranean basin.MethodsA systematic research of peer‐reviewed journals indexed in PubMed, Scopus, and EMBASE databases selected if containing data regarding distribution of HCV genotypes in nine selected European countries (Albania, Bosnia, Croatia, France, Greece, Italy, Montenegro, Slovenia, and Spain) was performed.ResultsGenotype 1 is the most common (61.0%), ranging from 80.0% in Croatia to 46.0% in Greece, followed by genotype 3 (20.0%), varying from 38.0% in Slovenia to 7.0% and 8.0%, respectively, in Italy and in Albania and by genotype 4 (10.0%) that shows an increase of 1.1% with respect to data obtained till 2014 probably due to the increasing migrants arrivals to Southern Europe. G2, the fourth most frequent genotype (8.5%), particularly common in Italy (27.0%) and Albania (18.0%) might be probably introduced in Southern Italy as a result of Albanian campaign during Second World War and more and more increased by the migration flows from Albania to Italy in the 90s.ConclusionEpidemiology of HCV infection shows a high variability across the European countries that border the Mediterranean Sea. HCV genotyping is a relevant tool to monitor the dynamic process influenced by both evolving transmission trends and new migration flows on HCV scenario.

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“…The distribution of HCV genotypes and subtypes in Iran and other Middle Eastern and EMRO countries has a very diverse pattern. Altogether, the HCV-1 (-1a and -1b) is the predominant genotype in Iran, so that more than half of the HCV-infected patients in Iran are infected with this genotype (with a rate of 54%) (12, 18). …”

Section: Discussionmentioning

confidence: 99%

“…Up to now, HCV is classified into seven different genotypes and more than 67 subtypes according to the genetic variability and viral sequences (11). The linkage of geographic distribution of HCV genotypes in different populations and specific risk groups to genetic diversity of HCV is obvious (12). Genotype of HCV is a considerable factor with clinical and epidemiological importance because it determines the rate of response to the HCV therapy, and may help trace the source of infection and clarify the possible modes of transmission (13).…”

Section: Contextmentioning

confidence: 99%

Molecular Tracing of Hepatitis C Virus Genotype 1 Isolates in Iran: A NS5B Phylogenetic Analysis with Systematic Review

et al. 2016

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ContextHepatitis C virus (HCV) is characterized by a high degree of genetic heterogeneity and classified into 7 genotypes and different subtypes. It heterogeneously distributed through various risk groups and geographical regions. A well-established phylogenetic relationship can simplify the tracing of HCV hierarchical strata into geographical regions. The current study aimed to find genetic phylogeny of subtypes 1a and 1b of HCV isolates based on NS5B nucleotide sequences in Iran and other members of Eastern Mediterranean regional office of world health organization, as well as other Middle Eastern countries, with a systematic review of available published and unpublished studies.Evidence AcquisitionThe phylogenetic analyses were performed based on the nucleotide sequences of NS5B gene of HCV genotype 1 (HCV-1), which were registered in the GenBank database. The literature review was performed in two steps: 1) searching studies evaluating the NS5B sequences of HCV-1, on PubMed, Scopus, and Web of Science, and 2) Searching sequences of unpublished studies registered in the GenBank database.ResultsIn this study, 442 sequences from HCV-1a and 232 from HCV-1b underwent phylogenetic analysis. Phylogenetic analysis of all sequences revealed different clusters in the phylogenetic trees. The results showed that the proportion of HCV-1a and -1b isolates from Iranian patients probably originated from domestic sources. Moreover, the HCV-1b isolates from Iranian patients may have similarities with the European ones.ConclusionsIn this study, phylogenetic reconstruction of HCV-1 sequences clearly indicated for molecular tracing and ancestral relationships of the HCV genotypes in Iran, and showed the likelihood of domestic origin for HCV-1a and various origin for HCV-1b.

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Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

Cited by 31 publications

References 102 publications

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Prevalence of Hepatitis C virus genotypes in nine selected European countries: A systematic review

Molecular Tracing of Hepatitis C Virus Genotype 1 Isolates in Iran: A NS5B Phylogenetic Analysis with Systematic Review

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