CO comes from incomplete combustion. CO can bind with hemoglobin 245 times faster than with oxygen. Workshop workers are one of the jobs that are at risk of being exposed to carbon monoxide every day. This systematic study aims to describe the factors associated with COHB levels in workshop workers. The research was conducted online using a systematic review by accessing journal databases such as Google Scholar, Portal Garuda, PubMed, Scopus, Proquest, ScienceDirect 2010-2020. It was screened by inclusion criteria (publication period, full-test access, observational research, independent and dependent variables) and exclusion criteria; seven articles matched the criteria. The results showed that the CO in the air could affect the COHb levels of workers. Especially the workers, as mechanics, have unacceptable levels of COHb. The duration of exposure and working period can increase the risk factors of COHb levels.