Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women aged 18–25 in Jiangsu Province

Hu, Shangying; Hong, Ying; Zhao, Fanghui; Lewkowitz, Adam K.; Chen, Feng; Zhang, Wenhua; Pan, Qin-Jing; Zhang, Xun; Fei, Cindy; Li, Hui; Qiao, You‐Lin

doi:10.1007/s11670-011-0025-3

Cited by 26 publications

(27 citation statements)

References 23 publications

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“…The official minimum age for marriage for women is 20 years in China, but social norms are changing and a substantial proportion of women commences sexual activity before this age. We did not evaluate risk factors for HPV infection, but in a previous epidemiological study conducted in Jiangsu Province, the number of lifetime sexual partners, husbands' ex‐marital sexual relationships and multiple pregnancies were associated with an increased risk of HPV infection . A recent cross‐sectional epidemiologic survey showed a trend toward earlier sexual debut and riskier sexual behaviours in younger age groups of Chinese women, with the median age of sexual debut being 17 years .…”

Section: Discussionmentioning

confidence: 99%

Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18–25 years enrolled in a clinical trial

Zhao

Zhu

Chen

et al. 2014

Intl Journal of Cancer

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Baseline human papillomavirus (HPV) prevalence and type distribution were evaluated in young Chinese women enrolled in a clinical trial of an HPV vaccine (ClinicalTrials.gov registration NCT00779766). Cervical specimens and blood samples were collected at baseline from women aged 18–25 years (n = 6,051) from four sites across Jiangsu province. Cervical specimens were tested for HPV DNA by SPF10 PCR-DEIA-LiPA25 version 1, and HPV-16/18 type-specific polymerase chain reaction. Anti-HPV-16 and anti-HPV-18 antibody titres were quantified by enzyme-linked immunosorbent assay. At baseline, 15.3% of women were DNA positive for any of 14 HPV high-risk (hr) types (HPV-16/18/31/33/35/39/45/51/52/56/58/59/66/68). The most commonly detected hrHPV types in cervical specimens were HPV-52 (4.0%) and HPV-16 (3.7%). High-risk HPV DNA-positivity increased with severity of cytological abnormalities: 39.3% in atypical squamous cells of undetermined significance, 85.0% in low-grade squamous intraepithelial lesions and 97.8% in high-grade squamous intraepithelial lesions (HSIL). The hrHPV types most frequently detected in HSIL were HPV-16 (63.0%), HPV-18 (17.4%), HPV-52 (17.4%), HPV-58 (15.2%) and HPV-33 (15.2%). The hrHPV types most frequently detected in cervical intraepithelial neoplasia 2+ were HPV-16 (66.1%), HPV-33 (16.1%), HPV-52 (16.1%), HPV-58 (14.5%) and HPV-51 (11.3%). Multiple hrHPV infections were reported for 24.4% of hrHPV DNA positive women. Regardless of baseline HPV DNA status, 30.5% and 16.0% of subjects were initially seropositive for anti-HPV-16 and anti-HPV-18, respectively. In conclusion, the high baseline seropositivity rate and intermediate prevalence of cervical hrHPV types in Chinese women aged 18–25 years underlines the importance of early HPV vaccination in this population.What's new?In China, cervical cancer is the second most frequent cancer among women aged 15–44 years. The authors collected baseline data on prevalence and type distribution of human papillomavirus (HPV) from more than 6,000 healthy Chinese women aged 18–25 years participating in a large vaccine efficacy trial. Regardless of cytology, 15.3% of women were positive for high-risk HPV types, with HPV-52 (4.0%), HPV-16 (3.7%), HPV-51 (1.7%) and HPV-58 (1.5%) being the most frequently detected. This high baseline prevalence of high-risk HPV types underscores the importance of early vaccination among Chinese women.

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Section: Discussionmentioning

confidence: 99%

Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18–25 years enrolled in a clinical trial

Zhao

Zhu

Chen

et al. 2014

Intl Journal of Cancer

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“…23 HPV prevalence and cervical intraepithelial neoplasia (CIN) were high in young women in China. For example a study in Jiangsu Province found that among women aged 18 to 24 This study indicated cervical disease burden was relatively high among young women aged 18-25 and educational interventions targeting female adolescents and strategies to subsidize vaccine costs were needed to ensure the effectiveness of vaccination campaigns in China. Unfortunately until now the understanding of the natural history of HPV among young male populations in China is still lacking.…”

Section: Discussionmentioning

confidence: 99%

“…5 The quadrivalent vaccine (Gardasil) covers HPV 6,11,16 and 18. It is efficacious in preventing many of the above mentioned morbidities in both men and women. For example, Gardasil was efficacious to prevent nearly 100% of cervical cancers among women aged [18][19][20][21][22][23][24]6 90% of genital lesions among heterosexual men aged [16][17][18][19][20][21][22][23][24][25][26]7 78% of ano-genital warts and 75% of anal intraepithelial neoplasia among MSM. 8 Its safety was also warranted in above-mentioned populations.…”

Section: Introductionmentioning

confidence: 99%

How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China

Zou

Wang

et al. 2015

Human Vaccines & Immunotherapeutics

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The acceptability of HPV vaccination among university students in China is not well understood. Our study was of cross-sectional study design. We collected a questionnaire about socio-demographic characteristics, knowledge of, attitude toward and acceptability of HPV vaccination. A total of 351 students were included in data analyses, among whom 47.6% were males and 70.0% aged 19-21. Only 10.3% had previously heard of HPV and 5.4% HPV vaccine. Male and female students were equally likely to accept HPV vaccine (71.8 vs 69.4%, p D 0.634) and recommend it to sexual partners (73.1 vs 76.7%, p D 0.441). The great majority of students could only afford RMB 300 (USD 50) or less for HPV vaccination. HPV vaccination acceptance was associated with being in year-one (Adjusted odds ratio (AOR) D 3.78, 95% confidence interval (CI): 2.12-6.75), being from a key university (AOR D 1.88, 95%CI: 1.07-3.31), having heard of HPV-related morbidities (AOR D 1.88, 95% CI: 1.05-3.35), being concerned about HPV-related morbidities (AOR D 2.23, 95% CI: 1.16-4.27) and believing the vaccine should be given before first sexual contact (AOR D 2.44, 95% CI: 1.38-4.29). Female students were more likely to anticipate a late uptake of HPV vaccination (p D 0.002). The relatively lower levels of HPV knowledge but higher levels of vaccine acceptance among undergraduates highlighted the need for education on the roles of sexual behaviors in HPV transmission.

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“…Amongst young women in China, 3.4% were diagnosed with lesions of CIN grade 2 or worse and 17.1% tested positive for HPV DNA10. The International Agency for Research on Cancer has published several systematic reviews and is now recommending that HPV-DNA testing be used for primary screening, as an alternative to cytology2.…”

Section: Discussionmentioning

confidence: 99%

High-risk HPV nucleic acid detection kit–the careHPV test –a new detection method for screening

Hong

Fang

Zhao

et al. 2014

Sci Rep

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This study assessed the clinical accuracy of the correlation between the careHPV test and the HC2 test, as well as the correlation between the careHPV test and the HPV-PCR test. From September 21 to December 31, 2009, 419 cervical specimens from women, 30–49 years, were collected. All women were assessed by Digene HC2 High-Risk HPV DNA Test (HC2), careHPV test, and HPV-PCR. The concordance rate between careHPV and HC2 was 93.81% and between careHPV and HPV-PCR 88.12%. The sensitivity and specificity of the careHPV test to detect cancers of equal or greater severity than CIN 2 were 85.71% and 83.15% respectively. Results from careHPV, HC2, and HPV-PCR were highly consistent. The careHPV test has good sensitivity and specificity for the detection of HPV infection and is a promising primary screening method for cervical cancer in low-resource regions.

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Prevalence of HPV infection and cervical intraepithelial neoplasia and attitudes towards HPV vaccination among Chinese women aged 18–25 in Jiangsu Province

Cited by 26 publications

References 23 publications

Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18–25 years enrolled in a clinical trial

Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18–25 years enrolled in a clinical trial

How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China

High-risk HPV nucleic acid detection kit–the careHPV test –a new detection method for screening

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