Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients

Abstract

The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher

Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa

“…In the largest study on the prevalence of HPV DNA in patients with HNSCCs in South Africa, we found an HPV prevalence of 7.8%. This is low compared with other regions such as Europe, Asia, and the USA, but in agreement with the low prevalence that has been reported in developing countries, including those in sub‐Saharan Africa …”

“…This is low compared with other regions such as Europe, Asia, and the USA, but in agreement with the low prevalence that has been reported in developing countries, including those in sub-Saharan Africa. 1,12,[16][17][18][19][20][21][22][23] In a PCR-based study using FFPE tissue from patients with confirmed HNSCCs in Senegal, HPV DNA was detected in 3.4% of samples tested. 20 In a similar study performed in Ghana, 19.2% of FFPE tissues were positive, 21 while in Nigeria no HPV DNA was detected in 149 FFPE head and neck biopsies tested using the Linear Array genotyping assay.…”

Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil

“…demonstrated in a cohort of 121 patients worse survival for HPV‐negative black patients compared to HPV‐negative white patients (HR 2.21, P = 0.049) . HPV‐associated tumors are more common in white patients; accordingly, survival disparities between races in OPC are postulated to be due to the differences in biologic drivers of the disease . However, among patients with HPV‐negative disease, black patients may still have decreased survival highlighting other potential causes of racial disparities in high‐risk OPC.…”

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

“…A recent meta-analysis indicated that the incidence of HPV-related oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians [27]. Lee at al.…”