Prevalence of human papillomavirus cervical infection in an Italian asymptomatic population

Centurioni, Maria Grazia; Puppo, Andrea; Merlo, Domenico Franco; Pasciucco, Gennaro; Cusimano, Enzo R; Sirito, Rodolfo; Gustavino, Claudio

doi:10.1186/1471-2334-5-77

Cited by 30 publications

(24 citation statements)

References 28 publications

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“…It is estimated that a wide range of healthy and sexually active female population is a carrier of subclinical genital infection, contributing to the spread of the virus. The prevalence of infection among worldwide population of healthy women was estimated to be between 2% and 44% in relation to the sensitivity of the diagnostic test applied [44,47,[50][51][52]. The highest prevalence (about 40%) of HPV infection was found among women under the age of 25 years, progressively reduced in successive age groups [53].…”

Section: Genital Normal Mucosa and Hpv Infectionmentioning

confidence: 99%

“…On the basis of epidemiologic data regarding the behaviour of the viral lesions, HPV have been also divided in two groups: those at "high risk" oncogenic [High Risk (HR) -HPV genotypes like 16-18-31-33-35, 39,45,51,52,53, 56,58,59, 66, 67,70,73,68, 82), associated with potentially and overtly malignant lesions (anogenital cancers, giant condyloma of Bruschke and Lowenstein) and those at "low risk" oncogenic [Low Risk (LR)-HPV genotypes like 2, 4, 27 (the skin types) and mucosal types 6,11,13,32,42), more commonly associated with benign diseases (ordinary wart, condyloma, focal epithelial hyperplasia, squamous cells papilloma, Bowen's papillomatosis) [39][40][41][42][43]. After entry to host cell, HPV infection can manifest in two clinical states: 1) subclinical or unapparent infection, that is the silent presence of viral genome into inoculation site without any clinical and/or histological and/or cytological alterations of cervical mucosa [44]; 2) clinical infection, expression of proliferation of infected keratinocytes and associated with clinical and histological lesions of cervical mucosa. These lesions are usually benignant (e.g.…”

Section: Natural History Of Hpv Infectionmentioning

confidence: 99%

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Oral HPV Infection: Current Strategies for Prevention and Therapy

Syrjänen

Termine

Capra³

et al. 2012

CPD

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Infection with High Risk (HR) Human Papillomaviruses (HPVs) is the main aetiological agent of Cervical Squamous Cell Carcinoma (CSCC) and also associated in a subgroup of other neoplasms, including Oropharyngeal Squamous cell Carcinoma (OPSCC). HPV infection, in genital as in oral mucosa, can also be subclinical or associated with benign proliferative lesions (common warts, condylomas, papillomas) caused mostly by infection with Low Risk (LR)-HPVs. In the last decades, extensive research has resulted in growing knowledge on HPV biology and specifically viral life cycle, biochemical properties of viral proteins and their interaction with the host proteins leading to potential new targets of prophylactic or therapeutic vaccines and therapies for HPV infection. In addition, notable progresses have been made in the field of diagnostics to detect HPV DNA or RNA. The recent epidemiological data suggest the significant changes in HPV endemic, due to the changes in sexual habits especially among young generations (i.e. early sexual debuts, multiple sexual partners, oral and anal sex); this scenario has urged on the need of adequate campaigns of primary (sexual education, vaccination programs) and secondary prevention (diagnostics of HPV-related diseases). Due to the growing interest on HPV infection and HPV related cancers, the authors made a narrative review of the literature on oral HPV infection and oral-genital transmission. After this, in view of the controversies about the strategies of therapy and prevention of HPV infection, the present review focuses on the current state of art about the available tools for the therapeutic and, if any, preventive management of oral HPV infection.

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Section: Genital Normal Mucosa and Hpv Infectionmentioning

confidence: 99%

Section: Natural History Of Hpv Infectionmentioning

confidence: 99%

Oral HPV Infection: Current Strategies for Prevention and Therapy

Syrjänen

Termine

Capra³

et al. 2012

CPD

View full text Add to dashboard Cite

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“…The decreased occurrence with increasing age may suggest that the HPV infection at a young age is transient and it is eradicated by the immune-system. For the same reason not all HPV-infected women develop cervical abnomarlities (Centurioni et al, 2005, Onuki et al, 2009). The most common HPV genotype in either single or multiple infections was HPV16 followed by HPV18.…”

Section: Western Asiamentioning

confidence: 99%

Human Papillomavirus Worldwide Distribution in Women Without Cervical Cancer

Dutra¹,

Foroni²,

Couto³

et al. 2012

Human Papillomavirus and Related Diseases - From Bench to Bedside - Research Aspects

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“…Over 170 types of HPV types have been identified [5], more than 50 of which typically infect the human anogenital tract [6]. On the basis of their association with cervical carcinogenesis, HPV genotypes are classified as either high risk (HPV16, 18,31,33,35,39,45,51,52,56,58,59,68,73,82) or low risk (HPV6, 11,40,42,43,44,54,61,70,72,81) [7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

Dandal

Abajy

Alkhalaf

et al. 2017

Int J Pharm Pharm Sci

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Objective: Cervical cancer is the second common type of cancer among women worldwide. Infection by certain types of human papillomavirus infection (HPV) such as HPV 16/18 has been considered as the most significant risk factor for the development of cervical cancer. This study was conducted to determine the prevalence HPV 16/18 in women with and without cervical cancer in Aleppo city, Syria.Methods: Paraffin embedded cervical tissue samples were collected from 113 patients and 40 controls (normal cervix), DNA was extracted and analyzed by PCR for the presence of HPV16/18. Out of 113 cases of cervical carcinoma, 25 cases (22.1%) were carcinoma in situ (CIS), 72 cases (63.7%) were squamous cell carcinomas (SCC) and 16 cases (14.2%) were adenocarcinoma (ADC).Results: HPV 16 and/or 18 DNA was detected in 84 (74.3%) cases out of 113 of cervical cancers, while it was found in only two of the 40 samples in the control group. At the same time, 9 out of 25 (36%) carcinoma in situ, 61 out of 72(84.72%) squamous cell carcinomas, and 14 out of 16 (87.5%) adenocarcinomas, were positive for HPV 16 and/or 18. Conclusion:The frequency of infection with HPV 16 and 18 is high among Syrian women and a vaccine against these two types may be effective in about 74% of cervical cancers in Syria.

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Prevalence of human papillomavirus cervical infection in an Italian asymptomatic population

Cited by 30 publications

References 28 publications

Oral HPV Infection: Current Strategies for Prevention and Therapy

Oral HPV Infection: Current Strategies for Prevention and Therapy

Human Papillomavirus Worldwide Distribution in Women Without Cervical Cancer

Prevalence of Human Papilloma Virus Types 16 and 18 Among Women With Cervical Cancer in Aleppo, Syria

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