Prevalence of human papillomavirus infection among 71,435 women in Jiangxi Province, China

Abstract

Cervical cancer is the third most common cancer in women worldwide. Human papillomavirus (HPV) has been identified as an etiological factor for cervical cancer. Data on the prevalence and subtype distribution of HPV infection in Jiangxi Province are incomplete. In this study, we investigated HPV subtype distribution and prevalence in Jiangxi Province between August 1, 2010, and December 31, 2015. A total of 71,435 individuals ranging in age from 16 to 77 years were recruited. Cervicovaginal swabs were collected from each participant, and HPV screening was performed. Our results showed that the HPV prevalence was 22.49% in Jiangxi Province. Overall, 14.99% of individuals were positive for a single HPV type, and 7.49% were positive for multiple types. The most frequently detected low-risk genotypes were HPV-6, and high-risk genotypes were HPV-16, -18, -33, -52, and -58. The prevalence and type distribution of HPV infection exhibits regional and age differences; Yingtan had the highest incidence for high-risk HPV infection (32.00%), and peaks in the frequencies of HPV infections were seen for patients under 20 and over 60 years of age. In conclusion, we present data showing that the HPV prevalence varies significantly with age and regions in Jiangxi Province. These results can serve as valuable reference to guide Jiangxi cervical cancer screening and HPV vaccination programs.

Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

“…In addition, for hr‐HPV genotypes, the 5 common subtypes in decreasing order were HPV 16, 52, 58, 33, and 18. The results of this study are similar to other literature . While other researches suggested that the most frequent HPV genotypes of HSIL were HPV 16, 58, and 18; HPV 16 and 52; and HPV 53, 58, and 52 in Sichuan, Shanxi, and Korea, respectively .…”

“…The previous studies from different areas in China proved that the overall HPV infection rates were 22.4%, 38.3%, 17.6%, and 24.1%, respectively. However, our research suggested that the overall prevalence of HPV infection was 74.0% among the HSIL and ICC women.…”

“…However, in different countries and regions, the distribution of HPV genotypes in cervical cancer and precancerous lesion varies was different . Many studies proved that the genotype distribution of HPV differed in the various provinces of China . The most frequent hr‐HPV genotypes were HPV 16 and HPV 58, HPV 52 and HPV 16, HPV 16 and HPV 18, and HPV 16 and HPV 52 in Shanxi, Sichuan, Jiangxi, and Fujian province, respectively.…”

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

“…All above findings of our study indicated that in addition to HPV16, 18, 6, and 11, HPV vaccines in Guangdong should also include HPV31, 33, 39, 52, 53, 58, 68, and CP8304 genotypes. In addition, HPV screening programs in China aim to detect only HPV6, 11, 16, and 18 . When considering the HPV distribution in Guangdong from our study, HPV screening systems should focus on HPV52, 58, 53, and 39 equally to HPV16 and 18.…”

“…It is possible that nonvaccine HPV genotypes may displace HPV vaccine genotypes as causal agents of cervical cancer and precancerous lesions in vaccinated populations . In addition, HPV screening programs in China aim to detect only HPV6, 11, 16, and 18 . Thus, regional data on the type‐specific HPV prevalence and distribution in women of different populations are essential.…”