Prevalence of human papillomavirus types in North and Central regions of Mexico

Luna-Aguirre, C. M.; Reyes-Cortes, Luisa M.; Torres-Grimaldo, A. A.; Karr-de-León, S. F.; Cerda‐Flores, Ricardo M.; Melo-Nava, B.; Aizpuru-Akel, V. E.; Barrera-Saldaña, Hugo A.

doi:10.1017/s0950268818001747

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…Moreover, a report in the east coast state of Michoacan showed that HPV59 was the prevalent genotype in single infections, followed by HPV51 and HPV45 [17]. In contrast, a study in north-eastern (NE) and south-central (SC) Mexico showed that HPV 16 frequency is the highest among males and females with genital lesions; however, clear differences in frequency were emphasized (37.5% in NE versus 14.3% in SC) [18]. All the adding evidence awareness that HPV vaccination strategies in Mexico should be geographically specific.…”

Section: Discussionmentioning

confidence: 98%

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

Rangel-Guerrero¹,

Basilio

Rocío

et al. 2020

SN Compr. Clin. Med.

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Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and a necessary condition for cervical cancer (CeCa) development. HPV types 16 and 18 are the most common in cervical lesions (CLs); therefore, specific vaccines have reduced cervical neoplasia. In 2015, HPV16 presented the highest frequency in CLs (~28%); however, types 31, 45, 52, and 58 were also detected, suggesting that other HPV types may have impact on healthcare. Here, we typified 30 patients with CLs from the "Hospital Regional 1°de Octubre" (HR1O), in Mexico City, for the most reported high-risk papillomavirus (HPV16, 18, 31, 33, 45, 58, and 59). The results showed that HPV16 frequency is dissimilar to international and previous national data, suggesting that a deeper knowledge of HPV type distribution is required before choosing a vaccination scheme for HPV in Mexico City.

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Section: Discussionmentioning

confidence: 98%

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

Rangel-Guerrero¹,

Basilio

Rocío

et al. 2020

SN Compr. Clin. Med.

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“…In south-central Mexico HPV-52 was the most prevalent, followed by HPV-16. 15 Likewise, in northeast Mexico, 59% of samples were positive for at least one HPV genotype, and HPV-16 was the most prevalent genotype, followed by HPV-18. 16 In a study conducted in healthy women in Acapulco, in the state of Guerrero, located in southern Mexico, the prevalence of HPV was 37.6%.…”

Section: Introductionmentioning

confidence: 94%

Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico

et al. 2022

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Background Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide Objective We assessed the prevalence and distribution of HPV types and their association with precancerous lesions and CC. Methods HPV genotypes were detected by 3 methods depending on the year of in which the sample was analyzed: MY09/11 RFLPs (1997 to 2010), GP5+/6+ primer systems (2005 to 2010) and INNO-LiPA HPV Genotyping Extra (2010 to 2019) in cervical samples (No-IL: 4445; LSIL: 2464; HSILs: 151 and CC: 253) from women from southern Mexico. Results The overall HPV prevalence was 54.17%, and hpv-16 was the most common genotype. In single infection, the high-risk HPV genotypes (group 1) were associated with squamous intraepitelial lesions (LSIL: HPV–39 (OR = 10.58, 95% CI 4.09–27.36, P < .001); HSIL: HPV-31 (OR = 14.76, 95% CI 6.56–33.20, P < .001); and CC: HPV-16 (OR = 25.01, 95% CI 18.83–33.21, P < .001). In multiple infections, the HPV genotypes (HPV-16 and HPV-18) were also associated with a high risk of lesions [LSIL: HPV-18 (OR = 3.45; 95% CI 1.36–8.91; P = .009); HSIL: HPV-18 (OR = 5.12; 95% CI 1.21–21.68; P = .026); and CC: HPV-16 (OR = 3.03; 95% CI 1.72–5.32; P < .001)] compared to single infection. In the analysis adjusted for age, giving birth, and cigarette smoking, a significant increase in the risk of LSIL, HSIL, and CC was maintained. Conclusions This study provides current data on the prevalence and distribution of HPV genotypes in women from southern Mexico, which could serve as a valuable reference to guide nationwide CC screening programs and provide scientific evidence that could be useful for vaccine development efforts. Likewise, it was identified that infection with carcinogenic HPV genotypes is an independent risk factor for LSIL, HSIL, and CC.

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“…Finally, we observed a high frequency of multiple infections with HPV53 as the most frequent type, this could be due to multiple factors, among which the socioeconomic and demographic characteristics of the Canatlán population stand out. This community is mainly rural and registers a high rate of migration of agricultural workers to the United States and other agricultural regions of Mexico, the movement of these individuals could favor the entry of different HPV genotypes that are not frequent among the resident population (Luna-Aguirre et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Identification of Multiple High-Risk Human Papillomavirus Infections in a Rural Population of Canatlan, Durango, Mexico

Favela-Bueno

Pérez‐Morales

Ramirez-Torres

et al. 2020

Genetic Testing and Molecular Biomarkers

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Background: The human papillomavirus (HPV) is the most frequent etiological agent driving development of cervical cancer (CC); therefore typing and classifying the status of these infections are of great importance for treatment. The frequency of the various HPV types may change in relation to low-grade lesions and have the potential to cause more severe lesions. Objective: The purpose of this study was the identification and typing of HPV in a rural population in Mexico. Methods: Detection and typing were determined by PCR-RFLPs and confirmed by viral DNA sequencing. Results: HPV was detected in 17.28% of the samples, this was 3.58% higher than had been determined in a rural population in Central Mexico. Viral types 16, 18 and 52 were found most frequently. Analysis of all HPVpositive samples revealed that 14.3% had a single infection; 57.1% had a double infection; and 28.6% had a triple infection. Thus, 85.7% of positive cases presented with multiple infections with HPV16 being the most prevalent. Only the lifetime number of sexual partners was found to have an association with the colposcopic diagnoses (OR = 7.08; 95% CI: 1.68-29.8; p > 0.008). Conclusion: A higher frequency of multiple HPV infections was found among our test population compared to other rural populations in Durango and Central Mexico. HPV type 16 was the most frequent infection.

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Prevalence of human papillomavirus types in North and Central regions of Mexico

Cited by 8 publications

References 18 publications

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

A Pilot Study on the HPV Type Frequency in a Federal High-Specialty Hospital of Mexico City: Is HPV16 Our Main Problem?

Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico

Identification of Multiple High-Risk Human Papillomavirus Infections in a Rural Population of Canatlan, Durango, Mexico

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