Prevalence of hyperprolactinemia in infertile cases and its correlation with TSH in a rural set up hospital

Agrawal, Mahima; Samal, Swarnalata; Hariharan, C.; Agrawal, Sweta

doi:10.5455/2320-1770.ijrcog20131227

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…PRL-secreting adenomas can also be a cause of hyperprolactinemia which can lead to infertility. This condition is generally treated with dopamine receptor agonist cabergoline and bromocriptine to restore fertility [ 60 ]. Elevated PRL due to any reason can cause HH and infertility.…”

Section: H Yperprolactinemia and Infertilitymentioning

confidence: 99%

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights

Koyyada

Orsu

2020

Tzu Chi Med J

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Thyroid disorders are the most common endocrine problems in women. In most of the cases, thyroid can lead to infertility or miscarriages. The etiology of infertility is multifactorial with thyroid disorders as the most common presenting factor, hypothyroidism in particular. Infertility in women can lead to emotional and psychological stress. The prevalence of hypothyroidism during pregnancy is estimated to be 0.3%–0.5%. Hypothyroidism and hyperthyroidism can result in menstrual irregularities and anovulatory cycles, thus affecting the fertility. There is a significant high prolactin (PRL) level in infertile women with hypothyroidism when compared to euthyroid patients, indicating the relation between hypothyroidism and hyperprolactinemia. The amount of thyrotropin releasing hormone (TRH) from the hypothalamus is markedly increased by inhibition of pyroglutamyl peptidase II, the enzyme catalyzing TRH. The increased TRH in hypothyroidism causes increased thyroid-stimulating hormone and PRL secretion by pituitary, leading to infertility and galactorrhea. In recent years, a neuropeptide called kisspeptin, encoded by Kiss1 gene, a potent stimulus for GnRH secretion, has been recognized, which suggests a future direction of treatment with kisspeptin and benefits the fertility induction among hyperprolactinemic infertile patients. Untreated hypothyroidism during pregnancy can lead to subfertility, fetal deaths, premature deliveries, and abortions. Therefore, women planning for pregnancy and infertile women should be assessed for thyroid hormones and serum PRL.

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Section: H Yperprolactinemia and Infertilitymentioning

confidence: 99%

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights

Koyyada

Orsu

2020

Tzu Chi Med J

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“…Among 130 females ,16 females with primary subfertility and out of 70 women with secondary subfertility, 7 had serum prolactin >25 ng/ml. S. prolactin was > 75 ng/ml in 1 patient of primary infertility and zero in the secondary infertility 13 In a local study conducted in Pakistan, the prevalence of infertility in hyperprolactinemic women was 69.51 % 184 . Morris and Sauer 185 noticed 23 to 25 % subfertile women had raised prolactin levels and 26 to 28 % was reported by a study conducted in india 14 .…”

Section: Discussionmentioning

confidence: 93%

Prevalence of High Prolactin Levels in Subfertile Females of South Punjab, Pakistan

Malik¹,

Khan²,

Zahra³

et al. 2022

PJMHS

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Objective: To find out the prevalence of hyperprolactinemia in subfertile females attending outpatient department (OPD) in a tertiary care hospital of South Punjab, Pakistan Design: Cross sectional Setting: Gynaecological outpatient department (OPD) Nishtar Hospital Multan, Pakistan Duration of study: Six months Subjects and methods: After approval from the hospital ethical committee, 379 patients, who meet the set standards, having primary and secondary subfertility, were included from Gynae outpatient department (OPD) of Nishtar Hospital Multan. After informed consent, serum prolactin level was measured of all selected women. Data was entered into a computer using SPSS version 10 for Windows. Results: Most women (39.05%) were 26-30 years old and were nullipara. BMI > 30 was observed in 21.89% of cases. Majority of patients (66.75%) were having primary subfertility. Secondary subfertility was reported in 33.24% of cases. Duration of subfertility was < 5 years in 63.06% of patients and in 36.93% of cases duration of subfertility was ≥5 years. Frequency of hyperprolactinemia in subfertile women was 29.28%. Conclusion: Hyperprolactinemia causes anovulatory cycles because of suppression of endogenous gonadotrophins and it is commonly encountered in patients who primarily find unable to conceive as compared to those who have previously conceived. Keywords: High prolactin levels, primary infertility, secondary subfertility, prolactinoma.

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“…This was agreed with (Turankar et al, 2016), who achieved their study in India to study the serum prolactin levels and the serum TSH in primary infertile females, and illustrated that the serum prolactin concentration was increased in the infertile group (54.38 ±11.34) as compared to that in the control group (18.14± 5.99) and it was found to be statistically highly significant (p<0.0001). Also (Agrawal et al, 2013), who implemented their study in India to find out the incidence of hyperprolactinemia in infertility and highlight the importance of assessment of serum TSH level in hyperprolactinemia, and concluded that hyperprolactinemia was a common finding in an infertile women. This confirms the relation between hyperprolactinemia and infertility.…”

Section: Discussionmentioning

confidence: 99%

Nurse's role in the management of hyperprolactinemia: a prospective randomized controlled trial

Hassan

Darwish

Ahmed

et al. 2022

Assiut Scientific Nursing Journal

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Background: Hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood. Normal levels are [20-25 ng/mL or μg/L] for women; Hyperprolactinaemia can also be a part of normal body changes during pregnancy and breastfeeding. Aim: To evaluate the impact of the nurse's role on the management of hyperprolactinemia, Sampling: convenient sample included 100 women started from April 2019 to March 2020. Research design: A Prospective study (randomized controlled trial) was utilizied in this study. Setting: The study was conducted at the laboratory (Woman's Health Hospital lab, Assiut University). Results: It is illustrated that there is statistical significant difference between the study and the control groups regarding prolactin value, as the majority of studied women have a normal value in the study and abnormal value in the control groups p-value 0.001. Conclusion:The nurse carry a vital role for hyperprolactinemia through health education including (feeding habits, Life style and sexual behaviors). in assessing and managing hyperprolactinemia. and thus increase the quality of life. Recommendations: support the nurses's role in assessing and managing hyperprolactinemia through providing a counseling that needed to women

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Prevalence of hyperprolactinemia in infertile cases and its correlation with TSH in a rural set up hospital

Cited by 5 publications

References 14 publications

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights

Prevalence of High Prolactin Levels in Subfertile Females of South Punjab, Pakistan

Nurse's role in the management of hyperprolactinemia: a prospective randomized controlled trial

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