Prevalence of Inflammatory Bowel Disease Among Patients with Autism Spectrum Disorders

Doshi‐Velez, Finale; Avillach, Paul; Palmer, Nathan; Bousvaros, Athos; Ge, Yaorong; Fox, Kathe; Steinberg, Greg; Spettell, Claire M.; Juster, Iver A.; Kohane, Isaac S.

doi:10.1097/mib.0000000000000502

Cited by 32 publications

(42 citation statements)

References 27 publications

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“…Some studies found an association between gastrointestinal symptoms and severity of ASD symptoms (Adams et al, 2011;Wang L. W. et al, 2011;Mazurek et al, 2013), but others could not reproduce these findings (Kang et al, 2013;Son et al, 2015). ASD patients appear to have a higher prevalence of IBD (Doshi-Velez et al, 2015) and a higher number of pro-inflammatory immune cells in the intestinal wall (Navarro et al, 2016), although intestinal inflammatory markers, such as fecal calprotectin, appear normal (Navarro et al, 2016). The gastrointestinal symptoms may be caused by the presence of more pro-inflammatory gut bacteria (Fattorusso et al, 2019), but other factors may also be involved (Mayer et al, 2014).…”

Section: Neurological Disorders With Fmt Studies In Both Patients Andmentioning

confidence: 99%

Fecal Microbiota Transplantation in Neurological Disorders

Vendrik

Ooijevaar

Jong

et al. 2020

Front. Cell. Infect. Microbiol.

281

174

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Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.

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Section: Neurological Disorders With Fmt Studies In Both Patients Andmentioning

confidence: 99%

Fecal Microbiota Transplantation in Neurological Disorders

Vendrik

Ooijevaar

Jong

et al. 2020

Front. Cell. Infect. Microbiol.

281

174

View full text Add to dashboard Cite

show abstract

“…31 Clinically, gastrointestinal complaints and increased incidence of inflammatory bowel disease (IBD) have been commonly reported with autism spectrum disorder (ASD). 32,33 One study comparing the intestinal microbiome of ASD patients to controls demonstrated alterations specifically in Clostridia and Bacteroidetes , Desulfovibrio classes. 34 Further study revealed increased levels of propionic acid (PPA), a short chain fatty acid fermentation product of Clostridia and Bacteroidetes, Desulfovibrio .…”

Section: Microbiota-gut-brain Axismentioning

confidence: 99%

The Developing Microbiome of the Preterm Infant

DiBartolomeo

Claud

2016

Clinical Therapeutics

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Purpose The importance of the neonatal microbiome in intestinal and overall health Method Review of existing literature Findings and Implications The Microbiome is increasingly understood to have a significant role in health and disease. However, the microbiome of the preterm infant is unique, with simple microbial communities exposed to a consistent diet in a regulated environment, and development from naïve to stable under the influence of the neonatal intensive care unit. This early microbiome encounters a still developing host and thus has the potential to program fundamental pathways with implications for neonatal as well as later outcomes.

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“…However, a majority of children with ASD also suffer from a wide range of systemic aberrations such as increased serum serotonin (40% prevalence) [1–3], gastrointestinal (GI) distress (up to 90%) [4], and inflammatory bowel disease (IBD) [5]. Unfortunately, the causative agent for those conditions and their relationship with etiology and pathogenesis of ASD remains undefined.…”

Section: Introductionmentioning

confidence: 99%

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia

Lim

Choi

et al. 2017

Mol Brain

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Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that are sharply increasing in prevalence worldwide. Intriguingly, ASD is often accompanied by an array of systemic aberrations including (1) increased serotonin, (2) various modes of gastrointestinal disorders, and (3) inflammatory bowel disease (IBD), albeit the underlying cause for such comorbidities remains uncertain. Also, accumulating number of studies report that the gut microbial composition is significantly altered in children with ASD or patients with IBD. Surprisingly, when we analyzed the gut microbiota of poly I:C and VPA-induced mouse models of ASD, we found a distinct pattern of microbial dysbiosis that highly recapitulated those reported in clinical cases of ASD and IBD. Moreover, we report that such microbial dysbiosis led to notable perturbations in microbial metabolic pathways that are known to negatively affect the host, especially with regards to the pathogenesis of ASD and IBD. Lastly, we found that serum level of serotonin is significantly increased in both poly I:C and VPA mice, and that it correlates with increases of a bacterial genus and a metabolic pathway that are implicated in stimulation of host serotonin production. Our results using animal model identify prenatal environmental risk factors of autism as possible causative agents of IBD-related gut microbial dysbiosis in ASD, and suggest a multifaceted role of gut microbiota in the systemic pathogenesis of ASD and hyperserotonemia.Electronic supplementary materialThe online version of this article (doi:10.1186/s13041-017-0292-0) contains supplementary material, which is available to authorized users.

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Prevalence of Inflammatory Bowel Disease Among Patients with Autism Spectrum Disorders

Abstract: Across each population with different kinds of ascertainment, there was a consistent and statistically significant increased prevalance of IBD in patients with ASD than their respective controls and nationally reported rates for pediatric IBD.

Cited by 32 publications

References 27 publications

Fecal Microbiota Transplantation in Neurological Disorders

Fecal Microbiota Transplantation in Neurological Disorders

The Developing Microbiome of the Preterm Infant

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia

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