Prevalence of Inflammatory Markers (High-Sensitivity C-Reactive Protein, Nuclear Factor-κB, and Adiponectin) in Indian Patients with Type 2 Diabetes Mellitus with and without Macrovascular Complications

Misra, Durga Prasanna; Das, Sidhartha; Sahu, Pratima Kumari

doi:10.1089/met.2011.0044

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…Such proinflammatory state could be an independent determinant of atherosclerosis in this population. Further, this study has shown that persons with DM had significantly higher cholesterol and TG levels than non-DM counterparts [30].…”

Section: Discussionmentioning

confidence: 54%

Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

Behera¹,

Behera²,

Das³

et al. 2017

JDM

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Background: Data regarding the prevalence of morbidity and mortality in patients of Type 2 Diabetes Mellitus (T2DM) is scanty in India. Objectives: To determine the prevalence of micro and macro vascular complications, acute metabolic complications, infections, Non Alcoholic Fatty Liver Disease (NAFLD) and cause of mortality in T2DM patients admitted to a tertiary care teaching hospital in Eastern India. Material and Methods: This was a hospital-based prospective study evaluating 150 T2DM patients admitted to a tertiary care institution in Eastern India. Diagnosis of micro and macro vascular complications, infections and NAFLD was made using standard protocols. In case of death, the most probable cause was noted. Results: Out of 150 patients, 14.7% of patients were newly diagnosed T2DM and out of them 41% of patients had vascular complications and 54.5% had infections. Of the total patients, 56% had nephropathy, 20% neuropathy, 17.3% retinopathy, 31.3% CVD, 11.3% CAD, 4.6% acute metabolic complications, 44% infections and 16.6% had NAFLD respectively. Macrovascular events occured earlier than microvascular complications. Multiple logistic regression analysis showed strong association of age, duration of diabetes, serum cholesterol, triglyceride, LDL-C with 196cause (51.5%: CVD 36.4%, CAD 15.1%) to be followed by infections (27.3%) and then chronic kidney disease (12.1%). Conclusions: This study highlights the high prevalence of vascular complications and infections in T2DM patients of Eastern India. CV-related deaths were principal causes of death, similar to that in developed world.

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Section: Discussionmentioning

confidence: 54%

Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

Behera¹,

Behera²,

Das³

et al. 2017

JDM

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“…Definition of diabetic foot infections (Table 8) indicate infectious diabetic foot as a "clinical syndrome characterized by the presence of local signs of inflammation such as redness, warmth, induration, pain or tenderness and purulence, sometimes in the context of a framework of sepsis, that occurs in a site below the malleoli in a person with diabetes" [61] . Infections on diabetic foot can represent a common and dangerous complication of diabetes owing to the fact that they can involve deeper soft and bone tissuse (cellulitis and osteomyelitis) thus significantly increasing the risk of amputation.…”

Section: Infections In Patients With Dfsmentioning

confidence: 99%

Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

Tuttolomondo

Maida

Pinto

2015

WJO

125

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“…The pathways between negative and positive emotions and health outcomes interact through behavioral and/or biological mediators, both of which have relevance for DM, an illness characterized by underlying inflammatory changes [32,33] . Negative emotions can intensify a variety of health threats.…”

Section: Health Effects Of Emotions?mentioning

confidence: 99%

Psychological aspects of diabetes care: Effecting behavioral change in patients

Chew

Sazlina

Fernandez

2014

WJD

109

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Patients with diabetes mellitus (DM) need psychological support throughout their life span from the time of diagnosis. The psychological make-up of the patients with DM play a central role in self-management behaviors. Without patient's adherence to the effective therapies, there would be persistent sub-optimal control of diseases, increase diabetes-related complications, causing deterioration in quality of life, resulting in increased healthcare utilization and burden on healthcare systems. However, provision of psychosocial support is generally inadequate due to its challenging nature of needs and demands on the healthcare systems. This review article examines patient's psychological aspects in general, elaborates in particular about emotion effects on health, and emotion in relation to other psychological domains such as cognition, self-regulation, self-efficacy and behavior. Some descriptions are also provided on willpower, resilience, illness perception and proactive coping in relating execution of new behaviors, coping with future-oriented thinking and influences of illness perception on health-related behaviors. These psychological aspects are further discussed in relation to DM and interventions for patients with DM. Equipped with the understanding of the pertinent nature of psychology in patients with DM; and knowing the links between the psychological disorders, inflammation and cardiovascular outcomes would hopefully encourages healthcare professionals in giving due attention to the psychological needs of patients with DM. Key words: Psychology; Psychosocial aspects; Emotions; Cognition; Distress; Depression; Psychological resilience; Self-care; Coping behaviors; Quality of life; Diabetes mellitus Core tip: Positive psychological health may sustain long-term coping efforts and protect patients from the negative consequences of prolonged emotional disorders, illness perception and thus facilitating diabetes self-management behaviors and better physical health. Having patients acquire valued personal beliefs and achievable standards of performance could strengthen self-regulation and self-efficacy leading to more positive experience and healthy behaviors. Furthermore, improved personal resources such as resilience would lead to better functioning of cognition and stronger will power, quality of life and disease control in patients with diabetes mellitus.Chew BH, Shariff-Ghazali S, Fernandez A. Psychological aspects of diabetes care: Effecting behavioral change in patients. World J Diabetes 2014; 5(6): 796-808 Available from:

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Prevalence of Inflammatory Markers (High-Sensitivity C-Reactive Protein, Nuclear Factor-κB, and Adiponectin) in Indian Patients with Type 2 Diabetes Mellitus with and without Macrovascular Complications

Abstract: Indian subjects with T2DM with or without MVD had higher hsCRP and lower adiponectin values as compared to healthy controls, whereas hsCRP was significantly higher in those with MVD, suggesting that our patients with T2DM were in a proinflammatory state.

Cited by 21 publications

References 16 publications

Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

Psychological aspects of diabetes care: Effecting behavioral change in patients

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