Prevalence of Left Ventricular Noncompaction in Newborns by Echocardiography: Is This the Most Accurate Approach?

Towbin, Jeffrey A.; Johnson, Jason N.

doi:10.1161/circimaging.122.014416

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…The developmental transition from the highly trabeculated wall to one dominated by compact myocardium has mostly been investigated in a biomedical context to give perspectives to so‐called noncompaction (Freedom et al, 2005; MacGrogan et al, 2018; Sedmera et al, 2000; Shi et al, 2023; Wilsbacher & McNally, 2016). Since noncompaction presupposes compaction, the increasing interest in noncompaction (Finsterer et al, 2017; Hussein et al, 2015; Towbin & Johnson, 2022) has likely led to a misattributed and exaggerated importance to compaction (D'Silva & Jensen, 2020; Faber, D'Silva, et al, 2021; Henderson & Anderson, 2009; Petersen et al, 2023). In biology, shape change is often driven by differential growth rates (Gould, 1966), and this is also the case for the pig, as we show here, and in human, mice, and chicken (Faber et al, 2022), and even in animals with an almost “smooth” RV ventricular wall such as shrews (Chang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…These embryonic trabeculations will give rise to papillary muscles, trabeculations or trabeculae carneae, Purkinje cells, and, perhaps, compact wall in the fetal period (Christoffels & Moorman, 2009; Henderson & Anderson, 2009; Miquerol et al, 2010; Sedmera et al, 2003). If trabeculations are added to the compact wall, besides a reduction in their number, there should also be a reduction in the ventricular cavity in between trabeculations, the intertrabecular recesses (Towbin & Johnson, 2022). Compaction, however, may be a subtle process only in mammals (Faber, D'Silva, et al, 2021) not withstanding compaction seems to be a major driver of early ventricular septation in chicken and lizard (Hanemaaijer et al, 2019; Rychterova, 1971).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Jensen,

Salvatori,

Schouten

et al. 2024

Clinical Anatomy

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An intricate meshwork of trabeculations lines the luminal side of cardiac ventricles. Compaction, a developmental process, is thought to reduce trabeculations by adding them to the neighboring compact wall which is then enlarged. When pig, a plausible cardiac donor for xenotransplantation, is compared to human, the ventricular walls appear to have fewer trabeculations. We hypothesized the trabecular volume is proportionally smaller in pig than in human. Macroscopically, we observed in 16 pig hearts that the ventricular walls harbor few but large trabeculations. Close inspection revealed a high number of tiny trabeculations, a few hundred, within the recesses of the large trabeculations. While tiny, these were still larger than embryonic trabeculations and even when considering their number, the total tally of trabeculations in pig was much fewer than in human. Volumetrics based on high‐resolution MRI of additional six pig hearts compared to six human hearts, revealed the left ventricles were not significantly differently trabeculated (21.5 versus 22.8%, respectively), and the porcine right ventricles were only slightly less trabeculated (42.1 vs 49.3%, respectively). We then analyzed volumetrically 10 pig embryonic hearts from gestational day 14–35. The trabecular and compact layer always grew, as did the intertrabecular recesses, in contrast to what compaction predicts. The proportions of the trabecular and compact layers changed substantially, nonetheless, due to differences in their growth rate rather than compaction. In conclusion, processes that affect the trabecular morphology do not necessarily affect the proportion of trabecular‐to‐compact myocardium and they are then distinct from compaction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Jensen,

Salvatori,

Schouten

et al. 2024

Clinical Anatomy

View full text Add to dashboard Cite

show abstract

“…The developmental transition from the highly trabeculated wall to one dominated by compact myocardium has mostly been investigated in a biomedical context to give perspectives to so-called noncompaction [37,61,[66][67][68]. Since noncompaction presupposes compaction, the increasing interest in noncompaction [17,27,69] has likely led to a misattributed and exaggerated importance to compaction [13,18,46]. In biology, shape change is often driven by differential growth rates [70], and this is also the case for the pig, as we show here, and in human, mice, and chicken [21], and even in animals with an almost 'smooth' ventricular wall such as shrews [54].…”

Section: Discussionmentioning

confidence: 99%

“…These embryonic trabeculations will give rise to papillary muscles, trabeculations or trabeculae carneae, Purkinje cells, and, perhaps, compact wall in the fetal period [13][14][15][16]. If trabeculations are added to the compact wall, besides a reduction in their number, there should also be a reduction in the ventricular cavity in between trabeculations, the intertrabecular recesses [17]. Compaction, however, may be a subtle process only in mammals [18] not withstanding compaction seems to be a major driver of early ventricular septation in chicken and lizard [19,20].…”

Section: Introductionmentioning

confidence: 99%

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Jensen,

Salvatori,

Schouten

et al. 2023

Preprint

View full text Add to dashboard Cite

An intricate meshwork of trabeculations lines the luminal side of cardiac ventricles. Compaction, a developmental process, is thought to reduce trabeculations by adding them to the neighboring compact wall which is then enlarged. When pig, a plausible cardiac donor for xenotransplantation, is compared to human, the ventricular walls appear to have fewer trabeculations. We hypothesized the trabecular volume is proportionally smaller in pig than in human. Macroscopically, we observed in sixteen pig hearts that the ventricular walls harbor few but large trabeculations. Close inspection revealed a high number of tiny trabeculations, a few hundred, within the recesses of the large trabeculations. While tiny, these were still larger than embryonic trabeculations and even when considering their number, the total tally of trabeculations in pig was much fewer than in human. Volumetrics based on high-resolution MRI of additional six pig hearts compared to six human hearts, revealed the left ventricles were not significantly differently trabeculated (21.5 versus 22.8%, respectively), and the porcine right ventricles were only slightly less trabeculated (42.1 versus 49.3%, respectively). We then analyzed volumetrically ten pig embryonic hearts from gestational day 14 to 35. The trabecular and compact layer always grew, as did the intertrabecular recesses, in contrast to what compaction predicts. The proportions of the trabecular and compact layers changed substantially, nonetheless, due to differences in their growth rate rather than compaction. In conclusion, processes that affect the trabecular morphology do not necessarily affect the proportion of trabecular-to-compact myocardium and they are then distinct from compaction.

show abstract

Prevalence of Left Ventricular Noncompaction in Newborns by Echocardiography: Is This the Most Accurate Approach?

Cited by 2 publications

References 22 publications

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

Trabeculations of the porcine and human cardiac ventricles are different in number but similar in total volume

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