Prevalence of Lung Lesions at Autopsy: A Histopathological Study

Khare, Pratima; Gupta, Renu; Ahuja, Mukta; Khare, Nupur; Agarwal, Swapnil; Bansal, Deepti

doi:10.7860/jcdr/2017/24747.9827

Cited by 15 publications

(26 citation statements)

References 5 publications

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“…2,3,5,6 Emphysematous changes were seen in 15(4.31%) cases in present study which is consistent with Chauhan G et al, Amin NS et al and Khare P et al 7.76%, 6.6% and 8.75% cases respectively. 3,6,11 Among the extra pulmonary cause of death in which lung showed associated findings were most commonly of edema, congestion, CVC in 53.16% cases in our study. This is comparable to study done by Udayashankar SK et al Chauhan G et al and Bal MS et al which showed 54.54%, 54.32% and 58% cases respectively.…”

Section: Discussionmentioning

confidence: 79%

Pattern of histopathological lesions in lung autopsy

Patel

Bhagat

et al. 2017

Int J Res Med Sci

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Background: A large number of pathologic conditions involve the lung parenchyma like inflammatory, neoplastic and others. The lungs are also involved in almost all terminal events of cardiovascular disease. Autopsy is an important and most useful way to find out the condition of internal organs and to evaluate any localized lesions or systemic disease and hence determine cause of death. Aims and objectives of study are to identify the histopathological spectrum of lung disease. To find out frequency of various lung pathologies in respect to age and sex.Methods: This study was retrospective and done on 649 cases of medico legal autopsies. The tissue specimens were fixed and processed. Routine paraffin sectioning was done followed by Hematoxylene and eosin (H and E) staining. Special stains were done whenever required. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.Results: After thorough histopathological examinations, of total 649 cases, various pulmonary lesions were identified in 348(53.6%) cases while in 301(46.4%) cases no significant pathology was seen. Most commonly affected age group was 30-49 years 43.1% followed by age group of >60years 17.8%. Majority of diseased were male 285 (81.9%). Most common lung pathology found was Edema and congestion in 93 cases (26.72%), chronic venous congestion in 92 cases (26.44%) pneumonia in 65 cases (18.68%) followed by Tuberculosis/Tuberculous pneumonia in 29 cases (8.3%).Conclusions: In our population, the present study reveals that infectious disease are still the most common cause of mortality, despite recent advances in diagnostic technology, the autopsy has remained an important complementary tool for identifying and understanding pathology of disease.

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Section: Discussionmentioning

confidence: 79%

Pattern of histopathological lesions in lung autopsy

Patel

Bhagat

et al. 2017

Int J Res Med Sci

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“…[ 11 ] Pratima et al . [ 12 ] and Chandani et al . [ 13 ] cases of emphysema were 6.5%, 8.9% and 4.3%.…”

Section: Discussionmentioning

confidence: 99%

Autopsy study of spectrum of lung lesions in Tertiary care hospital

Goswami

Khandkar

2021

Journal of Family Medicine and Primary Care

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Background: Inflammation, Infections, occupational diseases and neoplastic lesions are common in lungs. In Autopsy internal organs including lungs are studied to decide cause of death and figure out prevalence of various lung lesions. So, prophylactic prevention plan can be prepared for prevention of various lung lesions induced mortality and reducing need for invasive biopsy as well. Aim & objective: To find out frequency of various lung lesions in relation to age and sex and analyze histopathological spectrum of lung lesions. Material & Methods: Non interventional, record based cross sectional, retrospective autopsy study was done on 139 cases of lung autopsy samples at department of pathology of tertiary care hospital, Bhavnagar, Gujarat for 2 years on samples received from January 2016 to January 2018. Lungs were fixed in 10% formalin & processed. Paraffin wax embedding was done & sections stained with H&E stain. Gross and microscopic examination of samples done and diagnosis was done. All findings were recorded and tabulated. Conclusion: Pneumonia is most common observed pathological lung lesion in our study which suggest that infections of lungs are common cause for mortality. Therefore, we suggest effective implementation of measures to prevent hospital acquired pneumonia may reduce mortality. Smoking was associated in nearly 70% patients. Autopsy study of such lung lesions can provide vision to plan preventive strategy to reduce mortality due to lung pathology.

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“…In a smaller study from India, including 86 cases, the prevalence of lung pathology findings in autopsies was 65%. This is higher compared to our study, but the authors included congestion and edema caused by cardiac failure in their list of diagnoses [ 20 ]. Apart from that, the range of pathologies comprised mainly inflammatory diseases.…”

Section: Discussionmentioning

confidence: 63%

Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations—A Single Center Experience before COVID-19

et al. 2021

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Coronavirus disease 2019 (COVID-19) has shown the importance of postmortem investigation of deceased patients. For a correct interpretation of the pulmonary findings in this new era, it is, however, crucial to be familiar with pathologic pulmonary conditions observed in postmortem investigations in general. Adequate postmortem histopathological evaluation of the lungs may be affected by suboptimal gross work up, autolysis or poor fixation. Using a standardized preparation approach which consisted in instillation of 4% buffered formaldehyde through the large bronchi for proper fixation and preparing large frontal tissue sections of 1–2 cm thickness after at least 24 h fixation, we comprehensively analyzed postmortem pulmonary findings from consecutive adult autopsies of a two-year period before the occurrence of COVID-19 (2016–2017). In total, significant pathological findings were observed in 97/189 patients (51%), with 28 patients showing more than one pathologic condition. Acute pneumonia was diagnosed 33/128 times (26%), embolism 24 times (19%), primary pulmonary neoplasms 18 times (14%), organizing pneumonia and other fibrosing conditions 14 times (11%), pulmonary metastases 13 times (10%), diffuse alveolar damage 12 times (9%), severe emphysema 9 times (7%) and other pathologies, e.g., amyloidosis 5/128 times (4%). Pulmonary/cardiopulmonary disease was the cause of death in 60 patients (32%). Clinical and pathological diagnoses regarding lung findings correlated completely in 75 patients (40%). Autopsy led to confirmation of a clinically suspected pulmonary diagnosis in 57 patients (39%) and clarification of an unclear clinical lung finding in 16 patients (8%). Major discrepant findings regarding the lungs (N = 31.16%) comprised cases with clinical suspicions that could not be confirmed or new findings not diagnosed intra vitam. A significant proportion of acute pneumonias (N = 8; 24% of all cases with this diagnosis; p = 0.011) was not diagnosed clinically. We confirmed the frequent occurrence of pulmonary pathologies in autopsies, including inflammatory and neoplastic lesions as the most frequent pathological findings. Acute pneumonia was an important cause for discrepancy between clinical and postmortem diagnostics

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Prevalence of Lung Lesions at Autopsy: A Histopathological Study

Cited by 15 publications

References 5 publications

Pattern of histopathological lesions in lung autopsy

Pattern of histopathological lesions in lung autopsy

Autopsy study of spectrum of lung lesions in Tertiary care hospital

Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations—A Single Center Experience before COVID-19

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