Prevalence of major morbidities and outcome of all hospitalized neonates. A retrospective cohort study of Huai’an neonatal survivals

Xu, Yaling; Zhu, Xiaoqin; Wang, Hui; Pan, Zhaojun; Li, Xiaoqiong; Guo, Xiaojing; Yue, Hongni; Sun, Bo

doi:10.1080/14767058.2022.2054320

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Previous maternal diabetes and newborn outcomes investigations were confirmed and expanded by this research [20]. Method of delivery, stillbirth, APGAR scores, and infant mortality match existing data, supporting that diabetes pregnancies need specific treatment to improve mother and neonate health [27,28]. Diabetes pregnancies increase neonatal mortality and morbidity, emphasized the need for specialized prenatal and perinatal care.…”

Section: Discussionsupporting

confidence: 67%

Feto Maternal Outcome in Diabetic Mother and Its Association With Neonatal Mortality: A Study of Tertiary Hospital of Peshawar, KPK Pakistan

Hanif

2024

JPTCP

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Introduction:The aim of the current study was to investigate the association between feto maternal outcome in diabetic mothers and its association with neonatal mortality in tertiary care hospital, Peshawar, Pakistan. Methods: A retrospective cross-sectional research design was adopted in January 2024-June 2024. The population of the current study included all the mothers who were diagnosed with pre-existing diabetes who delivered at Hayatabad Medical Complex, Peshawar during the past 6 months. Data was collected from the medical records. A sample of 168 diabetic mothers, calculated through Cochran's formula, and their new newborns was collected through purposive sampling technique. Maternal Outcomes, including Mode of Delivery and Postpartum Hemorrhage (PPH), while Fetal Outcomes including Stillbirth, Meconium-Stained Liquor and Low APGAR Score was calculated. Demographics, descriptive, and Chi-square test was conducted for association between maternal diabetes and neonatal mortality rates based on maternal diabetes characteristics. Analyses was done through SPSS. Results: The results indicated that 35.1% had type 1 diabetes and 64.9% had type 2 diabetes, indicating a predominant presence of type 2 diabetes in the study sample. Majority of diabetic mothers (47.6%) underwent normal delivery, while 37.5% required cesarean section, and 14.9% had instrumental delivery. Similarly, a total of 8.9% of mothers sustained genital tract trauma during delivery, indicating potential complications associated with childbirth. 8.9% of newborns of diabetic mothers were stillborn, indicating a significant risk factor associated with maternal diabetes. A low APGAR score (<8/10) was observed in 23.8% of newborns, highlighting potential neonatal health challenges at birth. The neonatal mortality was 4.8%, indicating deaths among newborns within the first 28 days of life and there was a significant association between maternal outcomes and neonatal mortality (Chi-Square = 6.21, p = 0.013). Conclusion:According to the results of the current study, diabetes may have serious consequences for both mother and neonates therefore early diagnosis and treatment with dietary changes and use of oral hypoglycemic drugs or insulin are crucial. Pregnant women with pre-existing diabetes are more likely to have complications throughout their pregnancy,

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Section: Discussionsupporting

confidence: 67%

Feto Maternal Outcome in Diabetic Mother and Its Association With Neonatal Mortality: A Study of Tertiary Hospital of Peshawar, KPK Pakistan

Hanif

2024

JPTCP

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“…Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease in the neonatal period, especially in preterm infants ( Neu, 2020 ). According to the multicenter studies, the incidence rate of NEC in preterm infants is reported to be 3–12% ( Eaton, 2017 ; Meister et al, 2020 ; Cao et al, 2021 ) and the mortality is 9.4–17.6% ( D'Apremont et al, 2020 ; Cao et al, 2022 ; Xu et al, 2022 ) and can be much higher in those requiring surgeries ( Geng et al, 2018 ; D'Apremont et al, 2020 ). Moreover, among survivors, complications such as intestinal stricture, short bowel syndrome and delayed neurological development seriously affect their quality of life ( Frost et al, 2017 ; Berken and Chang, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Changes of gut microbiota and tricarboxylic acid metabolites may be helpful in early diagnosis of necrotizing enterocolitis: A pilot study

Liu

et al. 2023

Front. Microbiol.

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PurposeWe aimed to explore the value of gut microbiota and tricarboxylic acid (TCA) metabolites in early diagnosis of necrotizing enterocolitis (NEC) among infants with abdominal manifestations.MethodsThirty-two preterm infants with abdominal manifestations at gestational age ≤ 34 weeks were included in the study and were divided into non-NEC (n = 16) and NEC (n = 16) groups. Faecal samples were collected when the infants were enrolled. The gut microbiota was analysed with high-throughput sequencing, and TCA metabolites were measured with multiple reaction monitoring (MRM) targeted metabolomics. Receiver operating characteristic (ROC) curves were generated to explore the predictive value of the obtained data.ResultsThere was no significant difference in alpha diversity or beta diversity between the two groups (p > 0.05). At the phylum level, Proteobacteria increased, and Actinomycetota decreased in the NEC group (p < 0.05). At the genus level, Bifidobacterium and Lactobacillaceae decreased significantly, and at the species level, unclassified Staphylococcus, Lactobacillaceae and Bifidobacterium animalis subsp. lactis decreased in the NEC group (p < 0.05). Further Linear discriminant analysis effect sizes (LEfSe) analysis showed that the change in Proteobacteria at the phylum level and Lactobacillaceae and Bifidobacterium at the genus level scored higher than 4. The concentrations of succinate, L-malic acid and oxaloacetate in the NEC group significantly increased (p < 0.05), and the areas under the ROC curve for these metabolites were 0.6641, 0.7617, and 0.7344, respectively.ConclusionDecreased unclassified Staphylococcus, Lactobacillaceae and Bifidobacterium animalis subsp. lactis at the species level as well as the increase in the contents of some TCA metabolites, including succinate, L-malic acid and oxaloacetate, have potential value for the early diagnosis of NEC.

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Efficacy of perinatal pharmacotherapeutic actions for survival of very preterm newborn rabbits at 26-day gestation

Chen

Guo

et al. 2023

Journal of Applied Physiology

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Background: Investigation of pathophysiology of lung impairment and protection in very preterm neonates at birth require adequate experimental models. This study aimed to elucidate efficacy and mechanism of perinatal pharmacotherapeutic action in postnatal survival of very preterm rabbits. Methods: Pregnant New Zealand White rabbits on 25-day gestation (term 31 days) were given dexamethasone (D), or sham injection as control (C), and cesarean delivered 24 hours later on day 26. Newborns were anesthetized, intratracheally intubated, randomly received either saline or porcine surfactant (S), allocated to four groups (C, S, D, DS), and ventilated with low tidal volume. Under the identical protocol, another four groups were added with nitric oxide (N) inhalation (CN, SN, DN, DSN). Survival length, lung mechanics, histopathology and pathobiology of lung tissue were measured for benefits and injury patterns. Results: DSN had the longest median survival time (ST50, 10.3 h) while C had the shortest (3.5 h), with remaining groups in-between. The survival was mainly benefited by S, when additive effects with D and/or N were discernible, by improved lung mechanics and alveolar aeration, ameliorated lung injury severity and pneumothorax, and augmented lung phospholipid pools, with DSN being the most optimal. Variable mRNA expression profiles of alveolar epithelia-associated cytokines and inflammatory mediators further characterized injury and response patterns as phenotyping conditioned in pharmacotherapeutic actions. Conclusion: The combined regimens of perinatal medications achieved remarkable survival in very preterm rabbits with lung protective ventilation strategy, offering a unique model in investigation of very preterm birth-associated respiratory physiology and morbidities.

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Prevalence of major morbidities and outcome of all hospitalized neonates. A retrospective cohort study of Huai’an neonatal survivals

Cited by 4 publications

References 25 publications

Feto Maternal Outcome in Diabetic Mother and Its Association With Neonatal Mortality: A Study of Tertiary Hospital of Peshawar, KPK Pakistan

Feto Maternal Outcome in Diabetic Mother and Its Association With Neonatal Mortality: A Study of Tertiary Hospital of Peshawar, KPK Pakistan

Changes of gut microbiota and tricarboxylic acid metabolites may be helpful in early diagnosis of necrotizing enterocolitis: A pilot study

Efficacy of perinatal pharmacotherapeutic actions for survival of very preterm newborn rabbits at 26-day gestation

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