Prevalence of malnutrition in adult patients previously treated with allogeneic hematopoietic stem-cell transplantation

Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients

“…In the present study, mean body weight decreased during the first year post-HSCT, in line with several other studies [3][4][5][6]. Moreover, mean percentage of total body water increased until 3 months and remained high compared to baseline during the 1-year follow-up.…”

“…Additionally, glucocorticoid therapy is known to have an effect on weight gain and body composition, in particular muscle atrophy, central accumulation of fat mass and increased extracellular fluid volume [29,30]. Corroborating this, one study found an association between decrease in indirect measurement of fat-free mass, and aGVHD, and glucocorticoid therapy [6]. We interpreted an early increase in FFMI and weight gain as fluid retention.…”

“…Upon admission for allogeneic hematopoietic stem-cell transplantation (allo-HSCT) many patients have lost body weight and some may even be malnourished [1,2]. Weight loss often increases in the peritransplant period [3][4][5][6]. A study found increased risk of nonrelapse mortality (NRM) and inferior overall survival in patients with >10% weight loss compared with weight loss <10% [3], while an association between weight loss and survival was not found in another study [5].…”

Supplement Article

“…Establishing the rate of acceptance of a nasogastric feeding tube in allogeneic transplant patients within a national centre A. Dean, C. Leslie* National Stem Cell Transplant Unit, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom Most patients are well nourished prior to allogeneic stem cell transplant with only 10-15% being malnourished (Brotelle et al 2017). Haematopoietic stem cell transplant (HSCT) can have a significant impact on nutritional intake due to mucositis, increased rates of infection, immunosuppressive drugs and nausea/vomiting.…”

Body composition assessment in hematopoietic stem cell transplantation

“… 2 Low arm muscle area measured pre-HSCT has been associated with 180-day mortality post-transplant. 5 Other studies have evaluated upper-limb muscle strength, air-displacement plethysmorgraphy and bioelectrical impedance analysis (BIA) with standardized phase angle in long-term follow-up of allo-HSCT recipients 6 , 7 , 8 ; however, such studies require further validation and standardization in larger numbers of patients in disease- and age-specific settings.…”