Prevalence of maternal alloantibodies in a large teaching hospital and their impact on outcomes of fetuses/neonates

Ainley, Louise; Jardim, José Roberto; Tan, Joachim; Beski, S.; RiosLeal, E. M.; Allard, Shubha; Green, L.

doi:10.1111/tme.12399

Cited by 6 publications

(5 citation statements)

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“…Severe HDFN was associated with maternal anti‐K and anti‐c and to a lesser extent with the other antibodies. Other reports also found that most maternal alloantibodies were non‐D Rh antibodies and anti‐K 10–14,19,20 . In our study, the most prevalent, clinically significant non‐D maternal antibodies, found singly or in combination with other antibodies, are consistent with these reports: anti‐E 204 of 900 (22.6%), anti‐K 145 of 900 (16.1%), and anti‐c 98 of 900 (10.9%; Figure 1).…”

Section: Discussionsupporting

confidence: 91%

“…This is the first large report on RBC alloantibodies frequency and composition in the Israeli population. The findings in this study are comparable to previous large studies screening for RBC alloantibodies in pregnant women published in the literature from Iceland, 10 Croatia, 11 and England, 12,13 in which the rate of alloimmunization among pregnant women ranged from 0.71% to 1.32%. A lower rate of alloimmunization (0.4%) was reported from Sweden.…”

Section: Discussionsupporting

confidence: 90%

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Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study

2020

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Background Hemolytic disease of the fetus and newborn (HDFN) is a severe form of anemia caused by maternal antibodies against fetal red blood cells (RBC) that can cause intrauterine and perinatal morbidity and mortality. The prevalence and specificities of alloantibodies among Israeli pregnant women and clinical outcomes for their fetuses and newborns are unknown. Study Design and Methods: A retrospective study of women who gave birth between January 1, 2011, and December 31, 2011, was performed. Data were obtained for obstetric admissions from 16 of 27 hospitals, which included results of maternal ABO, D, antibody screens, antibody identification, and requirements for intrauterine or newborn exchange transfusions. Results: Data on 90 948 women representing 70% of all births during 2011 were analyzed. Antibody screen was positive in 5245 (5.8%) women. Alloantibodies, excluding anti-D titer (<16) were identified in 900 (1.0%) women. Of 191 D-women, 75 (39.3%) had anti-D titer of 16 or greater. Other common Abbreviation: HDFN, hemolytic disease of the fetus and newborn

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study

2020

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“…8 This study aimed to obtain information on the prevalence of alloimmunization and how it is distributed within the different Rh blood phenotypes among pregnant women, to provide a baseline for policy information and future planning towards pregnancy management, as a way of preventing hemolytic disease of the newborn. [9][10][11]…”

Section: Introductionmentioning

confidence: 99%

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Mbalibulha¹,

Natukunda²,

Okwi³

et al. 2022

JBM

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Introduction Maternal red cell alloimmunization to Rh antigen in pregnant women occurs when the immune system is sensitized by foreign red blood cell surface antigens, in this case fetal red blood cells, inducing an immune response. Various antigens of blood group systems may cause alloimmunization, especially the Rh, Kel, Fy, JK, and MNS systems. This study aimed to determine alloimmunization to the different frequencies of Rh antigen among pregnant women in South Western Uganda. Methods A total of 1369 pregnant women consented and were recruited into a cross-sectional study during their regular antenatal visits during the period August 2020 to July 2021. Samples (4 mL) of anticoagulated and coagulated blood were obtained, and Rh blood grouping including Rh antigen and the indirect antiglobulin test (IAT) was carried out using the agglutination technology of the LISS ID-Card technique in the Ortho Biovue ID-Micro Typing System. Results Out of 1369 participants recruited to the study, 78 (5.7%) were D − , 1291 were D + , and 134 (9.8%) had alloantibodies. Among those with alloantibodies, 115 (85.8%) were D + and 19 (14.2%) D − . The percentage alloimmunization according to the Rh antigens was highest in e (9.72%), c (2.48%), C (2.34%) and E (0.94%) antigens. With the ABO system, alloimmunization was highest in blood group B (10.7%), followed by A (10.6%), O (9.2%) and then AB (7.1%). Alloimmunization was more prevalent in D − (24%) than in D + participants (8.9%). Rhesus antigen e was the most prevalent antigen (99.8%), followed by c. The alloimmunization rate of 9.8% among these participants is high, and appears in both D + and D − women. The other Rhesus antigens are seen to cause alloimmunization, with antigen e causing the highest prevalence. In conclusion, there is a need to identify antibodies and study the outcome for clinical significance, especially in D + women, to facilitate proper pregnancy management.

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“…e role of the college teaching management system in improving teaching quality and achieving teaching goals cannot be replaced by any other link [7,8]. Furthermore, the theory of objective management shows that when using an incentive method to define goals, many aspects such as time, society, and needs must be taken into account.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Impact of the MOOC Learning Platform on the Comprehensive Development of English Teachers at College Level under “Double First-Rate” by Utilization of the SWOT Analysis in Hunan Province, China

2022

Journal of Advanced Transportation

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This research is to investigate the impact of massive open online course (MOOC) learning platforms on teacher development, promote the development and innovation of online learning models under the “Double First-Rate,” and especially expand the application of the MOOC platforms combining language learning with professional development paths. The MOOC online learning platform has a problem of a high abandonment rate. This paper first proposes a MOOC learning recommendation algorithm based on the learning sequence and similarity distance analysis as well as evaluates its accuracy. Then, the reliability test and the MOOC learning recommendation algorithm are used to evaluate the quality evaluation system of English teaching in the MOOC utilizing the structural equation model. Finally, the strengths, weaknesses, opportunities, and threats (SWOT) are determined to analyze the impact of the MOOC regarding the English teaching platform on teachers' comprehensive development. The results show that the MOOC platform-based learning recommendation algorithm has higher recommendation accuracy and efficiency, improving the learning effect with the utilization of the MOOC. Also, it can effectively reduce the abandonment rate and has a positive effect of resolving the interaction problem pertinent to characteristic differences and sequences in the learning recommendation. The quality evaluation system of online English teaching in the MOOC has higher reliability and convergent validity, which shows better stability and consistency in all dimensions. If teachers can actively learn from the resources of the MOOC platform, then they continuously update teaching concepts, improve online teaching, give full play to their language advantages, accurately locate student needs, and develop unique courses. Therefore, it will promote the overall development of their careers and improve innovation.

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Prevalence of maternal alloantibodies in a large teaching hospital and their impact on outcomes of fetuses/neonates

Cited by 6 publications

References 6 publications

Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study

Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study

Alloimmunization to Rh Antigen (D, C, E, C, E) Among Pregnant Women Attending Antenatal Care in South Western Uganda

Assessing the Impact of the MOOC Learning Platform on the Comprehensive Development of English Teachers at College Level under “Double First-Rate” by Utilization of the SWOT Analysis in Hunan Province, China

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