Prevalence of maxillary lateral incisor agenesis and associated skeletal characteristics in an orthodontic patient population

Bassiouny, Dalia S; Afify, Ahmed R.; Baeshen, Hosam Ali; Birkhed, Dowen; Zawawi, Khalid H.

doi:10.1080/00016357.2016.1193625

Cited by 24 publications

(29 citation statements)

References 29 publications

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“…Some previous studies have reported an association between TA and craniofacial morphological patterns [16][17][18][19][20][21][22][23], including retrognathic maxilla [18], class III skeletal malocclusion [18,22], and concave profile [21]. Additionally, our recent study demonstrated that TAassociated GLI2 and GLI3 genes might play a role in the development of skeletal malocclusions [24].…”

Section: Introductionsupporting

confidence: 55%

Association between craniofacial morphological patterns and tooth agenesis-related genes

et al. 2020

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Background: The aim of the present study was to assess if genetic polymorphisms in tooth agenesis (TA)-related genes are associated with craniofacial morphological patterns. Methods: This cross-sectional, multi-center, genetic study evaluated 594 orthodontic Brazilians patients. The presence or absence of TA was determined by analysis of panoramic radiography. The patients were classified according to their skeletal malocclusion and facial growth pattern by means of digital cephalometric analysis. Genomic DNA was extracted from squamous epithelial cells of buccal mucosa and genetic polymorphisms in MSX1 (rs1042484), PAX9 (rs8004560), TGF-α (rs2902345), FGF3 (rs1893047), FGF10 (rs900379), and FGF13 (rs12838463, rs5931572, and rs5974804) were genotyped by polymerase chain reaction using TaqMan chemistry and end-point analysis. Results: Genotypes (p = 0.038) and allele (p = 0.037) distributions for the FGF3 rs1893047 were significantly different according to the skeletal malocclusion. Carrying at least one G allele increased in more than two times the chance of presenting skeletal class III malocclusion (OR = 2.21, CI 95% = 1.14-4.32; p = 0.017). There was no association between another skeletal craniofacial pattern and some polymorphism assessed in the present study. Conclusion: Our results suggest that the genetic polymorphism rs1893047 in FGF3 might contribute to variations in the craniofacial sagittal pattern.

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Section: Introductionsupporting

confidence: 55%

Association between craniofacial morphological patterns and tooth agenesis-related genes

et al. 2020

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“…However, MLIA did not cor relate with the change in the inclination of the palatal plane relative to the Frankfurt plane. A study by Bas siouny et al [35] showed that patients with congeni tal lack of maxillary lateral incisors have a significant tendency to skeletal class III. The researchers attribute these results to the occurrence of maxillary hypoplasia (retrognathia) in these patients.…”

Section: Analysis Of the Obtained Resultsmentioning

confidence: 99%

Co-occurrence of agenesis of the maxillary lateral incisors with other dental anomalies – a systematic review of the literature

Parchańska-Kowalik¹,

Stós²,

Loster³

2018

jos

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Introduction: Hypodontia of the maxillary lateral incisors is a developmental disorder whose genetic basis has been documented scientifically. Coexistence of hypodontia and other dental anomalies may indicate the occur rence of mutations within a given gene, the expression of which may be manifested in various phenotypic com binations. Objectives: The aim of the study was to determine the frequency of cooccurrence of agenesis of the maxillary lateral incisors with other dental anomalies and skeletal disorders, based on a systematic review of the literature. Material and methods: An online database was searched using PubMed and Science Direct by entering the fol lowing keywords: maxillary lateral incisor agenesis and dental anomalies. Results: A total of 1168 results were obtained. Eighteen articles from 19712016 that met the inclusion criteria were qualified for the analysis. Hypodontia of the maxillary lateral incisors is very often accompanied by other dental or skeletal disorders. These are most often: agenesis of another permanent tooth, ectopic maxillary canine eruption, distoangulation of mandibular second premolars, reduction of the overall size of the teeth, the occur rence of a pegshaped or microdontic maxillary lateral incisor, the rectangular shape of crowns of the maxil lary central incisors, taurodontism. Skeletal class III is much more common than in the general population and the vertical relationship is also reduced. The most frequent was distal relation on the molars and canines. Conclusions: Based on information obtained from medical databases and library resources, it can be concluded that hypodontia of the maxillary lateral incisors is a condition predisposing to the cooccurrence of other disor ders: size, structure, position and quantity of remaining permanent teeth. When planning orthodontic treatment, attention should also be paid to the frequent prevalence of skeletal III in these patients and to the reduced vertical relationship.

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“…Patients with an Class I malocclusion with mandibular crowding requiring extractions, and those with a Class II malocclusion with a mildly convex profile may be successfully treated with space closure, but those whose profiles are moderately to severely convex, with a retrusive mandible, and a deficient chin prominence may require treatment that also addresses the facial profile . An orthodontic population examined by Bassiouny et al, demonstrated a significant tendency toward a skeletal Class III relationship in patients with missing laterals and space closure may exacerbate this discrepancy. Restoration with a RBFDP or an implant may be a better option for these patients.…”

Section: Canine Substitutionmentioning

confidence: 99%

The treatment dilemma of missing maxillary lateral incisors‐Part I: Canine substitution and resin‐bonded fixed dental prostheses

Priest

2019

J Esthet Restor Dent

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Objective Clinicians are faced with three common treatment options for the high frequency of missing or lost maxillary lateral incisors; canine substitution, a resin‐bonded fixed dental prosthesis (RBFDP), or a dental implant. A review of current data and guidelines for treatment provide new insight into making the most appropriate selection. Overview The incidence of maxillary incisor agenesis and loss is prevalent. Both canine substitution and RBFDPs exhibit esthetic and functional advantages and disadvantages. Conclusions Most missing lateral incisors are detected at an early age as a result of congenital absence; therefore, proper treatment of these young patients is essential. Both canine substitution and RBFDPs can provide long‐term success and esthetics when carefully executed. The decision should be based on the patient's expectations, their clinical presentation, cost, and the team's ability to provide the best long‐term esthetic and functional prognosis for a specific patient. Clinical significance Patients regularly present for treatment of missing and lost maxillary lateral incisors. The functional and esthetic aspects of canine substitution and a RBFDP should be clearly understood relative to the clinical parameters of each patient prior to treatment.

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Prevalence of maxillary lateral incisor agenesis and associated skeletal characteristics in an orthodontic patient population

Abstract: Patients with maxillary lateral incisor agenesis showed a significant tendency for skeletal Class III compared with the Class I control. This could be attributed to maxillary hypoplasia/retrognathia.

Cited by 24 publications

References 29 publications

Association between craniofacial morphological patterns and tooth agenesis-related genes

Association between craniofacial morphological patterns and tooth agenesis-related genes

Co-occurrence of agenesis of the maxillary lateral incisors with other dental anomalies – a systematic review of the literature

The treatment dilemma of missing maxillary lateral incisors‐Part I: Canine substitution and resin‐bonded fixed dental prostheses

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