Prevalence of molar-incisor-hypomineralisation (MIH) among 6–12-year-old children in Central Hesse (Germany)

Amend, Stefanie; Nossol, C; Bausback-Schomakers, S; Wleklinski, Carl; Scheibelhut, Christine; Pons-Kühnemann, Jörn; Frankenberger, Roland; Krämer, Norbert

doi:10.1007/s00784-020-03519-7

Cited by 23 publications

(22 citation statements)

References 42 publications

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“…This finding might be due to the possibility of carious lesion masking MIH among older children. 5 , 23 , 24 In agreement with the previous studies, 14 , 21 the present study showed a slightly higher prevalence of MIH among girls than boys; however, the difference was not statistically significant.…”

Section: Discussionsupporting

confidence: 92%

“…The present study result showed that upper permanent first molars were the most frequently affected teeth, and demarcated opacity was the most frequent type of MIH as reported by previous studies. 14 , 16 , 20 , 21 , 24 , 25 The prevalence of posteruptive enamel breakdown, atypical restoration, and tooth loss were slightly higher compared to the previous studies. 6 , 9 This may be due to the inclusion of older age children in the present study.…”

Section: Discussioncontrasting

confidence: 51%

“…However, the global prevalence of MIH among normal children varied from 2.4% to 40.2%, depending upon the population studied, age group involved, and diagnostic criteria for MIH. 6 – 11 , 19 – 24 In the present study, children were aged from 6–16 years, and the prevalence of MIH was slightly higher among 6-11-year-old CSHCN compared to 12–16 years. This finding might be due to the possibility of carious lesion masking MIH among older children.…”

Section: Discussionmentioning

confidence: 51%

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Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

et al. 2021

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BACKGROUND: Molar incisor hypomineralization (MIH) is a frequently encountered oral condition that varies from mild opacities to posteruptive enamel breakdown. No previous published studies have investigated the frequency of MIH and associated risk factors among children with special health care needs (CSHCN) to our awareness. OBJECTIVES: Assess the frequency of MIH and associated risk factors among CSHCN. DESIGN: Cross-sectional. SETTING: Schools in provincial city of Saudi Arabia. PATIENTS AND METHODS: The study was conducted among 400 (180 boys and 220 girls) special needs children. Diagnosis of MIH was according to the European Academy of Paediatric Dentistry criteria. MAIN OUTCOME MEASURE: Result of logistic regression analysis that assessed the association between MIH prevalence and associated prenatal, perinatal, and postnatal factors. SAMPLE SIZE: 400 (180 boys and 220 girls) special needs children. RESULTS: Among 400 CSHCN, 98 (24.5%) presented with MIH. Children with multiple disabilities had a 3.89 times greater risk of MIH (95% CI: 1.91–6.19, P =.002). Children with positive prenatal factors had an adjusted odds ratio (aOR) of 2.31 times for MIH (95% CI: 1.22–4.73, P =.012). Children with a childhood infection history had an aOR of 2.43 times for MIH (95% CI: 1.31–5.85, P =.014). Children with a breastfeeding history >18 months had an aOR of 3.73 for MIH (95% CI: 1.62–8.60, P =.002). Permanent maxillary first molars were the most frequently affected teeth, and demarcated opacity was the most frequent MIH type. CONCLUSION: MIH should be recognized as one of the prevalent oral health problems among CSHCN to prevent tooth mortality. LIMITATIONS: A cross-sectional study cannot establish a causal relationship. CONFLICTS OF INTEREST: None.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 51%

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Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

et al. 2021

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“…The evidence that MIH frequency varies across the world [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] is supported by the results found in the present study. The association found in the Turkish population was different from the results obtained in the cohorts from Brazil, which indeed indicates that genetic factors contributing to the MIH phenotype may vary depending on geographic origin.…”

Section: Plos Onesupporting

confidence: 82%

“…These asymmetrical lesions affect the first permanent molars, usually with the permanent incisors [4], and more recently MIH has been reported to affect canines too [5]. Prevalence of MIH varies but has been consistently reported to range between 1% and 35% in all parts of the world, with most reported frequencies around 12% [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Gene-environment interaction in molar-incisor hypomineralization

et al. 2021

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Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.

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Effects of different remineralization agents on MIH defects: a randomized clinical study

2021

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Prevalence of molar-incisor-hypomineralisation (MIH) among 6–12-year-old children in Central Hesse (Germany)

Cited by 23 publications

References 42 publications

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

Gene-environment interaction in molar-incisor hypomineralization

Effects of different remineralization agents on MIH defects: a randomized clinical study

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