Prevalence of Non-alcoholic Fatty Liver Disease and Steatohepatitis Risk Factors in Patients Undergoing Bariatric Surgery

Morita, Shinhiti; Neto, Dalisio de Santi; Morita, Flávio; Morita, Nina Kimie; Lobo, Suzana Margareth

doi:10.1007/s11695-015-1696-5

Cited by 38 publications

(26 citation statements)

References 43 publications

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“…Morita et al studied the prevalence of steatohepatitis and its predictive markers in patients with obesity undergoing bariatric surgery. They concluded that age, waist circumference, serum ALT and TG levels were the efficient non-invasive predictive markers to diagnose and manage steatohepatitis in patients with morbid obesity (33). There are various predicting or alarming factors for NASH in accordance to several studies.…”

Section: Discussionmentioning

confidence: 90%

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

et al. 2017

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Background and Objectives: Obesity is one of the most health-threatening phenomena. It is estimated that over 1 billion adults have overweight or obesity. The current study aimed at presenting a detailed account of the findings that attempted to predict the severity of fatty liver disease and its sequelae, including non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, by correlating biopsy results with liver function tests and various metabolic markers of laboratory results in patients with morbid obesity.

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Section: Discussionmentioning

confidence: 90%

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

et al. 2017

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“…10 However, Results from different studies show that the prevalence of NAFLD varies between 16.7% and 96% in morbidly obese patients subjected to bariatric surgery. [10][11][12][13][14][15][16][17][18][19][20][21][22] The wide range of NAFLD prevalence depends on the biochemical criteria and the method sensitivity used to detect NAFLD. 8,23 Furthermore, NASH, as a progressive manifestation of NAFLD, occurs in 7.3% to 98% of such patients.…”

Section: Prevalence Of Nafld and Nash In Bariatric Candidatesmentioning

confidence: 99%

Role of bariatric surgery in treatment of non-alcoholic fatty liver disease

Kermansaravi

Ebrahimian

Delbari

et al. 2017

J. contemp. med. sci.

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The prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing due to increasing of morbid obesity prevalence worldwide. It has been demonstrated that weight loss is the corner stone of NAFLD/NASH treatment. Various options are available for weight loss in obese patients, such as life style modification, pharmacotherapy, endoscopic interventions and bariatric/metabolic surgery. Performing bariatric/meta bolic surgery only for NAFLD/NASH treatment is on debate, but it has been proven that bar iatric surgery is the most durable and effective treatment for weight loss and obesity-related comorbidities.

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“…It has been found that the prevalence of NAFLD was 84%, and noninvasive markers include the age, waist circumference, serum ALT activity, and serum triglyceride level are efficient for the diagnosis and management of NAFLD in morbidly obese patients [26].…”

Section: Bariatric Surgery the Liver And Insulin Insensitivitymentioning

confidence: 99%

How Does Bariatric Surgery Improve Type II Diabetes? The Neglected Importance of the Liver in Clearing Glucose and Insulin from the Portal Blood

Alwahsh¹,

Ramadori²

2015

J Obes Weight Loss Ther

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The pandemic of obesity due to food "addiction" has led to a dramatic increase in rates of Type II Diabetes Mellitus (T2DM). T2DM is characterized by increased glucose and insulin (but not of the C-peptide) serum levels. Increase of insulin serum level without increase of insulin synthesis is supposed to be due to insulin resistance. Reduction of body weight (BW) through reduction of calories uptake is the most effective measure to treat T2DM and metabolic syndrome in obese patients.Appetite suppressant drugs which potentially reduce BW have several side effects, and as "lifestyle modifiers" are not approved of as potential antidiabetic drugs. In addition to the treatment of extreme (BMI ≥ 40) obesity, surgeons have expanded the offer of bariatric surgery as therapeutic option for diabetic, "non-morbid" (BMI ≤ 35) obesity. As a "collateral effect" of this surgical intervention, acute and long-term improvement of T2DM has been observed. Although several hypotheses to explain this improvement have been reported, the exact mechanism underlying the reduced hyperglycemia and hyperinsulinemia immediately after surgery is unclear. Though long-term effects of the different operations have not yet been studied thoroughly.Besides weight-loss, bariatric surgery may also reduce lipid accumulation in the liver. Reverse of the hepatic lipid deposition may improve clearance of glucose and insulin from the liver and consequently lead to reduction their concentrations in the peripheral blood. This mechanism has not, however, been considered when effects of bariatric surgery on glucose metabolism have been reported. In fact, a few reports on limited patients number already published have given information about changes of liver size and/or liver lipid content at different time points postoperation. Future prospective studies should focus on the changes in glucose and lipid metabolism induced in the liver by the various types of surgical interventions.

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Prevalence of Non-alcoholic Fatty Liver Disease and Steatohepatitis Risk Factors in Patients Undergoing Bariatric Surgery

Abstract: Age, waist circumference, serum ALT levels, and serum triglyceride levels are efficient and non-invasive predictive markers for the diagnosis and management of steatohepatitis in morbidly obese patients.

Cited by 38 publications

References 43 publications

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

Role of bariatric surgery in treatment of non-alcoholic fatty liver disease

How Does Bariatric Surgery Improve Type II Diabetes? The Neglected Importance of the Liver in Clearing Glucose and Insulin from the Portal Blood

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