Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients

Martinez‐Martín, Pablo; Schapira, Anthony H.V.; Stocchi, Fabrizio; Sethi, Kapil D.; Odin, Per; Macphee, G. J. A.; Brown, Richard G.; Naidu, Y.; Clayton, Lisa; Abe, Kazuo; Tsuboi, Yoshio; MacMahon, Dough; Barone, Paolo; Rabey, Martin; Bonuccelli, Ubaldo; Forbes, Alison; Breen, Kieran C.; Tluk, S.; Olanow, C. Warren; Thomas, Sue; Rye, David B.; Hand, Annette; Williams, Adrian J.; Ondo, William G.; Chaudhuri, K. Ray

doi:10.1002/mds.21586

Cited by 484 publications

(359 citation statements)

References 14 publications

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“…In our study, a negative association was found between H&Y staging and MMSE while a positive association was found between Blessed test. 18 . Clinical presence and severity of autonomous involvement in PD is assessed effectively and correctly by using SCOPA-AUT questionnaire 8 .…”

Section: Resultsmentioning

confidence: 99%

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Aygün¹,

Akpınar²,

Yön³

et al. 2017

Dicle Tıp Dergisi

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Objective: Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. PD also involves nonmotor manifestations such as autonomic failure, cognitive disorders, and sleep disorders. These clinical characteristics are not identical in severity, frequency, and onset time in all PD patients. We assessed whether there is a negative effect on cognition of clinical autonomic dysfunction in PD patients.Results: Mean age was 66,5±11.2 years. There was no correlation between cognitive test scores and SCOPA-OUT scores (p>0.05). However, H-Y scores were negatively correlated with the DSTf, DSTr, FAB, and MMSE scores (p50.005, r:-0.451; p50.025, r: -0.367; p50.040, r: -0.340; p50.044, r5-0.333, respectively). Training and Education Hospital, Neurology clinic, Samsun, Turkey e-mail: dr_ckakpinar@hotmail.com Original Article/Özgün Araştırma Conclusions: According to our results, clinical autonomic dysfunction did not seem to have an effect on cognition. In addition, severity of cognitive dysfunction showed a strong negative correlation with the stage of disease.

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Section: Resultsmentioning

confidence: 99%

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Aygün¹,

Akpınar²,

Yön³

et al. 2017

Dicle Tıp Dergisi

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“…Generally, autonomic dysfunction prese ts i the latter stages of Parki so 's disease [12] but it can occur early and even before the hallmark motor dysfunction presents [13]. The proposed mechanisms of cardiovascular autonomic dysfunction in Parki so 's disease generally involve lewy body accumulation and cell loss in various key areas of the autonomic nervous system, such as, autonomic regulatory areas including the hypothalamus, medulla, locus coeruleus and raphe, pre-ganglionic parasympathetic and sympathetic regions including the dorsal vagal motor nuclei of the glossopharyngeal and vagal nerves, autonomic and sympathetic ganglia, as well as post-ganglionic sympathetic denervation [1] that ultimately affect control of blood pressure through baroreflex impairment and loss of sympathetic innervation.…”

Section: Discussionmentioning

confidence: 99%

Exercise hemodynamics in Parkinson's disease and autonomic dysfunction

Low

Vichayanrat

Iodice

2014

Parkinsonism & Related Disorders

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ArticleLJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. ResultsGroup mean systolic blood pressure (SBP) fell during pre-exercise standing (-39±29 mmHg, P<0.001, 17 patients had orthostatic hypotension (OH)), while heart rate (HR) increased (+13±7 beats.min-1, P<0.001). SBP (P<0.001) increased during exercise with a wide variation in responses. SBP increased in 13 patients (INC; +30±14 mmHg) and either did not change or decreased in 10 patients (DEC -12±11 mmHg, P<0.001 vs INC). The increase in HR was not different between sub-groups (30±12 vs 25±10 beats.min-1, INC vs. DEC, P=0.29). The size of the pre-exercise stand SBP reduction was greater in DEC vs INC (-64±23 (10 out of 10 had OH) vs -19±16 mmHg (7 out of 13 had OH), respectively, P<0.001). The HR elevation was not different between sub-groups (13±8 vs 13±4 beats.min-1, DEC vs INC, P=0.94). Post-exercise SBP/DBP were lower for both sub-groups compared to pre-exercise and the standing SBP reduction post-exercise was not greater relative to pre-exercise in either sub-group. ConclusionExercise-induced hypotension can occur in Parkinson's disease patients with autonomic failure with the magnitude of the exercise response being related to the severity of autonomic dysfunction. Exercise does not appear to worsen OH in this sample of Parkinson's patients.

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“…Several investigations have shown that about 50% of PD patients have insomnia complaints [16,17]. Both motor and non-motor symptoms may be responsible for the insomnia.…”

Section: Sleep Disordersmentioning

confidence: 99%

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Wang

et al. 2016

Neurosci. Bull.

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Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

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Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients

Cited by 484 publications

References 14 publications

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Exercise hemodynamics in Parkinson's disease and autonomic dysfunction

A New Perspective for Parkinson’s Disease: Circadian Rhythm

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