The aim of the study was to assess the effect of metformin plus lifestyle modification on procoagulant and proinflammatory state
associated with metabolic syndrome in postmenopausal women. Materials and methods: The 12-month prospective, open, randomized
study included 58 postmenopausal women (age 55 [53; 56]; postmenopause 5 [4; 8] years) with metabolic syndrome (IDF, 2005).
Participants were randomized into two groups receiving either metformin (1 g per day) plus lifestyle modification (n=29), or lifestyle
modification alone (control group) (n=29). Blood tests were performed before and after the treatment period to evaluate parameters
of coagulant and anticoagulant blood systems: prothrombin index, activated partial tromboplastin time (APTT), thrombin time, activities
of factors VII (FVII),VIII (FVIII), von Willebrand factor (vWF), antithrombin III, plasminogen activator inhibitor-1 (PAI-1),
tissue-type plasminogen activator (t-PA) and screening test for the protein C pathway. Also we assessed fibrinogen, C-reactive protein
(CRP) and adiponectin concentrations. Results: After one year of treatment in metformin group CRP level decreased significantly
from 4,98 [2,72; 11,95] to 2,56 [1,92; 6,76] mg/l (р