Prevalence of obstructive sleep apnea in children with sickle cell disease at a tertiary hospital in Saudi Arabia

Alotaibi, Tahani; Alqwaiee, Mansour M; Faraidi, Huda; Batniji, Fatima Al; Alotaibi, Faisal; Alharbi‎, Abdulrahman

doi:10.15537/smj.2017.6.19492

Cited by 19 publications

(20 citation statements)

References 20 publications

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“…A total of 7 studies reported the prevalence of sleep-disordered breathing in children and adults with SCD (total n 5 489), which ranged from 42% in children to 46% in adults. [72][73][74][75][76][77][78] Using a higher apnea-hypopnea index cutoff in children with SCD resulted in a lower prevalence. In 2 studies that reported cardiovascular outcomes (total n 5 115), sleep-disordered breathing was associated with a higher mean systolic blood pressure and evidence for impaired left-ventricular diastolic dysfunction, and lower nocturnal oxygen saturation was associated with a shorter time to first cerebrovascular event.…”

Section: Recommendationmentioning

confidence: 99%

American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease

et al. 2019

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Background: Prevention and management of end-organ disease represent major challenges facing providers of children and adults with sickle cell disease (SCD). Uncertainty and variability in the screening, diagnosis, and management of cardiopulmonary and renal complications in SCD lead to varying outcomes for affected individuals. Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about screening, diagnosis, and management of cardiopulmonary and renal complications of SCD. Methods: ASH formed a multidisciplinary guideline panel that included 2 patient representatives and was balanced to minimize potential bias from conflicts of interest. The Mayo Evidence-Based Practice Research Program supported the guideline development process, including performing systematic evidence reviews up to September 2017. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including GRADE evidence-to-decision frameworks, to assess evidence and make recommendations, which were subject to public comment. Results: The panel agreed on 10 recommendations for screening, diagnosis, and management of cardiopulmonary and renal complications of SCD. Recommendations related to anticoagulation duration for adults with SCD and venous thromboembolism were also developed. Conclusions: Most recommendations were conditional due to a paucity of direct, high-quality evidence for outcomes of interest. Future research was identified, including the need for prospective studies to better understand the natural history of cardiopulmonary and renal disease, their relationship to patient-important outcomes, and optimal management.

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Section: Recommendationmentioning

confidence: 99%

American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease

et al. 2019

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“…Mbong et al [21] reported a prevalence rate of NE of 100% in children with SCA and OSA compared to 46.2% in those without OSA (P 0.004). In a recent study from Saudi Arabia NE was reported in 62% of children with SCA and Obstructive apneahypoapnea index (OAHI) ≥ 1 compared to an overall prevalence rate of 46% [23]. Lehman and colleagues demonstrated in their study that habitual snoring and SDB with and without habitual snoring are associated with enuresis in children with SCA.…”

Section: Ne and Upper Airway Obstruction Are They Related?mentioning

confidence: 98%

“…Obstructive sleep apnea (OSA) is the commonest of these disorders [57]. Few studies have described sleep-disordered breathing and OSA in children and adolescent with SCA using polysomnography(PSG) [23,[58][59][60][61][62]. OSA was reported in 10-80% of children with Sickle cell disease [58][59][60][61][62]23].…”

Section: Ne and Sleep-related Disorders In Scamentioning

confidence: 99%

“…SCA were retrieved after thorough literature search (Table 1A-1C) [4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. We categorized these articles in 3 groups according to the criteria used to define NE.…”

Section: Introductionmentioning

confidence: 99%

“…Group 3 (Table 1c): These are the studies that used different diagnostic criteria, they reported a prevalence rate of 32.2%-68.9% [4,[16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed¹

2017

Med Surg Urol

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Children with sickle cell anemia (SCA) have a tendency to have nocturnal enuresis (NE) more than normal children with males being more affected than females. Mechanisms of NE that operate in normal children probably do so in children with SCA. Postulated causes of nocturnal enuresis in individuals with SCA include hyposthenuria causing nocturnal polyuria, reduced bladder capacity or nocturnal bladder overactivity, sleep disordered breathing and an increased arousal thresholds. The variation in the reported prevalence rate of NE in SCA is probably due to differences in definition criteria and methodology. This review will discuss the prevalence rate and postulated causes of NE in children with SCA.

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Pediatric Obstructive Sleep Apnea and Sickle Cell Disease: Demographic and Polysomnographic Features

et al. 2023

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Objective Obstructive sleep apnea (OSA) is prevalent in children with sickle cell disease (SCD). We compared the demographic, clinical, and polysomnographic characteristics of children with and without SCD. Methods This retrospective chart review included children with SCD (n = 89) and without SCD (n = 192) ages 1–18 years referred for polysomnography (PSG) for OSA. Results Children with SCD were predominantly African American when compared to the non‐SCD group (95% vs. 28%, p < 0.001). The non‐SCD group had a higher BMI z‐score (1.3 vs. 0.1, p < 0.001) and a higher percentage of patients classified as obese (52% vs. 13%, p < 0.001). In children with SCD, 43% had severe OSA and 5.6% had no OSA. In the non‐SCD group, 67% had severe OSA and 4.7% had no OSA. The SCD compared to the non‐SCD group had a lower mean apnea‐hypopnea index (AHI) (13.6 vs. 22.4, p = 0.006) but a higher percent sleep time below 90% oxygen saturation (10.5% vs. 3.5%, p < 0.001). Predicted probability for severe OSA in children with SCD decreased with increasing age (OR = 0.81, 95% CI: 0.70–0.93). Conclusion Children with SCD referred for PSG are at risk for severe OSA. Compared with the non‐SCD group, most children were African American with lower rates of obesity and lower AHIs but longer periods of nocturnal hypoxemia. Likelihood for severe OSA decreased with increasing age for the SCD group. Level of Evidence 3, retrospective comparative study Laryngoscope, 133:1766–1772, 2023

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Prevalence of obstructive sleep apnea in children with sickle cell disease at a tertiary hospital in Saudi Arabia

Cited by 19 publications

References 20 publications

American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease

American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Pediatric Obstructive Sleep Apnea and Sickle Cell Disease: Demographic and Polysomnographic Features

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