Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome

Likar-Manookin, K; Stewart, Carol M.; Al‐Hashimi, Ibtisam; Curtis, William J. R.; Berg, Kathleen M.; Cherian, Kotturathu Mammen; Lockhart, Peter B.; Brennan, Michael T.

doi:10.1111/odi.12044

Cited by 22 publications

(34 citation statements)

References 19 publications

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“…Lichen planus has been associated with a number of disorders, generally of autoimmune origin: myasthenia gravis, Sjögren's syndrome, ulcerative colitis, psoriasis, thymoma, lupus erythematous, coeliac disease. Likewise, Sjögren's syndrome, lupus erythematous, type 1 diabetes and pernicious anaemia have also been associated with OLP …”

Section: Discussionmentioning

confidence: 99%

“…Autoimmune diseases are complex disorders caused by a combination of genetic susceptibility and environmental factors. Previous research has produced evidence of a greater frequency of autoimmune diseases among OLP patients than among the general population, although this association might be merely accidental rather than linked to autoimmune pathogenesis …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study

López‐Jornet

Parra-Perez

Pons-Fuster

2013

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study

López‐Jornet

Parra-Perez

Pons-Fuster

2013

Acad Dermatol Venereol

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“…Although the etiology of OLP remains uncertain, there have been reports that described many systemic disorders linked to OLP such as metabolic syndrome [25], mental disorders [26], immune disease [27,28] and viral infection [29]. The association of these pathologies with OLP appears to depend upon geographic factors [30].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study

García-Pola¹,

Llorente-Pendás²,

Romero³

et al. 2016

Dermatology

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Background: Thyroid disease has been mentioned to have a possible relation to the development of oral lichen planus (OLP). Objective: Because goiter is considered endemic in many countries, we proposed to determine whether thyroid disease constitutes a comorbidity of OLP. Methods: Two hundred and fifteen patients diagnosed as having OLP were evaluated concerning their serum thyroid-stimulating hormone and thyroxine (T₄) levels. The results were contrasted with those obtained in control series of the same number of subjects matched for age and sex. Results: Diagnosis of thyroid disease was present in 15.3% of OLP patients (33/215) and in 5.2% (12/215) of the control group. In relation to OLP patients, the odds ratio of presence of thyroid disorders was 3.06 and that of using levothyroxine medication 3.21. Conclusions: In the present study, OLP patients were associated with thyroid disease, specifically with hypothyroidism. Because most thyroid patients need T₄ treatment, our findings confirmed that OLP and thyroid disease could be comorbidities.

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“…An autoimmune reaction by cytotoxic T lymphocytes to these activated keratinocytes may result in the tissue destruction which is clinical characteristic of OLP [49]. Several investigators have implicated an association between LP and other immune-mediated diseases sush as psoriasis [16,17], coeliac disease [18,19], rheumatoid arthritis and Sjogren's syndrome [20]. Although, those reports are quite rare and the epidemiological evidence for this is scant.…”

Section: Discussionmentioning

confidence: 90%

“…Previous research has also produced some evidence of a higher frequency of some diseases, generally of autoimmune origin among OLP patients than among the general population (myasthenia gravis, vitiligo, alopecia areata, thymoma, ulcerative colitis, psoriasis, celiac disease, Sjögren's syndrome and rheumatoid arthritis). However this association might be merely accidental rather than linked to autoimmune pathogenesis [14][15][16][17][18][19][20]. So, there is some controversial about mentioned links with OLP.…”

Section: Introductionmentioning

confidence: 99%

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Čanković¹

2016

J. Dent. Sci. Ther

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Oral lichen planus (OLP) is a still poorly understood and relatively common chronic inflammatory disease of oral mucosa. A connection between OLP and certain diseases have been reported in the past, such as diabetes, hypertension, hepatitis C infection (HCV), thyroid disease, and malignant diseases. There is some controversial about mentioned link with OLP. The study objective was to investigate association between autoimmune diseases and OLP in Northern Serbian province. A total of 48 patients (33 females and 15 males, ranged 29-84 years, mean age 59.8 ± 13.0) with clinical and histopathological proven OLP, along with 71 matched controls without oral mucosa lesions were included in the study. This was a retrospective case-control study conducted in patients who were treated at the Dental Clinic, Faculty of Medicine, University of Novi Sad, between January 2010 and Jun 2016. Clinical characteristics of OLP lesions, other oral mucosal diseases, presence of cutaneous LP, medical and family history with special regard to their autoimmune diseases with medication intake were recorded. Association regarding total of autoimmune diseases was found significant especially in prevalence of thyroid gland diseases. This study indicates connection between thyroid gland disorders (Hashimoto thyroiditis) and OLP. There is a need for further investigations such a screening for asymptomatic OLP in woman over the 40 years old suffering from thyroid gland disorders, particularly hypothyroidism.

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Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome

Abstract: The results of our analysis suggest that patients with pSS have a 12% prevalence of OLAIE with a wide range (7.3-21.2%) found between practices. This difference is likely related to the different screening protocols for oral dryness between sites.

Cited by 22 publications

References 19 publications

Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study

Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study

Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

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