Prevalence of oral lichen planus in patients with diabetes mellitus

Dis, Margot L. Van; Parks, Edwin T.

doi:10.1016/s1079-2104(05)80302-6

Cited by 56 publications

(35 citation statements)

References 24 publications

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“…The drugs now most commonly implicated in OLPlike lesions are the non-steroidal anti-inflammatory drugs and the angiotensin-converting enzyme inhibitors (Potts et al 1987, Firth andReade, 1989;Robertson and Wray, 1992;Van Dis and Parks, 1995). Other drugs known to cause lichenoid eruptions include thiazides, diuretics, penicillamine, beta-blockers, quinine and quinidine, para-amino salicylic acid, phenothiazines, carbamazepine, allopurinol, lithium, lorazepam, ketoconazole, streptomycin, isoniazid, metopromazine, levopromazine, amiphenazole, pyrimethamine, levamisole, beta-blocking agents, cinnarizine, flunarizine, gold, cyanamide (calcium carbamide), and many others (Table 5) (Shatin et al, 1953;Groth, 1961;Baker et al, 1964;Dinsdale et al, 1966;Roberts and Marks, 1981;Chau et al, 1984;Hogan et al, 1985;Colvard et al, 1986;Markitziu et al, 1986;Torrelo et at., 1990).…”

Section: (3) Drugsmentioning

confidence: 99%

“…Some authors have reported impaired glucose metabolism in a high percentage of OLP patients (Lundstrom, 1983), but these results have not been confirmed by others (see Table 9), and in any event, it is now widely recognized that impaired glucose tolerance is not synonymous with diabetes. Indeed, several studies have now shown only low prevalences of OLP in large groups of diabetic subjects (Borghelli et al, 1993;Lozada-Nur et al, 1985;Albrecht et al, 1992;Van Dis and Parks, 1995), such that the suggested association may be only coincidental or caused by anti-diabetic or other drugs. Nevertheless, in diabetics with OLP, there may be a higher prevalence of lingual involvement and of erosive lesions (Bagan et al, 1993).…”

Section: (8) Stressmentioning

confidence: 99%

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Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

476

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: (3) Drugsmentioning

confidence: 99%

Section: (8) Stressmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

476

461

View full text Add to dashboard Cite

show abstract

“…Overall, the minimum age was 8 years. Seven studies (13, 14, 16, 17, 19, 20, 22) were age-matched. The mean age of DM patients and control subjects was 51 and 47.7 years, respectively.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Oral Lichen Planus in Diabetes Mellitus: a Meta-Analysis Study

Mozaffari

Sharifi

2016

Acta Inform Med

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Background:Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.Methods:In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Strategy search was the Medical Subject Heading (MeSH) term oral lichen planus or oral mucosa combined with diabetes in PubMed and this search in other databases. Heterogeneity between estimates was evaluated by the Q and I2 statistic. Also, publication bias was assessed through funnel plot analysis with the Kendall’s and Egger’s tests.Results:From 831 studies were identified with different search strategies, 11 studies met the criteria to be included in meta-analysis (11 case-control studies). The overall prevalence of OLP in 11 studies with 4937 DM patients and 3698 control subjectswas 1.5% and 0.75%, respectively. In this meta-analysis, the OR in prevalence of OLP in DM patients compared with control subjects was 1.584 (95%CI1.013-2.477; P=0.044) with a low level of heterogeneity (I2 = 0%) that the result showed the prevalence of OLP in DM patients is significantly more than control subjects.Conclusions:This meta-analysis study showed an association between OLP with DM, whereas this association was no significant in previous studies, it was probably because different selecting of age, sex, type of DM, medications and criteria. Totally, the meta-analysis showed the risk of OLP in DM was higher compared with control subjects.

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“…2 Its true prevalence is unknown, but incidence is reported to be approximately 0.5-2%. 3,4 The lesions in OLP are usually bilateral and most commonly affect the posterior buccal mucosa, gingiva, and tongue. 4 OLP predominantly affects the middleaged population (50-55 years old), although it may be seen in persons of any age; 5 women are more susceptible.…”

Section: Introductionmentioning

confidence: 99%