Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia

Abstract

BackgroundThe purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms.MethodsThe study was a retrospective review of 100 consecutive pediatric patients, age 8–17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype.ResultsOverlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool.ConclusionsFD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD.

Sini‐San Regulates the NO‐cGMP‐PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

“…Most FD patients who are hypersensitive to gastric distention experience symptoms of epigastric pain and weight loss [25,26]. In this study, the body weight and 3-h food intake in FD model rats were significantly lower than those in normal rats, which was consistent with the behavioral scores and EMG activity results in rats.…”

Нарушения Моторно-Эвакуаторной Функции Желудка У Подростков С Гастроэзофагеальной Рефлюксной Болезнью И Функциональной Диспепсией

“…Однонаправленность моторно-эвакуаторных нарушений желудка у подростков с ФД и ГЭРБ указывает на общность патофизиологических механизмов развития этих заболеваний и обусловливает наличие общих клинических симптомов -у пациентов с ГЭРБ нередко наблюдаются симптомы ФД, и наоборот [20][21][22][23].…”

The “Biology‐First” Hypothesis: Functional disorders may begin and end with biology—A scoping review

“…As we deduced from our own data, 17 The same cohort also showed an increased prevalence of symptoms of overactive bladder (OAB) following the Giardia lamblia infection. 32 Bladder symptoms are frequently associated with intestinal symptoms of IBS 33 and with FD-type 34 in adults and in children 35 (20% in adults, higher in children). Since gut and bladder share common afferent (splanchnic) neural pathways and have close local proximity, coincidence of OAB and IBS symptoms is high 36 and common etiologies are to be expected.…”