Prevalence of Paget's Disease of Bone in Italy

Gennari, Luigi; Stefano, Marco Di; Merlotti, Daniela; Giordano, Nicola Giuseppe; Martini, Giuseppe; Tamone, Cristina; Zatteri, R; Lucchi, R. De; Baldi, Carlo; Vattimo, A; Capoccia, Silvia; Burroni, Luca; Geraci, Simone; Paola, Vincenzo De; Calabrò, Anna Rita; Avanzati, Annalisa; Isaia, Giancarlo; Nuti, Ranuccio

doi:10.1359/jbmr.050518

Cited by 75 publications

(37 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence in the UK is currently similar to that of Caucasian populations in other countries. In Italy, a recent prevalence study (12) has been conducted in the cities of Turin and Siena on the basis of x-ray, scintigraphy and biochemical tests. Among over 60 years of age, the overall incidence of the disease accounts for just over 1% and is greater among males with no significant differences between the two cities.…”

mentioning

confidence: 99%

Paget’s disease

et al. 2014

View full text Add to dashboard Cite

Paget’s disease of bone is the most common metabolic bone disease after osteoporosis and affects 2-4% of adults over 55 years of age. Its etiology is only partly understood and includes both genetic and environmental factors. The disease may be asymptomatic and can be uncovered incidentally on x-ray or in biochemical tests performed for another condition. It can also manifest itself with bone pain, deformity, fracture or other complications. Paget’s disease is diagnosed by x-rays and in general has very typical radiological features, but occasionally the clinical picture may be unusual and a differential diagnosis of sclerotic or lytic metastases needs to be considered. Plasma total alkaline phosphatase activity is the most clinically useful indicator of disease activity. It is elevated in most untreated patients, but may be within the normal range in patients with monostotic or limited disease. Bisphosphonate therapy is indicated for patients with symptoms and should also be considered in patients with disease sites that suggest a risk of complications, such as long bones, vertebrae or base of the skull. Orthopedic surgery in Paget’s disease patients includes almost exclusively the correction of fractures and arthroplasty.

show abstract

mentioning

confidence: 99%

Paget’s disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Moreover, an Italian survey on radiological, scintigraphic and biochemical data, showed that the prevalence of PDB in Italy, unlike the studies on British descent populations, did not exhibit a decreased secular trend [10]; (ii) a significant decline of the PDB-related mortality has been more recently reported in a US study (population of Olmsted County, MN) in which it has been showed that overall survival in the PDB analysed population was slightly better than expected when compared with white Minnesota residents, especially in affected male. Moreover, an increased risk of mortality resulting from cancer, cardiovascular disease, pulmonary disease or gastrointestinal disease has not been reported in this study [11]; (iii) a drastic fall down of PDB prevalence (standardized both for age and gender) between 1974 and 1994 (follow-up prevalence study in 10 towns in Great Britain), as also observed in other European Countries; on the contrary, a previous US survey on the incidence of PDB (still from Olmsted County, MN), covering the period 1950 through 1994, revealed an increased incidence over the first part of the study period and then a decline [12].…”

Section: Secular Trends Of Paget's Disease Of Bone: Conflicting Resultsmentioning

confidence: 86%

Genetic aspects of the Paget’s disease of bone: concerns on the introduction of DNA‐based tests in the clinical practice. Advantages and disadvantages of its application

Falchetti

Marini

Masi

et al. 2010

Eur J Clin Investigation

View full text Add to dashboard Cite

Background A large amount of genetic studies have clearly demonstrated the existence of a genetic susceptibility to Paget's disease of bone (PDB). Although the disease is genetically heterogeneous, the SQSTM1 ⁄ p62 gene, encoding a protein with a pathophysiological role in both osteoclast differentiation and activity, has been found worldwide to harbour germline mutations in most of the PDB patients from geographically distant populations originating from different areas of Europe, both in sporadic and familial cases.

show abstract

“…Finally, some studies have failed to show a reduction in disease prevalence or severity, but these have been undertaken either in low prevalence areas or over a relatively short time and therefore were underpowered to detect such change. (22,23) There has been much speculation as to what environmental agents might be important. Suggestions have ranged from childhood diet, physical activity, oral bacteria, viruses, zoonotic infections, to occupational exposures.…”

Section: Is the Prevalence Of Paget's Disease Of Bone Decreasing? P11mentioning

confidence: 99%