Prevalence of pain in patients with Parkinson's disease in Addis Ababa, Ethiopia

Hirsi, Jama Osman; Yifru, Yared Mamushet; Metaferia, Guta Zenebe; Bower, James H.

doi:10.1016/j.parkreldis.2018.09.030

Cited by 11 publications

(19 citation statements)

References 22 publications

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“…A similar pattern is reported by other authors as well. 4 , 8 , 9 , 22–25 The mean total KPPS score in our study was 41.2±26.8, which was higher than the results of some previous studies. 14 , 15 , 22 According to the Ford classification, the most common types of PD-related pain are musculoskeletal pain and dystonia-related pain, followed by neuropathic radicular pain and central pain, which is consistent with the results of a previous study.…”

Section: Discussioncontrasting

confidence: 89%

“…In the present study, the prevalence of PD-related pain was 44.5%, which was lower than the average reported in the literature. The prevalence of PD-related pain in the current literature is approximately 60% on average and varies from 40% to 85%; 8 , 9 , 18 this wide range is related to a lack of objective methods for pain measurement, different patient groups, and the methods of data collection. In addition, the diagnosis and treatment of PD related pain is complex in case of prevalent comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…About 40–85% of the patients with PD suffer from various types of pain, 6 , 8 , 9 however, most of them do not receive appropriate and regular analgesic treatment because it is poorly understood and the amount of pain is not accurately measured. 10 , 11 Before the King’s Parkinson’s disease Pain Scale (KPPS) was published as the first disease-specific scale to assess pain in PD, most of the descriptive data on pain in PD was obtained using non-disease-specific assessment tools.…”

Section: Introductionmentioning

confidence: 99%

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Pain Assessment in Chinese Parkinson’s Disease Patients Using King’s Parkinson’s Disease Pain Scale

Gao¹,

Huang²,

Cai³

et al. 2022

JPR

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Purpose To assess Parkinson’s disease (PD)-related pain using the Chinese translation of King’s Parkinson’s disease Pain Scale (KPPS). Patients and Methods A cohort of 200 patients with primary PD was recruited for this study. Their demographic and clinical features, including age, disease duration, levodopa equivalent daily dose (LEDD), and scores on the Unified Parkinson’s Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), Mini-Mental State Examination (MMSE), Activities of Daily Living Scale (ADL), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI), Visual Analogue Scale (VAS) and KPPS, were recorded. Results The prevalence of PD-related pain was 44.5%. Among the patients with PD-related pain, the average KPPS score was 41.2 ± 26.8. Pain was most commonly located in the lower limbs (60.7%), upper limbs (22.5%) and waist (21.3%). The most common pain type was musculoskeletal pain (68.5%). Compared with the PD group without pain, the PD group with pain had a longer disease duration ( p = 0.022), higher LEDD ( p = 0.008), higher UPDRSIII score ( p = 0.018), higher H&Y stage ( p = 0.003), higher HAMD score ( p < 0.001), higher HAMA score ( p < 0.001), lower ADL score ( p = 0.046) and higher PSQI score ( p < 0.001). PD-related pain was correlated with the H&Y stage and the PSQI score ( p < 0.05). Cut-off points of 0, 34, and 70 were obtained to discriminate pain severity levels between no pain, mild, moderate, and severe pain, respectively. Conclusion Chinese version of KPPS is not only an easy tool for characterization and scoring of pain in PD patients but also has the ability to distinguish between different levels of pain severity.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pain Assessment in Chinese Parkinson’s Disease Patients Using King’s Parkinson’s Disease Pain Scale

Gao¹,

Huang²,

Cai³

et al. 2022

JPR

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“…Furthermore, most of the PD patients were in their early disease stages. These demographic findings were congruent with previous reports from Ethiopia ( 15 , 22 , 23 ). Nearly all the individuals diagnosed with PD were on levodopa treatment, and close to half of them were on anticholinergic drugs, which may have contributed to the development of OH in PD patients.…”

Section: Discussionsupporting

confidence: 92%

Frequency and Factors Associated with Orthostatic Hypotension in Individuals with Parkinson’s Disease: A Case-Control Observational Study

Mengesha

2022

Ethiop J Health Sci

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BACKGROUND: Orthostatic hypotension (OH) is a common and considered the most incapacitating non-motor symptom of Parkinson’s disease (PD). Little is known about OH in Ethiopian PD patients. The objectives of the present study were to determine the frequency and factors associated with OH in individuals diagnosed with PD compared to a healthy control. Methods: A multi-center case-control observational study was conducted. A total of 53 PD cases and 53 age and sex matched healthy controls were included. Both descriptive and Chi-square proportional statistical analysis were used. RESULTS: The mean age distribution was comparable between the two study groups (61.9 vs. 59.9 years). Distribution of male gender was comparable between PD and control groups (71.7% vs. 67.9%). Nearly all the individuals diagnosed with PD were on levodopa treatment, and close to half of them were on anticholinergic drugs. Hypertension was the commonest comorbid disorder in both groups. The prevalence of orthostatic hypotension was higher in PD patients (22.6%) compared to the control group (9.4%). The proportion of constipation (p=0.007), urinary urgency (p=0.007), and nocturia (p<0.0001) was significantly higher among Parkinson’s disease patients compared to the healthy control group. Falls and excessive sweating were only reported by PD patients. CONCLUSION: The present study shows the frequency of orthostatic hypotension in Ethiopian Parkinson’s disease patients is comparable to other regions. The presence of constipation, urinary urgency, and nocturia was associated with Parkinson’s disease compared to the control group.

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“…To our knowledge this is the rst study to report white matter hyperintensity and predictors in PD patients in Ethiopia. The mean age of study participants was comparable to previous reports from Ethiopia (13,14). Majorities of the participants were males; were on levodopa; and tremor dominant.…”

Section: Discussionsupporting

confidence: 78%

White Matter Hyperintensity in Parkinson’s Disease Patients in Addis Ababa, Ethiopia

Ayele

Gulelat²,

Zebenigus

et al. 2021

Preprint

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Background: The clinical significance of white matter hyperintensity (WMH) on brain magnetic resonance image (MRI) in Parkinson’s disease (PD) patients was not sufficiently understood. Little is known about WMH in PD patients in sub Saharan Africa (SSA). The objectives of this study were to determine white matter hyperintensity and associated factors in Ethiopian PD patients.Method: A cross-sectional observational study was conducted in 42 PD patients with WMH and 42 PD patients with normal MRI in Addis Ababa, Ethiopia. Both descriptive and analytical statistics were used to analyze the data. Results: Total of 84 patients with PD was included in the analysis. The overall mean age was 61.5 (11.6) years. Young onset PD (≤ 50 years) accounted 16.7%. Males accounted 67.9%. Tremor dominant PD accounted 88.1%. Forgetfulness and hallucination was reported by 8.3% and 13.1% respectively. The median serum vitamin D and the mean hemoglobin level was 14.9 (8.3 – 20.2) ng/mL and 14.8 (13.8) g/L respectively. Hypovitaminosis D was observed in 40.5% of PD patients; similarly, anemia was observed in 27.4%. Negative correlation was observed between participant’s age and their respective hemoglobin level. The prevalence of hypertension, diabetes, and dyslipidemia was 29.8%, 13.1%, and 20.2% respectively. No association was observed between white matter hyperintensity and young onset PD, hypovitaminosis D, hypertension, and diabetes. Age and dyslipidemia were found to be independent predictor of white matter hyperintensity, when adjusted for the covariates.Conclusion: The present study indicates advanced age and dyslipidemia were associated with increased risk of having white matter hyperintensity on brain MRI of Ethiopian PD patients compared to those patients with normal MRI. Even though non-significant, the trend of vascular risk factors was in line with WMH.

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Prevalence of pain in patients with Parkinson's disease in Addis Ababa, Ethiopia

Cited by 11 publications

References 22 publications

Pain Assessment in Chinese Parkinson’s Disease Patients Using King’s Parkinson’s Disease Pain Scale

Pain Assessment in Chinese Parkinson’s Disease Patients Using King’s Parkinson’s Disease Pain Scale

Frequency and Factors Associated with Orthostatic Hypotension in Individuals with Parkinson’s Disease: A Case-Control Observational Study

White Matter Hyperintensity in Parkinson’s Disease Patients in Addis Ababa, Ethiopia

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