Prevalence of paratuberculosis infection in dairy cattle in Northern Italy

Pozzato, Nicola; Capello, Katia; Comin, Arianna; Toft, Nils; Nielsen, Søren Saxmose; Vicenzoni, G.; Arrigoni, N.

doi:10.1016/j.prevetmed.2011.07.001

Cited by 46 publications

(36 citation statements)

References 10 publications

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“…It was assumed that no on-farm MAP controls were in place, with the potential for rapid within-herd transmission and high within-herd prevalence some years after initial MAP introduction (Marcé et al, 2011a;also Figure 1 and Table 3). We acknowledge that the figures are higher than often reported (Pozzato et al, 2011;Raizman et al, 2011), which may be due to ongoing interventions that are either JD-specific or that inadvertently control JD. Nonetheless, care is needed when evaluating point estimates of (apparent) prevalence from infected farms to ensure that these are compared with simulated apparent (and not true) within-herd prevalence.…”

Section: Discussionmentioning

confidence: 53%

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Cameron

Strain

et al. 2015

Journal of Dairy Science

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As part of a broader control strategy within herds known to be infected with Mycobacterium avium ssp. paratuberculosis (MAP), individual animal testing is generally conducted to identify infected animals for action, usually culling. Opportunities are now available to quantitatively compare different testing strategies (combinations of tests) in known infected herds. This study evaluates the effectiveness, cost, and cost-effectiveness of different testing strategies to identify infected animals at a single round of testing within dairy herds known to be MAP infected. A model was developed, taking account of both within-herd infection dynamics and test performance, to simulate the use of different tests at a single round of testing in a known infected herd. Model inputs included the number of animals at different stages of infection, the sensitivity and specificity of each test, and the costs of testing and culling. Testing strategies included either milk or serum ELISA alone or with fecal culture in series. Model outputs included effectiveness (detection fraction, the proportion of truly infected animals in the herd that are successfully detected by the testing strategy), cost, and cost-effectiveness (testing cost per true positive detected, total cost per true positive detected). Several assumptions were made: MAP was introduced with a single animal and no management interventions were implemented to limit within-herd transmission of MAP before this test. In medium herds, between 7 and 26% of infected animals are detected at a single round of testing, the former using the milk ELISA and fecal culture in series 5 yr after MAP introduction and the latter using fecal culture alone 15 yr after MAP introduction. The combined costs of testing and culling at a single round of testing increases with time since introduction of MAP infection, with culling costs being much greater than testing costs. The cost-effectiveness of testing varied by testing strategy. It was also greater at 5 yr, compared with 10 or 15 yr, since MAP introduction, highlighting the importance of early detection. Future work is needed to evaluate these testing strategies in subsequent rounds of testing as well as accounting for different herd dynamics and different levels of herd biocontainment.

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Section: Discussionmentioning

confidence: 53%

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Cameron

Strain

et al. 2015

Journal of Dairy Science

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“…Çalışmamızda ELISA yöntemiyle pTB'un seroprevelansı %3.5 olarak tespit edildi. Çalışmamızda dahil genel olarak pTB Türkiye'deki prevalansını %0 ile %20 arasında değişmesi Avrupa'daki prevalans aralığı (%0-%24) ile paraleldir [2,5,15,16] . Türkiye'de pTB'la ilgili çalışmalarda çiftlik prevalansının dikkate alınmadığı görülmektedir.…”

Section: Tartişma Ve Sonuçunclassified

“…Bu iki çalışma verileri yaklaşık olarak her iki işletmeden birinde pTB'un bulunduğunu göstermektedir. Avrupa ülkelerinde pTB'un sürü prevalansının %0 ile %75 arasında değiştiği bildirilmiştir [2,5,15,16] . Çiftlikteki hayvan sayısı arttıkça ve özellikle >100 olanlarda pTB'un prevalansının da arttığı belirtilmiştir [4,16,17] .…”

Section: Tartişma Ve Sonuçunclassified

“…pTB'un subklinik dönemde teşhis önemli bir problemdir. Enfeksiyonun subklinik teşhisinde serolojik olarak spesifik antikorların belirlenmesi ve nekropsi esnasında doku veya dışkıdan MAP'ın kültürü en etkili yöntemlerdir [15] . Kültür yöntemi yüksek spesifiteye sahip olmakla beraber uzun inkübasyon süresi kullanımını sınırlandırmaktadır [9] .…”

Section: Tartişma Ve Sonuçunclassified

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Kars Yöresi Sığırlarında Subklinik Paratuberkülozun Seroprevalansı

Makav¹

2013

Kafkas Univ Vet Fak Derg

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“…Na Bélgica, 18% dos rebanhos não vacinados e 0,87% dos animais testados apresentaram soropositividade para MAP (Boelaert et al, 2000). Na Itália, foram verificadas prevalências de 2,6% na região de Lombardy e 4,0% na região de Veneto (Pozzato et al, 2011). Por outro lado, na Austrália, a prevalência varia entre 9 a 22% (Manning;Collins, 2001).…”

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Paratuberculose em pequenos ruminantes domésticos

et al. 2012

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RESUMOMycobacterium avium subesp. paratuberculosis (MAP) é o agente etiológico da paratuberculose em ruminantes domésticos e silvestres. Em caprinos e ovinos causa uma enterite granulomatosa crônica com emagrecimento progressivo seguido de morte, raramente a diarreia é observada. Nesse aspecto, a doença é considerada uma ameaça mundial aos rebanhos, pois pode permanecer no estádio subclínico por anos, manifestando perdas indiretas na produção animal e na disseminação do agente. Além disso, existem relatos da possível relação de MAP com a doença de Crohn, determinando, assim, a sua relevância na saúde pública. O Brasil não dispõe de dados quantificando as reais perdas produtivas nos rebanhos acometidos pela doença, e poucas informações do comprometimento de caprinos e ovinos no país são relatadas. Assim, este artigo busca revisar a paratuberculose em pequenos ruminantes domésticos. PALAVRAS-CHAVE:Mycobacterium avium subesp. paratuberculosis, ovinos, caprinos. ABSTRACT PARATUBERCULOSIS IN SMALL DOMESTIC RUMINANTS. Mycobacterium avium subsp.paratuberculosis (MAP) is the causative agent of paratuberculosis in domestic and wild ruminants. In sheep and goats it causes a chronic granulomatous enteritis with progressive emaciation and death, diarrhea rarely being observed. In this aspect, the disease is considered a worldwide threat to livestock, as it may remain subclinical for years, with indirect losses in production and agent dissemination. In addition, there are reports of a possible relationship with the agent of Crohn's disease, so it is also of relevance to public health. Brazil does not have any data quantifying the actual production losses in herds affected by the disease, and few details of the involvement of goats and sheep in the country have been reported. Thus, this paper aims to review the occurrence of paratuberculosis in flocks of domestic small ruminants. KEY WORDS: Mycobacterium avium subsp. paratuberculosis, sheep, goats.A paratuberculose é uma doença bacteriana contagiosa crônica do trato intestinal que afeta predominantemente ruminantes domésticos e silvestres (Chiodini et al., 1984;Clarke, 1997; ayele et al., 2001;Mota et al., 2010), causada pelo Mycobacterium avium subesp. paratuberculosis (MAP), da família Mycobacteriaceae. Estes são bastonetes aeróbicos, imóveis, catalase positiva, sendo considerados Gram positivos (tiMMs et al., 2011). Por apresentarem grande quantidade de ácido micólico e lipídios na parede celular, coram-se melhor pela técnica de Ziehl-Neelsen, onde a fucsina carbólica se liga aos lipídeos da parede celular, resistindo ao descorante álcool-ácido, sendo classificados como bacilos álcool-ácido resistentes (BAAR) (Quinn et al., 2005). Essa característica lipídica em sua parede celular confere elevada resistência no meio ambiente. Whittington et al. (2004) demonstraram que MAP pode permanecer viável em solos sombreados por mais de 55 semanas, sendo resistentes à maioria dos desinfetantes comumente utilizados (Collins, 2003). Recentemente, foi verificado que MAP pode também uti...

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Prevalence of paratuberculosis infection in dairy cattle in Northern Italy

Cited by 46 publications

References 10 publications

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Kars Yöresi Sığırlarında Subklinik Paratuberkülozun Seroprevalansı

Paratuberculose em pequenos ruminantes domésticos

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