Prevalence of pathologic gastroesophageal reflux in regurgitant infants

Abstract

Objective: To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria. Method:The study design was transversal. The patients were all children of less than 1 year of age with a history of episodes of regurgitation for at least 3 weeks. The study group was comprised of 798 children who attended the program between January and August of 2002. The diagnostic criteria were based on Rome II criteria.Results: The prevalence of pathologic gastroesophageal reflux was 11.15% (89/798) (95% CI 9.10-13.48). It was higher during the first two trimesters of life, 14.62% (31/212) (95% CI 10.33-19.86) in the first trimester, and 13.76% (38/276) (95% CI 10.07-18.21) in the second trimester. Conclusion:The prevalence of pathologic gastroesophageal reflux within the group of children examined concurred with previously published studies, with predominance, therefore, of regurgitant infants. ARTIGO ORIGINAL IntroduçãoEm crianças saudáveis menores de 2 anos de idade, os episódios de refluxo gastroesofágico fisiológico muitas vezes são sintomáticos, sendo a regurgitação o sintoma característico. Recentemente essa situação foi denominada regurgitação infantil (RI), a qual deve ser diferenciada do refluxo gastroesofágico patológico (RGEP), que se associa à sintomatologia clínica e é denominado doença do refluxo gastroesofágico (DRGE) 1-3 .

G-protein β3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese

“…Gastro-esophageal reflux disease is the most common esophageal disorder of children, affecting about 11% of all infants during their first year of life. 34 Epidemiological data justify theory formation about a genetic component in the pathophysiology of GERD. The disease etiology is further complicated by a substantial genetic contribution as shown by familial clustering, 35 autosomal dominant familial transmission of disease 36,37 as well as twin studies.…”

4-Aminobutyrate Aminotransferase (ABAT): Genetic and Pharmacological Evidence for an Involvement in Gastro Esophageal Reflux Disease

“…It has been suggested that GERD may originate in childhood [1], [7]–[10]. In fact, GERD is the most common esophageal disorder in children and 11% of infants are affected during their first year of life [11]. However, there are differences between pediatric and adult GERD such that the erosive form of the disease is rarely seen in the young [12].…”