Prevalence of Peyronie's disease in men over 50-y-old from Southern Brazil

Rhoden, Ernani Luı́s; Telöken, Cláudio; Ting, Hu; Lucas, Márcio Luı́s; Ros, Carlos; Souto, Carlos Ary Vargas

doi:10.1038/sj.ijir.3900727

Cited by 90 publications

(63 citation statements)

References 17 publications

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“…4,12 For example, a prospective prevalence study (n = 1440) demonstrated that comorbid PD significantly increased the duration (P <.05) and severity of symptoms (P <.05) in patients with ED. 12 However, the underlying mechanisms for PD-associated ED remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prevalence of PD ranges from 3.2% to 11.8% of men, depending on the definition of PD used and the population studied. [2][3][4] The underlying cause of PD is unknown but likely involves abnormal wound healing. 5 This abnormal response facilitates collagen deposition, changes in collagen fiber content, and plaque formation.…”

mentioning

confidence: 99%

“…PD is often associated with sexual dysfunction (eg, erectile dysfunction [ED]), 4,12 and PD may impact the course of ED. Factors underlying this connection remain unknown, 13 but both conditions have been associated with increased age, 2,14-16 comorbid disorders (eg, diabetes, 2,8,16 cardiovascular events, 17,18 radical prostatectomy 19,20 ), psychological symptoms, [9][10][11]15,21,22 and altered blood flow.…”

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confidence: 99%

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Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Şerefoğlu

Smith²,

Kaufman³

et al. 2017

Urology

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OBJECTIVETo elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD). METHODSA post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum ( RESULTSPain during intercourse (P = .02) and PD bother (P <.0001) had a significant impact on International Index of Erectile Function, erectile function scores. The Peyronie's Disease Questionnaire bother domain score was significantly affected by penile curvature deformity, penile shortening, pain during intercourse, and the presence of plaques (P ≤.0005 for all), with pain during intercourse having the greatest impact (maximum likelihood estimation ± standard error = .496 ± .030; P <.0001). Erectile function did not appear to be directly influenced by the presence of plaques, penile curvature deformity, or penile shortening but was associated with PD bother and penile pain. CONCLUSIONThis post hoc analysis provides a conceptual framework through which disease characteristics may impact PD-related bother and erectile function in patients with PD. UROLOGY 107: 155-160, 2017. © 2017 The Author(s). Published by Elsevier Inc. P eyronie disease (PD) is a penile condition that is characterized by focal fibrosis of the tunica albuginea that results in the formation of plaque(s), curvature or deformation of the penis, and, in some cases, pain. 1 The prevalence of PD ranges from 3.2% to 11.8% of men, depending on the definition of PD used and the population studied. [2][3][4] The underlying cause of PD is unknown but likely involves abnormal wound healing. 5 This abnormal response facilitates collagen deposition, changes in collagen fiber content, and plaque formation. [5][6][7] Most patients with PD present between the ages of 52 and 57 years. 2,8 Although pain typically resolves over time, 1 penile curvature or deformity persists and may impact patients' psychological health, relationships with their sexual partners, and emotional well-being. 9,10 For example, a singlecenter, cross-sectional study demonstrated that more than half of patients with PD experienced relationship problems because of the condition, and 81% reported emotional problems. 9 Furthermore, an observational study of 92 men with PD demonstrated that almost half (48%) indicated that they were depressed and that the depression had not resolved over time. 11 Interestingly, in that study, depression was significantly associated with patients' perception of penile shortening, 11 suggesting that depression may

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Şerefoğlu

Smith²,

Kaufman³

et al. 2017

Urology

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“…Patients were screened for ED using the Sexual Health Inventory for Men. 8 ED severity was classified into the following five categories based on International Index of Erectile Function-5 scores; severe (5-7), moderate (8)(9)(10)(11), mild to moderate (12)(13)(14)(15)(16), mild (17-21) and no ED (22-25).…”

Section: Methodsmentioning

confidence: 99%

The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction

et al. 2006

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We attempted in this study to investigate the prevalence of Peyronie's disease (PD) among diabetic patients with erectile dysfunction (ED). Two-hundred and six diabetic patients were further evaluated in this study. Forty-two (20.3%) patients had PD. There were significant associations between PD and risk factors of age, obesity and smoking. All patients with PD had also ED. Penile curvature was present in 82.1% of all patients with PD. Of the patients with PD, 25.4% had pain with or without erection. Significant associations between PD and ED and ED duration were detected. This study confirmed the high prevalence of PD among diabetic patients with ED. Further work is needed probing the mechanisms through which diabetes affects the pathogenesis of ED and PD.

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“…A similar prevalence was seen among 1100 men screened for prostate cancer in southern Brazil, with 3.7% of men over 50 reporting symptoms of penile angulation or plaque. 3 In another prostate screening program, penile plaque was identified in 8.9% of men. 4 Selection bias likely accounts for the 16% prevalence reported from tertiary referral centers treating men with erectile dysfunction (ED).…”

Section: Epidemiologymentioning

confidence: 99%

Peyronie's disease: a critical appraisal of current diagnosis and treatment

2008

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Peyronie's disease is a fibrotic disorder of the tunica albuginea of the penis resulting in varying degrees of penile curvature and sexual dysfunction. Diagnosis of the disorder is made by detailed sexual history and focused physical examination. A wide range of medical treatments has been employed to treat the disorder. Verapamil treatment administered by intraplaque injection is supported by generally consistent randomized controlled trials (RCT). Some RCT evidence exists to support the use of colchicine, potaba, L-carnitine and liposomal superoxide dismutase. Future studies of medical efficacy should focus on improving RCT design, implementation and results reporting to improve the quality of evidence generated by each study. The surgical treatment of Peyronie's disease is a viable and recommended alternative for men with compromised sexual function due to severe curvature or lesions causing penile instability. The choice of corrective procedure should be tailored to each patient after a detailed evaluation of disease severity and sexual function.

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Prevalence of Peyronie's disease in men over 50-y-old from Southern Brazil

Cited by 90 publications

References 17 publications

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

The prevalence of Peyronie's disease in diabetic patients with erectile dysfunction

Peyronie's disease: a critical appraisal of current diagnosis and treatment

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