Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures

Shindel, A.W.; Sweet, Genevieve; Thieu, William; Durbin‐Johnson, Blythe; Rothschild, Jennifer; Szabo, Robert M.

doi:10.1016/j.esxm.2017.06.001

Cited by 20 publications

(15 citation statements)

References 17 publications

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“…Moreover, it is also believed that there may be an underreporting of the disease because of patients' reluctance to seek diagnosis or treatment. 25 In this study, where patients with different urological complaints were attended, the prevalence of PD was 13.11% among the 656 patients interviewed. When stratified by age, it was possible to observe a higher prevalence of individuals in the agegroup 41e50 years (17.89%), followed by men in the agegroups of 61e70 and 51e60 years ( Figure 2).…”

Section: Discussionmentioning

confidence: 67%

Prevalence, Risk Factors, and Erectile Dysfunction Associated With Peyronie’s Disease Among Men Seeking Urological Care

Segundo

Glina

2020

Sexual Medicine

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Introduction: Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by an abnormality in collagen structure of penile tunica albuginea. Aim: We sought to investigate the prevalence, risk factors, and the relationship between erectile dysfunction (ED) and PD in male patients aged 30e80 years seeking urological care. Methods: This is a cross-sectional study using data collected from October 2016 to October 2017 in an outpatient clinic associated with the Brazilian Public Health System. All men aged 30 to 80 years were invited to participate. Data collected were related to the clinical history and sexual habits of patients using the International Index of Erectile Function, in addition to the physical examination of the penis and laboratory parameters. Main Outcome Measure: Descriptive statistics and multivariate logistic regression models tested the prevalence, risk factors, and the relationship between ED and PD in male patients. Results: The study included 656 individuals, who were distributed as per age, marital status, race, educational level, and income. Of these participants, 86 (13.11%) presented with fibrous plaques compatible with PD at the physical examination. Among the risk factors evaluated, PD was associated with diabetes, smoking, and obesity in 43.02, 64.17, and 26.74% of patients, respectively. The presence of penile plaques compatible with PD was more prevalent in men with ED, history of penile trauma, and complaint of penile deformity. There was a higher prevalence of plaques in the distal penis. Conclusion: The PD among the studied population was associated with risk factors such as diabetes, smoking, and obesity. Other clinical characteristics, such as history of penile trauma, penile deformity, and ED, were reported in patients with PD. There was a higher prevalence of plaques in the distal penis, specifically in the corona of the glans penis. The prevalence of PD was different from that in the published literature, our results show that numbers thus more studies are needed.

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Section: Discussionmentioning

confidence: 67%

Prevalence, Risk Factors, and Erectile Dysfunction Associated With Peyronie’s Disease Among Men Seeking Urological Care

Segundo

Glina

2020

Sexual Medicine

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“… 11 , 12 In cross-sectional prevalence studies, PD prevalence rates were reported to be between 0.39% and 20.3%. 3 , 6 , 8 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 This broad spectrum of results may be a result of methodological distinctions and the variety of manifestations. To our knowledge, this is the first study which meticulously investigates both the prevalence of PD in a general male population and its association with possible comorbidities and sexual behaviors of participants via face-to-face interviews.…”

Section: Introductionmentioning

confidence: 99%

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

et al. 2020

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Introduction: Peyronie's disease (PD) prevalence varies between 0.39% and 20% and studies on PD prevalence are limited. Aim: This study aims to determine the prevalence of PD in males aged 30 years in Turkey and to evaluate etiological factors associated with it. Methods: The study was conducted in 12 regions of Turkey according to the Eurostat Nomenclature of Territorial Units for Statistics 1 classification and included 1,208 patients. Survey questionnaires including questions about demographic features and basic health status as well as about diagnosis and etiology of PD were put forth to the volunteers who agreed to participate in the study. Diagnosis of probable PD was established by evaluating the questionnaires. Patients with a diagnosis of congenital penile curvature were excluded from the group with PD. Chi-square test, Fisher's exact test, and Mann-Whitney U test were used. Main Outcome Measure: The primary outcome analyzed in this article was the prevalence rate of PD in Turkey and the associated comorbidities. Results: The prevalence of PD was determined as 5.3%. The rates of participants with PD were found to be the highest in the 50e59 years group (27%) and in the NorthEast Region (20%). Compared with participants without PD, participants with PD were older (median: 52 interquartile range [41e64] vs 45 [37e55]; P < .001) and the rates of smokers (73% vs 60.9%; P ¼ .036) and those having diabetes mellitus (17.5% vs 9.2%; P ¼ .045), hypertension (14.3% vs 6.9%; P ¼ .041), and heart failure were higher (7.9% vs 2.5%; P ¼ .027). Male with PD symptoms preferred their partners on top during sexual intercourse (15.2% vs 34.1%; P < .001). This is the first study to evaluate premature ejaculation prevalence and related comorbidities with face-to-face interviews. Conclusion: The prevalence of PD was 5.3% in Turkey. Besides advanced age, smoking, position of sexual intercourse, and presence of comorbidities especially diabetes mellitus, hypertension, and heart failure were the factors associated with PD prevalence.

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“…The incidence rate in men is about 10%, and the disorder is more common in older individuals (Stuntz, Perlaky, des Vignes, Kyriakides, & Glass, ). Its cause is unknown, though it is predicted to be associated with trauma (Devine, Somers, Jordan, & Schlossberg, ) and is also frequently comorbid with Dupuytren's contracture (Shindel et al, ). Treatment of PD primarily consists of surgery and medication; however, some of its symptoms are known to resolve without intervention (Hatzichristodoulou, Meisner, Gschwend, Stenzl, & Lahme, ).…”

Section: Introductionmentioning

confidence: 99%

A snapshot of intralesional verapamil injection in the treatment of Peyronie's disease today

Sadagopan¹

2019

Andrologia

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Studies assessing the efficacy of intralesional verapamil injection in the treatment of Peyronie's disease have yielded mixed results. The purpose of this meta‐analysis is to systematise the existing literature on the efficacy of intralesional verapamil injection when used in the treatment of Peyronie's disease. The treatment outcomes of seven different study groups identified by computerised literature search were compared with natural history outcomes and data from control groups of three studies involving placebo saline injection. An exploratory meta‐analysis was performed on the data due to differing patient populations, treatment protocols, and inconsistent selection and reporting of outcomes. Intralesional verapamil injection significantly improved sexual function (p < .0005) and penile curvature (p < .005) in individuals with Peyronie's disease. Decreases in pain may be significant after therapy but are questionable. The effect of verapamil on plaque size remains less impressive (p > .05). Intralesional verapamil injection has promise to positively impact a number of clinical outcomes of Peyronie's disease; however, a large, multicentre, randomised, controlled study with reliable protocols is needed to confirm the efficacy of treatment.

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Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures

Cited by 20 publications

References 17 publications

Prevalence, Risk Factors, and Erectile Dysfunction Associated With Peyronie’s Disease Among Men Seeking Urological Care

Prevalence, Risk Factors, and Erectile Dysfunction Associated With Peyronie’s Disease Among Men Seeking Urological Care

A Population-Based Study of Peyronie’s Disease in Turkey: Prevalence and Related Comorbidities

A snapshot of intralesional verapamil injection in the treatment of Peyronie's disease today

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