Prevalence of porcine circovirus 2 throughout China in 2015–2019: A systematic review and meta-analysis

Liu, Yi; Gong, Qing‐Long; Nie, Lan-Bi; Wang, Qi; Ge, Gui-Yang; Li, Dongli; Ma, Baoyi; Sheng, Chen-Yan; Su, Nuo; Zong, Ying; Li, Jianming; Kai-quan, Shi; Xue, Lei; Du, Rui

doi:10.1016/j.micpath.2020.104490

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…The prevalences of 33.2 to 42.0% estimated for 12-week-old to 24-week-old pigs are similar to those reported by previous studies for comparable age groups of pigs in countries such as Mainland China [25], Thailand [38] and Korea [39]. The prevalence in the sows (9.7%) is lower than the 35% reported by [25]. However, as with the PRRSV comparisons, the methodologies used in the PCV2 prevalence studies vary.…”

Section: Discussionsupporting

confidence: 89%

“…The prevalence of PCV2 in the farmed pig population in the HKSAR was 20.3%, similar to that reported in Korea [26] and the USA [21], but lower than that reported in Mainland China where overall prevalence was estimated at 46% [25]. The prevalences of 33.2 to 42.0% estimated for 12-week-old to 24-week-old pigs are similar to those reported by previous studies for comparable age groups of pigs in countries such as Mainland China [25], Thailand [38] and Korea [39]. The prevalence in the sows (9.7%) is lower than the 35% reported by [25].…”

Section: Discussionsupporting

confidence: 76%

“…In China, a recent review and meta-analysis used data from 53 studies with an overall of 29,051 samples to estimate the prevalence of PCV2 [25]. The overall prevalence was 46%, while nursery pigs had the highest prevalence and adult sows the lowest [25]. Similar results were reported in Yunnan Province (China), with 61% of samples PCV2 positive and the greatest positive proportions observed in nursery and fattening pigs [20].…”

Section: Introductionmentioning

confidence: 66%

“…However, as with the PRRSV comparisons, the methodologies used in the PCV2 prevalence studies vary. For example, many previous studies used biased sampling, utilizing previously collected samples; targeted specific age groups; or selected pigs to sample based on clinical signs [20,21,25,40,41].…”

Section: Discussionmentioning

confidence: 99%

“…With respect to PRRSV in different ages of pigs, prevalence is reported to decrease as pigs age [11]. In China, a recent review and meta-analysis used data from 53 studies with an overall of 29,051 samples to estimate the prevalence of PCV2 [25]. The overall prevalence was 46%, while nursery pigs had the highest prevalence and adult sows the lowest [25].…”

Section: Introductionmentioning

confidence: 99%

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First Study to Describe the Prevalence of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 among the Farmed Pig Population in the Hong Kong Special Administrative Region

Flay

Yang

Choi

et al. 2022

Veterinary Sciences

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Infection of pig farms with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) causes substantial economic losses globally. However, little epidemiological data of PRRSV and PCV2 in the Hong Kong Special Administrative Region (HKSAR) were available. This pilot study aimed to provide baseline information of the prevalences of PPRSV and PCV2 in the HKSAR. A complex survey was conducted from 3 February 2020 to 11 March 2021 on 29 of the 40 pig farms in the HKSAR, with five pigs each from seven age groups (representing key production stages) tested using a real-time PCR. Evidence of presence of PRRSV European strain (PRRSV-1), PRRSV North American strain (PRRSV-2) and PCV2 was confirmed on 48%, 86% and 79% of farms, with overall prevalences of 7.6% (95% CI: 4.8–10.3%), 12.2% (95% CI: 9.6–14.7%) and 20.3% (95% CI: 14.3–26.2%) in the HKSAR pig population based on pooling results from all pigs across all farms. PRRSV-1 and PRRSV-2 were more prevalent in younger pigs, with the highest prevalences of 32.1% (95% CI: 20.8–45.0%) and 51.5% (95% CI: 38.9–64.0%) for 8-week-old pigs. In contrast, the distribution of PCV2 prevalence across age groups appeared to be more symmetrical, with higher prevalences reported in pigs from 12 weeks old to 24 weeks old but lower prevalences in younger pigs and sows. The results of this study demonstrate that PRRSV-1, PRRSV-2 and PCV2 are widely spread across pig farms in the HKSAR, which indicates that the current farm management and control protocols should be improved. We recommend the implementation of on-farm intervention strategies combined with ongoing surveillance to reduce these viruses, and their consequences, in the HKSAR pig population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

First Study to Describe the Prevalence of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 among the Farmed Pig Population in the Hong Kong Special Administrative Region

Flay

Yang

Choi

et al. 2022

Veterinary Sciences

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Crystal structure of the dimerized of porcine circovirus type II replication‐related protein Rep′

et al. 2023

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Porcine circovirus type 2 (PCV2) can cause porcine circovirus-associated disease (PCVAD), which causes significant economic losses to the global pig industry annually. There are no effective antiviral drugs used to control and treat PCV2, and prevention is mainly obtained through vaccination. PCV2 genome replicates through the rolling circle replication (RCR) mechanism involving Rep and Rep 0 , so analyzing the holistic structure of Rep and Rep 0 will help us better understand the replication process of PCV2. However, there are no reports on the integral structure of Rep 0 and Rep, which seriously hinders the research of the viral replication. By using the x-ray diffraction method, the structure of the Rep 0 dimer was resolved by us in this study.Structural analysis revealed that Rep 0 is a dimer formed by the interaction of the C-terminal domain. The two Rep 0 form a positively charged groove, which may play an essential role in the viral binding of dsDNA. Together, this study help to understand the replication process of the virus and may also provide new insights into the development of antiviral drugs.

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Establishment and preliminary application of duplex fluorescence quantitative PCR for porcine circoviruses type 2 and type 3

Gao,

Wang,

Zhang

et al. 2024

Heliyon

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Prevalence of porcine circovirus 2 throughout China in 2015–2019: A systematic review and meta-analysis

Cited by 12 publications

References 26 publications

First Study to Describe the Prevalence of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 among the Farmed Pig Population in the Hong Kong Special Administrative Region

First Study to Describe the Prevalence of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 among the Farmed Pig Population in the Hong Kong Special Administrative Region

Crystal structure of the dimerized of porcine circovirus type II replication‐related protein Rep′

Establishment and preliminary application of duplex fluorescence quantitative PCR for porcine circoviruses type 2 and type 3

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