Prevalence of Post‐Chikungunya Infection Chronic Inflammatory Arthritis: A Systematic Review and Meta‐Analysis

Abstract

According to our results in the most conservative scenario, approximately 25% of CHIK cases would develop CHIK-CIR (34% if we just consider the most representative studies), and 14% would develop chronic arthritis.

Persistent Arthralgia Associated with Chikungunya Virus Outbreak, US Virgin Islands, December 2014–February 2016

“…At 12 months, case-patients were significantly (p<0.01) more likely than controls to report difficulty performing daily activities. Our unadjusted persistent arthralgia estimates at 6 (44%) and 12 (33%) months (Table 2) fall within the pooled estimate from a metaanalysis (40%, 95% CI 31%–49%) ( 4 ). …”

“…Although acute symptoms of CHIKV infection are well-documented ( 12 ), information on the prevalence of long-term sequelae remains limited to observational studies, many of which lack comparator groups ( 4 ). From our year-long study of 165 case-patients and 167 controls, we found an almost 3-fold increased risk for persistent arthralgia in CHIKV case-patients at 6 and 12 months after illness onset.…”

“…Acute symptoms of CHIKV infection often resolve within 7–10 days ( 3 ). However, 7%–79% of case-patients from previous outbreaks have reported persistent arthralgia for months after infection ( 4 – 8 ). Persistent arthralgia associated with CHIKV illness has been assessed in persons in Southeast Asia, South America, and Europe but not in the Caribbean ( 4 , 9 ).…”

A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome

“…Following acute infection, typically lasting for 1-2 weeks, approximately 35% of patients develop a second phase of illness; disabling, potentially chronic arthritis [7].…”

Electrocardiographic alterations in patients with chikungunya fever from Sucre, Colombia: A 42-case series

“…over 15,000 cases in Colombia during January-June, 2016) [2]. In this context, not only rheumatological compromise is important [3]. Recently, some authors have suggested that cardiovascular disorders such as arrhythmias, myocarditis, pericarditis, myocardial infarction have occurred in previously healthy cases [4].…”