Prevalence of potential drug interactions of clinical importance in primary health care and its associated factors / Prevalência de potenciais interações medicamentosas de importância clínica na atenção primária à saúde e seus fatores associados

Leite, Verônica Abreu; Resende, Karina Aparecida; Resende, Carlos Ananias Aparecido; Melo, Ana Elisa; Queiroz, Nathane S.; Vilela, Fernanda Coelho; Barcelos, Paulo; Cardoso, Bruna Mundim; Melo, Angelita Cristine de

doi:10.34119/bjhrv4n2-241

Cited by 3 publications

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“…Among the twenty-nine participants identified in hyperpolypharmacy for this study, sociodemographic, clinical, life habits, functional ability characteristics and drug interaction data were analysed. The prevalence of major and moderate interactions was higher than those observed by Leite et al [8] in a Primary Care Service but lower than in HIV patients [9]. The results revealed that certain characteristics were associated with minor, moderate, and/or major drug interactions more frequently than other characteristics.…”

Section: Discussioncontrasting

confidence: 56%

Nonagenarians in Hyperpolypharmacy: relationship between the level of drug interactions and sociodemographic, clinical, and functional characteristics

Rubert,

Riva,

Soares

et al. 2023

Braz. J. Hea. Rev.

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Aim: This research aimed to study the association of drug interactions and sociodemographic, clinical, and functional characteristics in nonagenarians in hyperpolypharmacy. Methods: This was a secondary analysis of an evaluation performed by the Multiprofessional Care for the Oldest-old Project in 2016, with participants identified in hyperpolypharmacy. Results: Results revealed that 69% of 29 participants had at least one major drug interaction, 41% had 10 or more moderate interactions, and 59% had minor interactions. The study revealed significant relationships for major drug interactions with the characteristics of recurrent urinary tract infections, anxiety, and palpitations. The study found near significance for white colour, not good general health and appetite, depression, and impaired cognition. For moderate drug interaction, findings showed a relationship near significance for females, perception of not good general health and appetite, hypertension, diabetes, urinary infection, depression scale change, agitation, pain, fatigue, and a fear of falling. For minor drug interactions, the study revealed significant findings for an association with depression, and apathy or sleepiness. There were findings near significance for an association with white colour, diabetes, agitation, pain, fatigue, and cough. Conclusion: Drug interactions are highly prevalent among nonagenarians in hyperpolypharmacy, with clinical and quality of life impact. Thus, they must be constantly evaluated for the presence of drug interactions at all levels of care, whether in primary care or in specialized care. A study with larger sample size and longitudinal contour is proposed to prove the importance of our observations.

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Section: Discussioncontrasting

confidence: 56%

Nonagenarians in Hyperpolypharmacy: relationship between the level of drug interactions and sociodemographic, clinical, and functional characteristics

Rubert,

Riva,

Soares

et al. 2023

Braz. J. Hea. Rev.

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“…They can occur due to administration of the wrong drug or dosage, drug-drug interactions, allergies, or intolerance to medication. These unintended and potentially harmful responses to drugs pose significant risks to patient safety and have been recognized as a major concern by regulatory bodies, healthcare professionals, and policymakers (Coleman;Pontefract, 2016;Leite et al, 2021). Understanding and addressing ADR are crucial endeavors in improving medication safety and enhancing the overall quality of patient care.…”

Section: Introductionmentioning

confidence: 99%

Promoting dental patient safety toward judicious medication usage: a review

Cruz,

Reis-Oliveira,

Garcez

et al. 2024

Braz. J. Hea. Rev.

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Objective: This critical review aimed to review strategies for health promotion and patient safety regarding the usage of drugs prescribed by dental practitioners. Methods: Manual searches were conducted on PubMed, Embase, and in the Cochrane database of systematic reviews using the keywords “dentistry”, “medication error”, “drug-related side effects and adverse reactions”, and “patient safety”. Publications by the World Health Organization, and the World Dental Federation were also searched to organize this review. Results: Several approaches have been identified to promote patient safety, including continuum education and training of practitioners, interdisciplinary work with clinical pharmacists, and electronic tools to aid practitioners in prescribing the adequate therapeutic regimen avoiding dosage errors and checking for potential drug interactions. Conclusion: Medication errors are common in dentistry, as such, it is fundamental that health professionals, patients, governments, and communities commit to advancing improvements and medication safety.

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Prevalence of Potential Drug-drug Interactions among Psychiatric Patients at Psychiatry Hospital in Sulaimani City

HamaSalih,

Rebwar Ghareeb Hama,

Sabir Hamid

et al. 2024

AJPS

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Background: Clinically significant drug-drug interactions can be defined as events in which the pharmacodynamics or pharmacokinetic characteristics of a drug are modified by coadministration of a second drug to the patient’s medication protocol, which can often lead to in an increase of serious adverse reactions. The probability of interactions increases with higher number of drugs administered. Objective: The objective of this prospective study was to determine the prevalence of potential psychotropic drug-drug interactions among hospitalized patients at Psychiatry hospital in Sulaimani city, and to identify the clinical consequence of such combinations. Method: The current study was involved recruiting the data regarding prescribed psychotropic drugs of 60 newly hospitalized psychiatric patients. Data collection on each individual patient was performed on the specific patient dossier of to report any potential psychotropic drug-drug interactions utilizing Medscape drug interaction checker for identification of the different types of drug-drug interactions. Result: The prevalence of potential drug-drug interaction at Psychiatry Unit in Sulaimani city in 60 patients was 98%, of which 16.6% were major drug-drug interactions. The most frequently prescribed medications were antidepressant drugs, most of patients received more than four drugs. Conclusion: From the current study one can conclude that there was a high prevalence of potential drug-drug interactions among psychiatric patients, which was more frequent in patients taking more than one psychotropic medication.

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Prevalence of potential drug interactions of clinical importance in primary health care and its associated factors / Prevalência de potenciais interações medicamentosas de importância clínica na atenção primária à saúde e seus fatores associados

Cited by 3 publications

References 0 publications

Nonagenarians in Hyperpolypharmacy: relationship between the level of drug interactions and sociodemographic, clinical, and functional characteristics

Nonagenarians in Hyperpolypharmacy: relationship between the level of drug interactions and sociodemographic, clinical, and functional characteristics

Promoting dental patient safety toward judicious medication usage: a review

Prevalence of Potential Drug-drug Interactions among Psychiatric Patients at Psychiatry Hospital in Sulaimani City

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