Prevalence of prediabetes, and diabetes in Chandigarh and Panchkula region based on glycated haemoglobin and Indian diabetes risk score

Kumar, Saurabh; Anand, Akshay; Nagarathna, Raghuram; Kaur, Navneet; Sivapuram, Madhava Sai; Pannu, Viraaj; Pal, Deepak Kumar; Malik, Neeru; Singh, Amit; Nagendra, Hongasandra Ramarao

doi:10.1002/edm2.162

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…After eliminating subjects with a history of consumption of antibiotics in the last 6–8 weeks, absence of paired duodenum/stool sample and low read sequencing depth (< 2000), 54 subjects with paired samples were finally analyzed. Based on the blood parameters; fasting plasma glucose (FPG; mg/dl), postprandial glucose (PPG; mg/dl) and glycated hemoglobin (HbA1c, %), subjects with FPG > 100 mg/dl and HbA1c ≥ 5.7%; were classified as hyperglycemic, while those with FPG ≤ 100 mg/dl and HbA1c < 5.7%; were classified as normoglycemic 58 . Overall, 33 established hyperglycemic and 21 normoglycemic were included in the study.…”

Section: Methodsmentioning

confidence: 99%

Hyperglycemia is associated with duodenal dysbiosis and altered duodenal microenvironment

Darra

Singh

Jena

et al. 2023

Sci Rep

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The gut microbiome influences the pathogenesis and course of metabolic disorders such as diabetes. While it is likely that duodenal mucosa associated microbiota contributes to the genesis and progression of increased blood sugar, including the pre-diabetic stage, it is much less studied than stool. We investigated paired stool and duodenal microbiota in subjects with hyperglycemia (HbA1c ≥ 5.7% and fasting plasma glucose > 100 mg/dl) compared to normoglycemic. We found patients with hyperglycemia (n = 33) had higher duodenal bacterial count (p = 0.008), increased pathobionts and reduction in beneficial flora compared to normoglycemic (n = 21). The microenvironment of duodenum was assessed by measuring oxygen saturation using T-Stat, serum inflammatory markers and zonulin for gut permeability. We observed that bacterial overload was correlated with increased serum zonulin (p = 0.061) and higher TNF-α (p = 0.054). Moreover, reduced oxygen saturation (p = 0.021) and a systemic proinflammatory state [increased total leukocyte count (p = 0.031) and reduced IL-10 (p = 0.015)] characterized the duodenum of hyperglycemic. Unlike stool flora, the variability in duodenal bacterial profile was associated with glycemic status and was predicted by bioinformatic analysis to adversely affect nutrient metabolism. Our findings offer new understanding of the compositional changes in the small intestine bacteria by identifying duodenal dysbiosis and altered local metabolism as potentially early events in hyperglycemia.

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Section: Methodsmentioning

confidence: 99%

Hyperglycemia is associated with duodenal dysbiosis and altered duodenal microenvironment

Darra

Singh

Jena

et al. 2023

Sci Rep

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“…Ramchandran et al reported 14% prevalence of prediabetes in the Indian population (19). Further, Kumar et al also revealed the prevalence of diabetes and prediabetes in a joint population of Chandigarh & Panchkula with 12.67% and 11.69% respectively (20). Moreover, in the Asian Indian population, the risk for conversion from prediabetic to a diabetic is more vulnerable in comparison with the other ethnic population groups (21)(22).…”

Section: Discussionmentioning

confidence: 98%

Confronting the potential role of Yoga in the molecular profile of rural high-risk women for Diabetes: a pilot study

Kaur¹,

Ahuja²,

Sharma³

et al. 2021

IMCR

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Background and purpose: Yoga has been shown to have established beneficial impact through many previous studies. The mind-body practices like Yoga have an ameliorating effect on diabetes and prediabetes. The majority of prior published literature focused their attention on the glucose parameters in diabetic and prediabetic pathology. The purpose of the present pilot study is to explore the effect of AYUSH-approved Diabetic Yoga Protocol (DYP) on selected angiogenesis and neurogenesis markers in high-risk rural women for Diabetes. Methods: Total 15 high-risk women for Diabetes were selected from rural area of Chandigarh, for a 3-month DYP intervention. The pre-post single group experimental research design was implemented in the study. The changes in angiogenesis, neurogenesis parameters, and leptin were assessed at baseline and after 3 months after DYP intervention. Results: The result of the present study revealed that after 3 months of DYP intervention the statistically significant improvements were noticed on serum VEGF levels (p = 0.039). The improvements in angiogenin and BDNF levels were also seen after DYP practice. Conclusion: The results highlight the potential role of DYP on cellular growth and neuronal survival. Keywords: Diabetic Yoga Protocol, Indian Diabetes Risk Score, Prediabetes, angiogenesis, neurogenesis.

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“…Whether the regulatory effect of yoga on HDL is mediated through a reverse cholesterol transport mechanism [ 43 ] that includes macrophage cholesterol efflux in arteries or an antioxidant or anti-inflammatory effect [ 44 , 45 , 46 ] mediated by NO promoting activity needs to be evaluated [ 43 ]. The increased number of diabetes cases in the Indian population creates a substantial economic burden [ 47 , 48 , 49 , 50 ] and poses a threat to having age-related disorders [ 51 , 52 , 53 ]. Therefore, the study may be extrapolated to other populations based on the varied acceptability of yoga protocol as its perceived benefits, barriers, and compliance may vary from one country to another.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial

et al. 2021

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Background: Dyslipidemia poses a high risk for cardiovascular disease and stroke in Type 2 diabetes (T2DM). There are no studies on the impact of a validated integrated yoga lifestyle protocol on lipid profiles in a high-risk diabetes population. Methods: Here, we report the results of lipid profile values of 11,254 (yoga 5932 and control 5322) adults (20–70 years) of both genders with high risk (≥60 on Indian diabetes risk score) for diabetes from a nationwide rural and urban community-based two group (yoga and conventional management) cluster randomized controlled trial. The yoga group practiced a validated integrated yoga lifestyle protocol (DYP) in nine day camps followed by daily one-hour practice. Biochemical profiling included glycated hemoglobin and lipid profiles before and after three months. Results: There was a significant difference between groups (p < 0.001 ANCOVA) with improved serum total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein in the yoga group compared to the control group. Further, the regulatory effect of yoga was noted with a significant decrease or increase in those with high or low values of lipids, respectively, with marginal or no change in those within the normal range. Conclusion: Yoga lifestyle improves and regulates (lowered if high, increased if low) the blood lipid levels in both genders of prediabetic and diabetic individuals in both rural and urban Indian communities.

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Prevalence of prediabetes, and diabetes in Chandigarh and Panchkula region based on glycated haemoglobin and Indian diabetes risk score

Cited by 7 publications

References 25 publications

Hyperglycemia is associated with duodenal dysbiosis and altered duodenal microenvironment

Hyperglycemia is associated with duodenal dysbiosis and altered duodenal microenvironment

Confronting the potential role of Yoga in the molecular profile of rural high-risk women for Diabetes: a pilot study

Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial

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