Prevalence of Primary &lt;i&gt;Helicobacter pylori&lt;/i&gt; Resistance to Several Antimicrobials in a Saudi Teaching Hospital

Eltahawy, A.T.A.E.

doi:10.1159/000058009

Cited by 19 publications

(19 citation statements)

References 19 publications

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“…However, we observed no resistance to TCN, consistent with reports from other countries [35][36][37][38], but in contrast to studies from India and Pakistan [39][40][41]. This difference may in part be attributed to different usage of this antibiotic in various countries.…”

Section: Discussionsupporting

confidence: 90%

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Aftab

Miftahussurur

Subsomwong

et al. 2016

J Infect Dev Ctries

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Introduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin in Bangladesh. Methodology: This study included 133 consecutive patients who underwent endoscopy examination at Dhaka Medical College in November 2014. The serial two-fold agar dilution method was used to determine the minimum inhibitory concentrations of the five antibiotics. Results: Among 56 cultured strains, H. pylori showed high rates of resistance to clarithromycin and metronidazole (39.3% and 94.6%, respectively). Moreover, levofloxacin showed an emerging antimicrobial resistance pattern (66.1%), which was higher in patients with gastritis than that in those with peptic ulcers (p = 0.02). The resistance rate of levofloxacin was significantly higher in patients living in Dhaka city compared to those living in the village (p = 0.049). However, amoxicillin and tetracycline resistance rates were very low. Resistance to both metronidazole and levofloxacin was most commonly observed. Conclusions: The rates of resistance to clarithromycin, metronidazole, and levofloxacin were high in Bangladesh, which suggests that triple therapy based on these drugs may not be useful as first-line therapies in Bangladesh. Alternative strategies such as furazolidone-based triple therapy, bismuth-based quadruple therapies, or sequential therapy may be more effective for patients in in Bangladesh.

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Section: Discussionsupporting

confidence: 90%

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Aftab

Miftahussurur

Subsomwong

et al. 2016

J Infect Dev Ctries

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“…In the present study, 56.3% of the H. pylori isolates were resistant to metronidazole, which was lower than the results obtained by Mohammadi et al (18). The rate of metronidazole resistance in Saudi Arabia (15) and China (17) was close to our study, which could be due to the regional distribution of resistance to antibiotics. The rate of resistance to tetracycline was around 15.6% in our study, while the rate of resistance to this antibiotic was no more than 5% in Italy (19), Saudi Arabia (15) and South Korea (16).…”

Section: Resultssupporting

confidence: 83%

“…The rate of metronidazole resistance in Saudi Arabia (15) and China (17) was close to our study, which could be due to the regional distribution of resistance to antibiotics. The rate of resistance to tetracycline was around 15.6% in our study, while the rate of resistance to this antibiotic was no more than 5% in Italy (19), Saudi Arabia (15) and South Korea (16). However, the rate of tetracycline resistance has been reported to be up to 50% in China (17).…”

Section: Resultssupporting

confidence: 83%

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Sikarchi

Fozouni

2018

mljgoums

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Background and Objectives: Helicobacter pylori is the most common cause of gastritis and ulcer worldwide. Treatment of such infections may lead to failure due to drug resistance. This study aimed to investigate the antimicrobial effects of bacteria present in camel milk on the growth of drug-resistant clinical isolates of H. pylori.Methods: In this cross-sectional study, biopsy samples from 75 patients with digestive symptoms were transferred to laboratory in transport medium containing homogeneous compounds. In order to isolate H. pylori, urease-positive biopsies were promptly cultured in brucella agar enriched with defibrinated sheep blood and fetal calf serum. Disk diffusion agar test was used to evaluate antibiotic susceptibility and agar well diffusion method was applied to study the antagonistic effect of probiotics isolated from camel milk on the H. pylori isolates.Results: The frequency of H. pylori isolates was 42.7%. The highest rate of resistance was observed against metronidazole (56.3%). In addition, the rate of resistant to amoxicillin, ciprofloxacin, and clarithromycin and tetracycline was 31.3%, 18.8%, 15.6%, respectively. Lactobacillus plantarum (59.3%) was more frequent than other Lactobacillus species. L. plantarum, Lactobacillus fermentum and Lactobacillus casei showed favorable inhibitory effects against the H. pylori isolates, but L. plantarum (with inhibition zone diameter of 20.3 mm) showed the highest inhibitory effect.Conclusion: Considering the increasing rate of drug resistance and the inhibitory effect of probiotics isolated from milk, health providers recommend that promoting consumption of probiotic food seems beneficial for the general population and those suffering from gastrointestinal disorders.

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“…In Iran, the resistance rate has been increasing, from 33% in 1997 to 76.8% in 2012 [13,14,[41][42][43][44]58] . The rate has also been rising from 38% to 78.5% over the past 20 years in Saudi Arabia [59][60][61][62] . Moreover, in 2 different studies, 42.6% and 63% of H. pylori strains were resistant to Metronidazole in 2012 in Turkey and United Arabia Emirates, respectively [63,64] .…”

Section: Therapymentioning

confidence: 99%

“…But when administering higher doses, some studies have reported optimal results even in case of high resistance to Metronidazole. Luther et al [66] reported 97.1% PP eradication rate with 2 wk of Omeprazole (20 mg BD), Bismuth sub- Iran [13] 1997-2000 70 DDM 1.4 33% 0% 1.4% Iran [14] 2001-2004 135 DDM 3.7 36.3% 0.7% 3.7% Iran [42] 2005 120 DDM 1.6 57.5% 0% 16.7% Iran [58] 2005 [110] 2013 153 DDM 7.2 63.8% -26.5% -Turkey [45] 2003 87 DDM ---27.5% Turkey [16] 2004 110 DDM ---48.2% Turkey [17] 2006 92 DDM ---40.5% Turkey [111] 2007 61 DDM ---16.4% Turkey [63] 2012 61 DDM 0 42.6% 0% 21.3% Levofloxain: 3.3% Lebanon [112] 2002 54 DDM 0 29.5% 2% 4% Bahrain [15] 1999 83 Epsilometer test -57% -33% Saudi Arabia [59,61] 1988 71 DDM -38% 1.4% -Saudi Arabia [59,61] 1996 62 DDM -85.5% 0% -Saudi Arabia [59] 1998 63 DDM -78.5% --Saudi Arabia [60] 2002 223 DDM 1.3 80% 0.4% 4% Saudi Arabia [62] 2008 46 DDM 0 69.5% -21% UAE [113] 2010 26 E-test ---19.2% UAE [64] 2013 16 ? -63% --Syria [114] 2012 ously during the entire duration of therapy.…”

Section: Therapymentioning

confidence: 99%

Helicobacter pylorieradication in West Asia: A review

Fakheri

Bari

Aarabi

et al. 2014

WJG

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The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. However, no review article has yet evaluated and compared the efficacy of different regimens among different countries of this region. Therefore, we conducted a review to select the best options and provide recommendations for H. pylori treatment in this geographic region. A search through PubMed was carried out to obtain relevant randomized clinical trials published in English language up to June 2013. According to the results, among different therapeutic regimens used as the first-line protocols, 10-d Bismuth-Furazolidone/Metronidazole quadruple therapy, 14-d Clarithromycin-containing hybrid therapy and 14-d quadruple therapy including a proton pump inhibitor + Bismuth + Tetracycline (500 mg QID) + Metronidazole (500 mg TDS) seemed to be appropriate options. Among second-line therapeutic regimens, Bismuthbased quadruple therapies containing Tetracycline and Furazolidone/Metronidazole, triple therapy containing Amoxicillin and Gatifloxacin and Quadruple therapy including Bismuth + Azithromycin and Ofloxacin seemed to be effective options. Third-line therapies were not evaluated in West Asia; most guidelines, however, recommend choosing optimal eradication regimen according to the pattern of antibiotic susceptibility of H. pylori . Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same. Core tip: The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. The present study evaluates and compares the efficacy of different regimens among different countries of this region. Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same.

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Prevalence of Primary <i>Helicobacter pylori</i> Resistance to Several Antimicrobials in a Saudi Teaching Hospital

Cited by 19 publications

References 19 publications

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Helicobacter pylorieradication in West Asia: A review

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