Prevalence of Pseudomonas aeruginosa and Acinetobacter spp producing metallo-β-lactamase in a tertiary care hospital

Rit, Kalidas; Chakraborty, Bipasa; Dey, Raja; Chakrabarty, Parthasarathi; Naha, Amrita; Saha, Rajdeep

doi:10.4103/2277-8632.108507

Cited by 4 publications

(2 citation statements)

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“…This higher infection cases in female patients may be due to poor nutrition, co-morbidity, malignancy, immunosuppression, and hematological disorders. 26 Our study is nearly similar to the study of Sharma et al in 34,9 Regarding Enterobacteriaceae, this is nearly similar to the study of Kaur et al in India and Diwakar et al in India. 28,35 But our study is nearly dissimilar to the study of Barai et al in Bangladesh and Pawar et al in India.…”

Section: Specimensupporting

confidence: 91%

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Phenotypic Detection of Carbapenemase-producing WHO-declared Deadliest Drug-resistant Bacteria in the Rajshahi Region

Haque

Alam²,

Kabir

et al. 2022

TAJ: J of Teachers Assoc

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Background: Carbapenem resistance is a major and ongoing public health problem globally and locally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Most of the carbapenemase-producing bacteria are multidrug resistant, including 3rd generation of cephalosporin and carbapenems. It may be intrinsic or mediated by transferable carbapenemase-encoding genes. This type of resistance gene is already widespread in certain parts of the world, mainly Europe, Asia, and South America. Objective: To isolate and identify WHO-declared carbapenemase-producing deadliest drug resistance bacteria with their antibiogram in the Rajshahi region. Materials Method: Cross sectional descriptive study was done from July 2017 to June 2018. Wound swab was collected in different surgical and burn units of Rajshahi Medical College Hospital. The specimens were inoculated in blood agar, nutrient agar, and MacConkey's agar media and incubated aerobically at 370 C for 24 hours. Susceptibility tests of the bacterial isolates were done by using the modified Kirby Bauer disk diffusion method on Mueller Hinton agar media. Carbapenemase-producing bacteria were identified by using the modified Hodge test. Results: Out of the total 250 samples, culture yielded growth in 213(85.2%) cases, and 37(14.8%) yielded no increase. Females were predominant 146(58.4%) in comparison to males 104(41.6%), with a male-female ratio of 1: 1.4. A maximum of 47.2% of cases were between 19-30 years old. Among the culture-positive isolates, gram-negative organisms were higher (58.8%) than gram-positive (41.2%). S. aureus was the predominant organism 71(30.8%), followed by P. aeruginosa 47(20.3%), E.coli 43(18.7%), and Acinetobacter baumannii 07 (3%). Among seven isolated Acinetobacter baumannii, 47 isolated P. aeruginosa, and 82 isolated Enterobacteriaceae: 6(85.7%), 33(70.2%), and 53(64.6%) were MDR; and 4(57.1%), 12(25.5%) and 14(17%) were carbapenemase-producers respectively. Conclusion: Most of the isolated carbapenemase-producing bacteria are multidrug resistant, and they tend to cause complicated infections. In addition, the expression of specific virulent factors, difficulty in diagnosis, and the non-availability of newer generation antibiotics make them one of the deadliest bacteria. TAJ 2022; 35: No-1: 91-98

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Section: Specimensupporting

confidence: 91%

“…India and Rajbahak et al in Nepal.43,38 . Our study is nearly dissimilar from the study of Khanamet al in Bangladesh and Kumari et al in India 25,26. .A maximum of 118 (47.2%) cases were found within the age group of 19-30 years.…”

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confidence: 94%