Prevalence of rheumatoid arthritis in Edmonton and Northern Alberta

Soo, Jason; Eldeiry, David; Katz, Steven J.

doi:10.1007/s10067-020-05352-5

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Smoking is the one of the environmental risk factors that doubles the risk of RA [6,7]. Other environmental risk factors include coffee consumption, vitamin D status, alcohol consumption, and poor socio-economic status, although there is no strong supporting evidence with respect to the influence of these factors [8,9]. There is also inadequate evidence regarding the role of dietary control in preventing RA [10].…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Temporomandibular Joint Disorder in Patients with Rheumatoid Arthritis: A Longitudinal Follow-Up Study

Byun

Min

Choi

2020

JCM

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We evaluated the incidence of temporomandibular disorder (TMD) in patients with rheumatoid arthritis (RA) and examined the association between TMD and RA, through longitudinal follow-up. Population data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 was used. From 514,866 subjects, 3122 with RA were matched with 12,488 controls in a 1:4 ratio. The crude and adjusted models (for obesity, smoking, alcohol consumption, blood pressure, blood glucose, total cholesterol, and Charlson Comorbidity Index scores) were calculated. Chi-square tests, Kaplan-Meier (KM) analysis, and two-tailed analyses were used for statistical analysis. Stratified Cox proportional hazard models were used to assess the hazard ratios (HR) and 95% confidence intervals (CI) for TMD in the RA group, compared to those in the control group. The adjusted HR for TMD in RA was 2.52 (95% CI = 1.70–3.74), compared to the control group. The results were consistent with the subgroup analyses, according to age and sex, except in men older than 60 years of age. KM analysis showed similar results. Hence, we found that patients with RA have a higher risk of TMD, and should be observed for symptoms of the initial stage of TMD to prevent the risk of aggravation.

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Section: Introductionmentioning

confidence: 99%

Increased Risk of Temporomandibular Joint Disorder in Patients with Rheumatoid Arthritis: A Longitudinal Follow-Up Study

Byun

Min

Choi

2020

JCM

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Triptolide alters intestinal bacteria and ameliorates progression of rheumatoid arthritis in mice

Pan,

Jin,

Chen

et al. 2024

Preprint

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Background Triptolide is a natural compound with immunosuppressive properties. Triptolide has used as a traditional Chinese medicine to treat rheumatoid arthritis (RA). We explore the effects of triptolide on intestinal bacteria and its potential role in alleviating RA progression in mice. Methods We randomly assigned thirty-six mice to six of the following groups: Con group, adjuvant-induced arthritis (AIA) group, Htrip group, Mtrip group, Ltrip group and Cele group. We collected tissue and blood samples as well as peritoneal macrophages to assess the effects of triptolide on the response to AIA through physical examinations, ELISA and PCR. We used 16S rDNA gene sequencing to analyze the intestinal flora of AIA mice treated with triptolide. Western blot was used to identify the potential influences on the TLR4/NF-κB pathway, ZO-1 and Occludin. Results Our findings showed that triptolide led to a significant reduction in the arthritic index score and paw swelling. It also improved intestinal barrier function by upregulating ZO-1 and Occludin. Furthermore, triptolide treatment caused changes in the intestinal flora by increasing the abundance of beneficial bacteria while decreasing harmful bacteria. Finally, our study demonstrated that triptolide inhibited TLR4/NF-κB, which contributed to its suppressive effects on inflammation. Conclusion In summary, our results suggest that triptolide can significantly alleviate the inflammatory response in AIA mice and, at the same time, promote recovery of intestinal barriers. Its mechanism may potentially be mediated by the intestinal flora through the TLR4/NF-κB pathway.

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Prevalence of rheumatoid arthritis in Edmonton and Northern Alberta

Cited by 2 publications

References 6 publications

Increased Risk of Temporomandibular Joint Disorder in Patients with Rheumatoid Arthritis: A Longitudinal Follow-Up Study

Increased Risk of Temporomandibular Joint Disorder in Patients with Rheumatoid Arthritis: A Longitudinal Follow-Up Study

Triptolide alters intestinal bacteria and ameliorates progression of rheumatoid arthritis in mice

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