Prevalence of sarcopenia among healthy ambulatory subjects: the sarcopenia begins from 45 years

Chérìn, P.; Voronska, Elena; Fraoucene, N.; Jaeger, Christophe

doi:10.1007/s40520-013-0132-8

Cited by 74 publications

(64 citation statements)

References 57 publications

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“…Clearly, the current proportions overshadow the prevalence in South Korea, but the latter was reported in a relatively healthy population, as individuals admitted to hospital or nursing homes were not included. The higher prevalence of sarcopenia in COPD than in the healthy elderly (based on available literature [10]) reflects the suggested accelerated ageing in COPD, which is further supported by the reported shorter telomere length in COPD patients [18]. Potential catabolic triggers for inducing the sarcopenic process in COPD include physical inactivity, oxidative stress, inflammation, use of glucocorticosteroids and hypoxia [19].…”

Section: Discussionmentioning

confidence: 85%

“…An appendicular skeletal muscle mass index (ASMI) of ⩾2 standard deviations below the mean of healthy persons between 20 and 30 years of age of the same ethnic group is nowadays commonly used to define sarcopenia in the elderly [9]. In the general well-functioning aged population, sarcopenia according to this definition is prevalent in ∼15% [10], but only sparse data are available in COPD. In a non-institutionalised civilian population of South Korea, sarcopenia was found in 32.8% of male and 12.2% of female COPD patients [11].…”

Section: Introductionmentioning

confidence: 99%

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Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

et al. 2015

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Decreased physical performance due to loss of muscle mass (i.e. sarcopenia) is prevalent in ageing and appears more pronounced in chronic disease. A comprehensive profile of the sarcopenic phenotype in chronic obstructive pulmonary disease (COPD) is not yet available. The aim of the present study was to characterise prevalence, functional implications and predictive value of sarcopenia with or without abdominal obesity in Dutch COPD patients eligible for pulmonary rehabilitation.505 COPD patients (aged 37-87 years; 57% male) underwent assessment of lung function, body composition and physical functioning, before entering pulmonary rehabilitation. Sarcopenia was assessed by appendicular skeletal muscle index (ASMI) and abdominal obesity by android/gynoid percentage fat mass (A/G%FM) using dual energy X-ray absorptiometry.86.5% of patients were sarcopenic and showed lower physical functioning, while coexistent abdominal obesity (78.0%) resulted in higher physical functioning. Implications on endurance were less pronounced in women. The predictive value for physical functioning was higher for the "three-compartment" model (ASMI, bone mineral content and A/G%FM) than the "two-compartment" model (fat-free mass index and fat mass index) or "one-compartment" model (body mass index).In patients eligible for pulmonary rehabilitation, sarcopenia is highly prevalent in all body mass index categories and associated with impaired strength, and in men also with decreased endurance. Abdominal obesity seems to have protective effects on physical functioning. ASMI is a better predictor for physical functioning than fat-free mass index. @ERSpublications Highly prevalent sarcopenia and abdominal obesity in COPD patients exert antagonistic effects on physical functioning http://ow.ly/L5b9r

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

et al. 2015

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“…Possible explanations were listed as below: first, diabetic patients with overweight may have early screening of metabolic disorder and accept early treatment for the prevention for serious CVD complications, which may decrease the risk of all-cause mortality. Second, excess body mass may provide a metabolic reserve in older patients, protecting against frailty, malnutrition, and age-related sarcopenia (30,31).…”

Section: Discussionmentioning

confidence: 99%

Association of body mass index with all-cause mortality in patients with diabetes: a systemic review and meta-analysis

Chang

Hsieh

et al. 2016

Cardiovasc. Diagn. Ther.

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Background: The obesity paradox phenomenon has been found in different populations, such as heart failure and coronary heart disease, which suggest that patients with established cardiovascular disease (CVD) and with normal weight had higher risk of mortality than those with overweight or obesity. However, the obesity paradox is controversial among patients with diabetes which has been considered as the coronary heart disease equivalent. The aim of our study was to summarize current findings on the relationship between body mass index (BMI) and all-cause mortality in patients with diabetes and make a meta-analysis. Methods:We searched previous studies from MEDLINE, EMBASE, and the Cochrane databases using the keywords: BMI, mortality, diabetes, and obesity paradox or reverse epidemiology. Finally, sixteen studies were identified and 385,925 patients were included. Patients were divided into five groups based on BMI (kg/m 2 ) levels: underweight (<18.5), normal weight (18.5-24.9), overweight (25-29.9), mild obesity (30-34.9), and morbid obesity (>35). A random effect meta-analysis was performed by the inverse variance method.Results: As compared with the normal weight, the underweight had higher risk of mortality [hazard ratio (HR): 1.59, 95% confidence interval (CI): 1.32-1.91]. In contrast, the overweight and the mild obesity had lower risk of mortality than the normal weight (HR: 0.86, 95% CI: 0.78-0.96, and 0.88, 95% CI: 0.78-1.00, respectively), but the morbid obesity did not (HR: 0.99, 95% CI: 0.84-1.16). In addition, the subgroup analysis by sex showed that the overweight had the lowest mortality as compared with the normal weight (HR: 0.82, 95% CI: 0.74-0.90) and the obesity in males, but the risk of mortality did not differ among groups in females. Notably, the heterogeneity was significant in most of group comparisons.Conclusions: Our meta-analysis showed a U-shaped relationship between BMI and all-cause mortality in patients with diabetes. The significant heterogeneity among studies suggested that many confounders such as sex difference may affect the association.

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“…Whereas low muscle mass is prevalent in ±15% of well‐functioning elderly in the general aged population,26 a higher prevalence can be expected in COPD as a reflection of accelerated ageing 25. Indeed, Van de Bool et al .…”

Section: Recent Developments In Identifying Muscle Wasting In Copdmentioning

confidence: 99%

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Sanders¹,

Kneppers²,

Bool³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

119

101

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Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD‐induced cachexia.

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Prevalence of sarcopenia among healthy ambulatory subjects: the sarcopenia begins from 45 years

Cited by 74 publications

References 57 publications

Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

Association of body mass index with all-cause mortality in patients with diabetes: a systemic review and meta-analysis

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

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