BackgroundConsidering medical and economic burden of the coronavirus disease 2019 (COVID-19), a high COVID-19 vaccination coverage among health care workers (HCWs) is an urgent need.ObjectiveTo estimate the intention of HCWs to accept COVID-19 vaccination and to find out related factors.DesignWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines for this study.Data sourcesWe searched PubMed, Medline, Scopus, Web of Science, ProQuest, CINAHL and medRxiv from January 1, 2020 to December 02, 2020.MethodsThe heterogeneity between results was very high and thus we applied a random effect model to estimate pooled effects. We performed subgroup and meta-regression analysis to identify possible resources of heterogeneity.ResultsEleven studies, including 8847 HCWs met the inclusion criteria. The overall proportion of HCWs that intent to accept COVID-19 vaccination was 55.9% (95% CI: 43.6-67.9%) with a wide range among studies from 27.7% to 81.5%. Intention of HCWs to accept COVID-19 vaccination was higher in studies with moderate quality and in studies that were conducted in Europe. The following factors were associated with increased HCWs’ willingness to get vaccinated against COVID-19: male gender, older age, physician profession, fewer work experience, comorbidity among HCWs, seasonal influenza vaccination, stronger vaccine confidence, positive attitude towards a COVID-19 vaccine, fear about COVID-19, individual perceived risk about COVID-19, and contact with suspected or confirmed COVID-19 patients.ConclusionsHCWs represent a high-risk group for SARS-CoV-2 infection. The reluctance or refusal of HCWs to vaccinate against COVID-19 could diminish the trust of individuals and trigger a ripple effect in the general public. Since vaccination is a complex behavior, understanding the way that HCWs take the decision to accept or not COVID-19 vaccination will give us the opportunity to develop the appropriate interventions to increase COVID-19 vaccination uptake. Knowledge of the factors that affect intention of HWCs to accept COVID-19 vaccination is limited and there is an urgent need for further and more valid studies.