Background: The main objective of this study was addressing the prevalence of self-medication, its causes, sources of information and medications in Ibb city, the Republic of Yemen. Methods: This study followed a survey-study method where the data was collected using a self-administrated questionnaire with stratified random sampling and simple random sampling procedures to select the study samples. A sample of 500 patients from the three major hospitals at Ibb city (AL-Thawrah, Nasser and Motherhood hospitals) were selected in this study. Both descriptive and referential analyses were used to answer the raised research questions. Results: The results indicated that 85% of the participants practiced self-medication in the last three months prior to data collection. The most reason reported for self-medication is that the drug supply in hospitals was unavailable. The most source of information about self-medication reported by respondents was pharmacists and the most source of medication was private pharmacies. Besides, more than half of the participants indicated prior knowledge regarding the dangers of self-medication. Chi-square analysis indicated that respondents who are urban, married and older than 40 years are more likely to practice self-medication. Conclusions: Educational campaigns and strict legislation measures relating to drugs dispensing from private pharmacies, supplying the governmental hospitals with the medications and facilitate access to health care services are among the necessary intervention(s) that may modify the behavior of individuals and protect them from potential dangers of self-medication.