Prevalence of SEN virus among children in Japan

Sugiura, Tetsuro; Goto, Kenji; Imamine, Hiroki; Ando, Tsutomu; Ban, Kyoko; Sugiyama, Kohachiro; Togari, Hajime

doi:10.1016/j.virusres.2003.12.028

Cited by 9 publications

(14 citation statements)

References 26 publications

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“…According to another study among volunteer blood donors [15] and patients on maintenance hemodialysis in adults in Taiwan showing the same prevalence rate as in children, infection may occur at an early age. Mother-to-infant transmission of the virus through the placenta is a highly possible route of transmission [18]. In this study, the rates of SENV-D and SENV-H infection among the blood transfusion group were significantly higher than those among the control group.…”

Section: Discussionmentioning

confidence: 54%

“…This suggests that blood transfusion is another major transmission route of SENV-D or SENV-H infection in children. One report mentions that the difference in SENV-D or SENV-H infection rates was not statistically significant in the blood transfusion group and control group in children [18]. The blood transfusion children group only received a few transfusions in that study.…”

Section: Discussionmentioning

confidence: 94%

“…Umemura et al[ 6] reported an association between two SENV variants (SENV-D and SENV-H) and transfusion-associated non-A to E hepatitis in Japanese patients. Another report, Sugiura et al[ 18], in Japan reported that the two variants are not associated with acute or chronic hepatitis, although SENV-D might be a risk factor of fulminant hepatitis. Nevertheless, other studies have found only a weak association between SENV infection and liver disease [19,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…The observed low frequency of hepatitis among SENV-infected patients does not negate the possibility that SENV is the responsible agent in other patients. Levels of viremia tend to parallel the level of ALT [18], so SENV quantification might offer another assessment for clinical disease severity. We do not know the long-term complications for patients carrying the SENV.…”

Section: Discussionmentioning

confidence: 99%

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SEN and Hepatitis Virus Infections in Nontransfused Children and Pediatric Thalassemia Patients with Multiple Transfusions in Taiwan

Chiou

Huang²,

Chang³

et al. 2006

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Background: SouthernTaiwan is a hepatitis B and C viruses (HBV, HCV) endemic area. SEN virus (SENV) infection has been suggested as transfusion-related hepatitis. Two variants of SENV (SENV-D and SENV-H) have been studied in non-transfused children and transfusion-dependent thalassemia patients. Methods: Sera of 67 non-transfused children and 55 pediatric thalassemia patients with multiple transfusions were tested for SENV-D and SENV-H DNAs, liver function, iron status, HBV and HCV markers. Results: The prevalence of SENV (D or H), SENV-D, SENV-H infection, and SENV-D/H coinfection was significantly lower in nontransfused children than in thalassemia patients (22.4, 20.9, 5.0 and 1.5%, respectively, versus 67.3, 52.7, 40.0 and 25.5%, respectively, p < 0.001). The serum alanine aminotransferase (ALT) levels in thalassemia patients with SENV infection alone were significantly lower than levels in patients with SENV/HCV co-infection (p < 0.05), but not different when compared with those without SENV/HCV infection. SENV viremia was not associated with elevated ALT levels in thalassemia patients. SENV viremia did not increase the risk of HCV infection in thalassemia patients. Conclusions: SENV infection is high among non-transfused controls in Taiwan. Transfusion significantly increases the relevance of SENV infection. SENV viremia was not associated with the ALT levels in thalassemia patients.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

SEN and Hepatitis Virus Infections in Nontransfused Children and Pediatric Thalassemia Patients with Multiple Transfusions in Taiwan

Chiou

Huang²,

Chang³

et al. 2006

Digestion

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“…The SEN virus (SENV) was considered to be a member of the family Circoviridae, genus Anellovirus, a group of non-enveloped, circular DNA viruses that also included the Torque teno (TTV) and its variants SANBAN, YONBAN, TUS01, and PMV (Sugiura et al, 2004). Now Anelloviridae is a highly divergent family of viruses that has three genera of anelloviruses capable of infecting humans: torque teno virus (TTV; Alphatorquevirus), torque teno minivirus (TTMV; Betatorquevirus), and torque teno midivirus (TTMDV; Gammatorquevirus) (Biagini, 2009).…”

Section: Introductionmentioning

confidence: 99%

Does SEN virus (SENV) infection affect the progression of chronic hepatitis C or B among Egyptian patients?

Elsherbiny¹,

Hassan²,

Ahmed³

et al. 2015

Afr. J. Microbiol. Res.

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The effect of SENV infection on chronic viral hepatitis is not very clear till now. Information regarding SENV infections in the Egyptian population where hepatitis viruses are prevalent is limited to a certain extent. We aimed to determine the frequency of SENV and its genotypes H and D in Egyptian patients with chronic hepatitis B (CHB) or C (CHC) and to study its possible role in the progression of liver disease. A total of 112 patients with chronic hepatitis (18 CHB and 94 CHC) were subjected to clinical assessment, laboratory and histological examinations. DNA from sera was extracted and SENV DNA was amplified by polymerase chain reaction. SENV DNA was detected in 28.6% of patients with chronic hepatitis (32/112). The percentage was 33.3 and 27.7% in CHB and CHC patients respectively. SENV-H was detected more frequently than SENV-D genotype. For CHC patients without cirrhosis (n=44), SENV was negative in 90.9% (40/44) compared to 9.1% (4/44) SENV positive giving a statistically significant difference (<0.001). A significantly higher percentage of patients showed twofold or more increase in the aspartate transaminase (AST) and alkaline phosphatase (ALP) among SENV negative CHC patients compared to SENV positive patients (P=0.04 , 0.03 respectively). In cirrhotic patients (n=58), both the levels of ALP and serum total bilirubin were significantly higher in SENV negative compared to SENV positive patients (P values were 0.01). For CHB patients, no statistically significant difference was detected regarding any of the studied parameters. We conclude that SENV does not worsen the progression of chronic viral hepatitis. This may reflect a possible protective effect of SENV in CHC patients which needs to be emphasized by further larger studies.

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