Prevalence of Sensitivity to Food and Drug Additives in Patients With Chronic Idiopathic Urticaria

Rajan, Jessica; Simon, Ronald A.; Bosso, John V.

doi:10.1016/j.jaip.2013.10.002

Cited by 61 publications

(53 citation statements)

References 10 publications

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“…However, a recent study yielded only two positive results from a single-blind challenge with 11 food additives of each of 100 patients with chronic urticaria. Moreover, when a double-blind test and a placebo challenge test were performed on these two positive patients, neither reacted to the culprit additive [31]. Avoidance of food preservatives and additives is not therefore recommended.…”

Section: Resultsmentioning

confidence: 99%

Management of urticaria: not too complicated, not too simple

Ferrer

Bartra

Giménez‐Arnau

et al. 2015

Clin Experimental Allergy

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In spite of being an old disease and apparently easy to diagnose, chronic spontaneous urticaria (CSU) is still perceived as an uncontrollable and difficult to manage disease. The perception of the patient is that his/her condition is not well understood and that is suffering from a disorder with hidden causes that doctors are not able to tackle. Sometimes patients go through a number of clinicians until they found some CSU expert who is familiar with the disease. It is surprising that myths and believes with no scientific support still persist. Guidelines are not widely implemented, and recent tools to assess severity are infrequently used. European and American recent guidelines do not agree in several key points related to diagnosis and treatment, which further contributes to confusion. With the aim to clarify some aspects of the CSU picture, a group of allergists and dermatologists from the Spanish Dermatology and Allergy societies developed a Frequent Asked Questions leaflet that could facilitate physicians work in daily practice and contribute to a better knowledge of common clinical scenarios related to patients with CSU.

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Section: Resultsmentioning

confidence: 99%

Management of urticaria: not too complicated, not too simple

Ferrer

Bartra

Giménez‐Arnau

et al. 2015

Clin Experimental Allergy

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“…168 The most recent study, using semi-quantitative skin scores as the end point, concluded the prevalence of food additive sensitivity in CIU patients occurs rarely if at all. 169 These include challenges with monosodium glutamate (MSG), benzoates, parabens, sulfites, butylated hydroxyanisole/butylated hydroxytoluene (BHA/BHT), tartrazine (FD&C Yellow #5, E102), Sunset yellow (FD&C Yellow #6, E110), and aspartame (Nutrasweet).…”

Section: Section V: Adverse Reactions To Food Additivesmentioning

confidence: 99%

“…168,169 Summary Statement 17: Do not routinely instruct asthmatic patients to avoid sulfites or other food additives unless they have a prior reaction to sulfites. Sulfites are the only food additive proved to trigger asthma.…”

Section: Section V: Adverse Reactions To Food Additivesmentioning

confidence: 99%

Food allergy: A practice parameter update—2014

Bernstein¹,

Blessing-Moore²,

Khan³

et al. 2014

Journal of Allergy and Clinical Immunology

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725

564

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“…30 On day 1, the patient receives a placebo to determine baseline activity, and on day 2, the patient receives escalating doses of ASA (71,117,312, and 500 mg) at 1.5-to 2-hour intervals. 31 Most patients will react to a single dose of aspirin between 325 and 650 mg, with at least 1 hour to react after ingestion of aspirin. There is no role for skin testing in the diagnosis of NECD.…”

Section: Clinical Presentationmentioning

confidence: 99%

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema

Kowalski

Woessner

Sanak

2015

Journal of Allergy and Clinical Immunology

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Nonsteroidal anti-inflammatory drug (NSAID)-induced urticarial and angioedema reactions are among the most commonly encountered drug hypersensitivity reactions in clinical practice. Three major clinical phenotypes of NSAID-induced acute skin reactions manifesting with angioedema, urticaria, or both have been distinguished: NSAID-exacerbated cutaneous disease, nonsteroidal anti-inflammatory drug-induced urticaria/angioedema (NIUA), and single NSAID-induced urticaria and angioedema. In some patients clinical history alone might be sufficient to establish the diagnosis of a specific type of NSAID hypersensitivity, whereas in other cases oral provocation challenges are necessary to confirm the diagnosis. Moreover, classification of the type of cutaneous reaction is critical for proper management. For example, in patients with single NSAID-induced reactions, chemically nonrelated COX-1 inhibitors can be safely used. However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA. In this review we present a practical clinical approach to the patient with NSAID-induced urticaria and angioedema.

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Prevalence of Sensitivity to Food and Drug Additives in Patients With Chronic Idiopathic Urticaria

Cited by 61 publications

References 10 publications

Management of urticaria: not too complicated, not too simple

Management of urticaria: not too complicated, not too simple

Food allergy: A practice parameter update—2014

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema

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