Prevalence of serum autoantibodies and paraproteins in patients with glaucoma

Hammam, Tarek; Montgomery, Donald; Morris, Delia F.; Imrie, Fraser

doi:10.1038/sj.eye.6702613

Cited by 24 publications

(23 citation statements)

References 15 publications

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“…In a later study, Hammam et al confirmed higher serum concentrations of just IgA in patients with NTG, compared to POAG patients and controls [11]. Our results do not confirm those findings.…”

Section: Discussioncontrasting

confidence: 94%

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Selected autoantibodies and normal-tension glaucoma

Jamrozy−Witkowska

2014

Med Sci Monit

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BackgroundAlthough intraocular pressure is an important risk factor in glaucoma, there is growing body evidence indicating an immunological component in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to determine if NTG coexists with elevated levels of autoantibodies detected in rheumatic diseases.Material/MethodsWe enrolled 105 patients into the study: 35 with NTG, 34 with primary open-angle glaucoma (POAG), and 36 controls. All patients underwent ophthalmic examination and blood tests. Blood was examined for the level of: antibodies against antinuclear antibodies (ANA), antibodies to extractable nuclear antigens (ENA), immunoglobulins (IgG, IgA, IgM), rheumatoid factor, anti-citrullinated protein antibodies (ACPA), and antiphospholipid antibodies (anticardiolipin antibodies, beta2-glycoprotein I antibodies, antiprothrombin antibodies).ResultsThe level of ANA was increased among 6 patients in the NTG group (17.1%), 8 in the POAG group (23.5%), and 6 in the control group (16.5%). The difference was not statistically significant (p=0.97). None of the patients in the NTG, POAG, or control group had positive antibodies to ENA. The level of immunoglobulins IgG, IgM, and IgA in the 3 groups was similar and within normal values. The median level of rheumatoid factor and ACPA was the highest in the NTG group, but it was within normal laboratory values. There was a statistically significant difference between antiprothrombin antibodies IgG between the NTG and POAG group (p=0.01), but not between the NTG and control group (p=0.24).ConclusionsThe results of our study do not confirm the hypothesis that NTG coexists with elevated blood levels of antibodies, which are a characteristic feature of rheumatic diseases.

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Section: Discussioncontrasting

confidence: 94%

“…Compared with the other groups, the NTG patients had statistically significant increases in serum IgA levels and considerably higher ANA levels, although the latter difference was not statistically significant [11]. …”

Section: Introductionmentioning

confidence: 99%

Selected autoantibodies and normal-tension glaucoma

Jamrozy−Witkowska

2014

Med Sci Monit

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“…In this context, greater prevalence of monoclonal gammapathy has been observed in glaucoma patients, together with higher autoantibody levels in the serum and in the aqueous humor, deposition of immunoglobulins and plasma cells in the retina (Gramlich et al, 2013;Hammam et al, 2008;PinazoDuran et al, 2013;Wax et al, 1998), and chronic activation of resident immunoregulatory glial cells and complement activation (Tezel and The Fourth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group, 2009). Similar to other autoimmune disorders, a serum alteration of the populations of T-cell repertoires and of interleukin-2 receptors has been detected (Yang et al, 2001a).…”

Section: Mechanisms Responsible For Contralateral Eye Involvementmentioning

confidence: 99%

Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes

Ramírez

Salazar

Hoz

et al. 2015

Progress in Brain Research

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“…Some possible risk factors to consider may be neuronal excitotoxicity (21), inflammation (22), genetic predisposition (23)(24)(25)(26), autoimmunity (27) and retinal circulation disturbance (28,29). Among them, we believe that retinal circulation disturbance may be the most likely candidate because there is evidence that radiation induces poor choroidal circulation 30 or 45 years after exposure (30), and that retinal arteriolosclerosis in A-bomb survivors is significantly associated with A-bomb radiation 55 years after exposure (31).…”

Section: Discussionmentioning

confidence: 99%

Glaucoma in Atomic Bomb Survivors

et al. 2013

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Radiation has been associated with increases in noncancerous diseases. An effect of low-dose radiation on the prevalence of clinically detected glaucoma has not been previously reported. We therefore investigated the prevalence of glaucoma in A-bomb survivors and its possible association with radiation dose. A total of 1,589 people who participated in the clinical examination program for A-bomb survivors at the Radiation Effects Research Foundation (RERF) between October 2006 and September 2008 and who had reconstructed radiation doses, were recruited into this cross-sectional screening study. The prevalence of glaucoma and its dose-response relationship to A-bomb radiation were measured. Each subject underwent an initial screening consisting of an interview and ophthalmological examination. Questionable cases with any indication of ocular disease, including glaucoma, were referred to local hospitals for more comprehensive evaluation. A diagnosis of glaucoma was made based on specific optic disc appearance, perimetric results and other ocular findings. Of 1,589 eligible people, we detected 284 (17.9%) cases of glaucoma overall, including 36 (2.3%) cases of primary open-angle glaucoma with intraocular pressure levels greater than 21 mmHg, 226 (14.2%) cases of normal-tension glaucoma and 25 (1.6%) cases of primary angle-closure glaucoma. Seven glaucoma risk factors were examined as potential confounders but only two needed to be included in the final model. Binary regression using a generalized estimating equation method, with adjustment for gender, age, city, cataract surgery or diabetes mellitus, revealed an odds ratio at 1 Gy of 1.31 (95% confidence interval 1.11-1.53, P = 0.001) in the case of normal-tension glaucoma, but no association for other types of glaucoma. The prevalence of normal-tension glaucoma may increase with A-bomb radiation dose, but uncertainties associated with nonparticipation (59% participation) suggest caution in the interpretation of these results until they are confirmed by other studies.

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Prevalence of serum autoantibodies and paraproteins in patients with glaucoma

Cited by 24 publications

References 15 publications

Selected autoantibodies and normal-tension glaucoma

Selected autoantibodies and normal-tension glaucoma

Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes

Glaucoma in Atomic Bomb Survivors

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