Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism

Rf, Nachreiner; Refsal, Kent R.; Graham, Peter; Bowman, Mark M.

doi:10.2460/javma.2002.220.466

Cited by 150 publications

(83 citation statements)

References 11 publications

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“…Lymphocytic thyroiditis is known to be highly heritable, and an influence of breed on age and progression of this disease has been demonstrated. 16,17 Dogs that were positive or inconclusive for TgAA (but had normal T4, FT4, and TSH concentrations) were not excluded from the analyses reported in our study because mean T4, FT4, and TSH concentrations were not different from those determined for TgAA-negative dogs, and their removal did not significantly change the results. These results agree with a study of human subjects where it was determined that there was minimal influence of antithyroid antibodies on the TSH reference range.…”

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confidence: 96%

“…These autoantibodies can interfere with the immunological measurement method and result in falsely elevated T4 concentration. 17 In our study, T4AA and T3AA were not measured. However, previously, it has been demonstrated that the presence of T4AA and T3AA did not result in falsely elevated thyroid hormone results when the chemiluminescence immunoassay b utilized in the current report was used.…”

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confidence: 99%

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Breed-specific reference intervals for assessing thyroid function in seven dog breeds

et al. 2015

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Abstract. Thyroxine (T4), free T4 (FT4), and thyrotropin (TSH) concentrations were measured in serum from 693 healthy representatives from 7 dog breeds (Alaskan Malamute, Collie, English Setter, Golden Retriever, Keeshond, Samoyed, or Siberian Husky) to determine whether breed-specific reference intervals (RIs) are warranted. Veterinarians reviewed the health history, performed a physical examination, and approved laboratory data for the enrolled dogs. Many purebred dogs had T4 and FT4 concentrations that were at, or below, the lower limits previously determined for non-breed-specific RIs. Median TSH values ranged from 6.10 mIU/L (0.07 ng/mL; Alaskan Malamute and Golden Retriever) to 17.6 mIU/L (0.26 ng/mL; Collie). Mean T4 and FT4 concentrations were higher in females. Increasing age was associated with decreasing T4 and FT4, and increasing TSH concentration. The substantial ranges across breeds of measures of central tendency (mean, median) for all hormones indicate that breed-specific RIs are warranted. RIs encompassing the central 95% of reference values for all breeds combined, and for individual breeds, were calculated using nonparametric (TSH) and robust (T4, FT4) methods. Use of breed-specific RIs in combination with careful attention to the potential for preanalytical and analytical variability in test results will improve thyroid function assessment in these breeds.

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confidence: 96%

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confidence: 99%

Breed-specific reference intervals for assessing thyroid function in seven dog breeds

et al. 2015

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“…Although once daily dosing results in more fluctuation in serum T 4 concentrations compared to twice daily dosing, the duration of action of T 4 is longer than its plasma half‐life 22, 23, 24, 25, 26. In previous studies of the HPTA, dogs were administered levothyroxine twice daily, making comparisons difficult 6, 14…”

Section: Discussionmentioning

confidence: 99%

Effects of Levothyroxine Administration and Withdrawal on the Hypothalamic‐Pituitary‐Thyroid Axis in Euthyroid Dogs

Ziglioli

Panciera

Troy

et al. 2017

Veterinary Internal Medicne

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BackgroundChronic supplementation can suppress the hypothalamic‐pituitary‐thyroid axis (HPTA) and make it difficult to assess thyroid function after withdrawal of levothyroxine.ObjectivesTo determine whether the HPTA is suppressed after levothyroxine administration in euthyroid dogs and the time required for resolution of any suppression.AnimalsTwenty‐eight healthy euthyroid dogs.MethodsA prospective, randomized study administering levothyroxine to euthyroid dogs for 8 weeks (group 1) or 16 weeks (group 2). Serum concentrations of total thyroxine (T4), free thyroxine (fT 4) by equilibrium dialysis, thyroid stimulating hormone; thyrotropin (TSH), and 3,5,3′‐triiodothyronine (T3) were measured every 4 weeks during supplementation and for 16 weeks after levothyroxine was discontinued.ResultsMean serum concentrations of T4 and fT 4 were significantly higher (P < .0001) and TSH was lower (P < .0001) in all dogs during levothyroxine administration compared to baseline. Mean serum concentrations of T4, fT 4, and TSH in both groups, beginning 1 week after levothyroxine was discontinued, were significantly different (P < .01) compared to values during levothyroxine administration but not compared to baseline values (P > .3).Conclusions and Clinical ImportanceAssessing thyroid function tests 1 week after cessation of levothyroxine at 26 μg/kg once a day for up to 16 weeks will provide an accurate assessment of thyroid function in healthy euthyroid dogs.

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“…Only 17% of serum samples showed the presence of TPOAB, thus the parameter cannot be used for diagnosing lymphocytic thyroiditis in dogs. The presence of antibodies against thyroid hormones was tested, among others, by Nachreiner et al (18). The authors observed T3 and T4 antibodies in 6.3% of the tested dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Only when the animal has characteristic clinical symptoms, which can be assessed during clinical examination, and the remaining results of laboratory tests confirm the suspicion of the thyroid disease, TgAb s identification can be the basis for diagnosing hypothyroidism caused by lymphocytic thyroiditis. As a genetic susceptibility to lymphocytic thyroiditis has been described, it seems rational to perform such tests in breeding dogs (2,18,21). It also seems to be advisable to propose the owners of dogs used in breeding programmes, especially of breeds considered to be prone to hypothyroidism, to carry out prophylactic screening tests aiming at selecting animals with the TgAb s .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of measuring the concentration of thyroglobulin antibodies in serum of dogs for the assessment of thyroid functioning

Popiel

Cekiera

2014

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to estimate the usefulness of measuring the thyroglobulin antibodies (TgAb s ) concentration in dogs' serum in order to assess thyroid functioning. The study was performed on 383 dogs. The animals were divided into two groups: group A (n = 308) consisted of dogs with hypothyroidism and group B (n = 75) consisted of dogs with euthyreosis. TgAb s was determined in both groups. The reaction to the TgAb s in group A was strongly positive in 32% of dogs, weakly positive in 33% of dogs, and negative in 35% of dogs. The TgAb s were observed in 32% of the dogs from group B, in which 8% of the animals had strongly positive reaction (++) and 24% -slightly positive (+). The correlation between the concentration of total and free fraction of the thyroxin and the level of the TgAb s were observed in group A. The tendency to positive reaction to the antibodies (++) in dogs with lower concentrations of total thyroxine and free thyroxine was observed. It was noted that the presence of the TgAb s was common in dogs with hypothyroidism. However, it could be also found in the animals with euthyreosis.

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Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism

Cited by 150 publications

References 11 publications

Breed-specific reference intervals for assessing thyroid function in seven dog breeds

Breed-specific reference intervals for assessing thyroid function in seven dog breeds

Effects of Levothyroxine Administration and Withdrawal on the Hypothalamic‐Pituitary‐Thyroid Axis in Euthyroid Dogs

Usefulness of measuring the concentration of thyroglobulin antibodies in serum of dogs for the assessment of thyroid functioning

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